公开(公告)号：US09128041B2

公开(公告)日：2015-09-08

申请号：US13742616

申请日：2013-01-16

Applicant: Hamamatsu Photonics K.K.

Inventor： Gen Takebe ,  Yoichi Kawada ,  Kouichiro Akiyama

IPC: G01J5/02 ,  G01N21/3577 ,  G01N21/3563 ,  G01N21/3586

Abstract: The drug evaluation device obtains, by an attenuated reflection method using a terahertz wave, an evaluation absorption spectrum for a frequency with respect to a liquid to be evaluated. When crystalline particles are suspended in a liquid, an absorption peak having a peak area corresponding to the amount of suspension appears in its absorption spectrum. Therefore, whether or not and by what ratio crystalline particles are suspended in the liquid can be determined according to whether or not the absorption peak exists and the peak area. When amorphous particles are suspended in the liquid, the baseline of its absorption spectrum lowers according to the ratio of amorphous particles suspended in the liquid. Therefore, whether or not and by what ratio amorphous particles are suspended in the liquid can be determined according to the lowering amount of the baseline.

公开(公告)号：US09157851B2

公开(公告)日：2015-10-13

申请号：US13742616

申请日：2013-01-16

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Gen Takebe ,  Yoichi Kawada ,  Kouichiro Akiyama

IPC: G01J5/02 ,  G01N21/3577 ,  G01N21/3563 ,  G01N21/3586

CPC classification number: G01N21/3577 ,  G01N21/3563 ,  G01N21/3586 ,  G01N21/552

Abstract: The drug evaluation device obtains, by an attenuated reflection method using a terahertz wave, an evaluation absorption spectrum for a frequency with respect to a liquid to be evaluated. When crystalline particles are suspended in a liquid, an absorption peak having a peak area corresponding to the amount of suspension appears in its absorption spectrum. Therefore, whether or not and by what ratio crystalline particles are suspended in the liquid can be determined according to whether or not the absorption peak exists and the peak area. When amorphous particles are suspended in the liquid, the baseline of its absorption spectrum lowers according to the ratio of amorphous particles suspended in the liquid. Therefore, whether or not and by what ratio amorphous particles are suspended in the liquid can be determined according to the lowering amount of the baseline.

Abstract translation: 药物评价装置通过使用太赫兹波的衰减反射法获得关于待评价液体的频率的评价吸收光谱。 当结晶颗粒悬浮在液体中时，具有对应于悬浮液量的峰面积的吸收峰出现在其吸收光谱中。 因此，可以根据是否存在吸收峰和峰面积来确定晶体颗粒悬浮在液体中的比例和比例。 当无定形颗粒悬浮在液体中时，其吸收光谱的基线根据悬浮在液体中的无定形颗粒的比例而降低。 因此，可以根据基线的降低量来确定无定形颗粒是否悬浮在液体中的比例。