公开(公告)号：US12275753B2

公开(公告)日：2025-04-15

申请号：US18964637

申请日：2024-12-01

Applicant: HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Qian Wan ,  Lingkui Meng ,  Jing Zeng ,  Yulin Tan ,  Yue Yin ,  Qin Zhang

IPC: C07H1/00 ,  C07H15/04 ,  C07H15/12 ,  C07H15/14 ,  C07H15/18 ,  C07H15/207 ,  C07H17/07 ,  C07H19/04 ,  C07H19/052 ,  C07H19/06 ,  C07H19/16 ,  C07H19/23

Abstract: A glycosylation method involving a trivalent iodine reagent, wherein a glycosyl donor (I) is activated in the presence of a trivalent iodine reagent and a transition metal catalyst, and then reacts with a acceptor (II) under acid catalysis or directly to obtain a glycosylation product (III); in the glycosyl donor (I), Gly is a glycosyl group in which one or more hydroxyl groups on the sugar ring are protected by a protecting group; X is an oxygen, sulfur, or selenium atom; R is an alkyl group or an aryl group; the acceptor (II) is a nucleophile selected from sugars, alcohols, phenols, flavonoids, carboxylic acids, phosphates, pyrimidines, purines, amides, sulfonamides, guanidines, arylamines, indoles, enol silyl ethers, thiols, or thiophenol containing one or more free hydroxyl groups.