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公开(公告)号：US20130089891A1
公开(公告)日：2013-04-11
申请号：US13689145
申请日：2012-11-29
Applicant: HITACHI, LTD.
Inventor： Hideyuki NODA , Satoshi OZAWA , Masahiro OKANOJO , Kenko UCHIDA
IPC: C12Q1/04
Abstract: An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member, and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.
Abstract translation: 一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。 该装置包括：第一遮光箱，其具有样本容器保持器和其中的快门单元，所述快门单元包括部分地由板构件的运动形成的顶板和在其中具有光电检测器的第二遮光箱。 虽然没有实现测量，但是快门单元被关闭以阻止杂散光入射到光电检测器，并且在实现测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入到 通孔形成在顶板中，使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。
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公开(公告)号：US20210317503A1
公开(公告)日：2021-10-14
申请号：US17224957
申请日：2021-04-07
Applicant: HITACHI, LTD. , University of Toyama
Inventor： Shunsuke KAWABE , Yuichi UCHIHO , Hideyuki NODA , Hideki NIIMI , Atsushi MATSUI
Abstract: Provided is a bacterium number measuring system comprising a database storing known bacterial growth patterns in advance and an analyzing part. The analyzing part has first cultures containing a bacterial liquid that contains a measurement target bacteria and second cultures being different from the first cultures and containing the bacterial liquid and an antimicrobial drug. The analyzing part performs bacterium number measurement which measures the number of bacteria in the first cultures on a culturing part where culturing has started in the first and second cultures. The analyzing part compares the bacterium number measurement result with the growth curves stored in the database and thereby determines a timing to perform MIC measurement which measures the number of bacteria in the second cultures to determine a minimum inhibitory concentration of the measurement target bacterium. The analyzing part performs the MIC measurement at the thus-determined timing.
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Patent Agency Ranking
公开(公告)号：US20180057853A1
公开(公告)日：2018-03-01
申请号：US15557017
申请日：2015-03-17
Applicant: Hitachi, Ltd.
Inventor： Hideyuki NODA , Hiroko TADA , Chihiro UEMATSU , Masahiro OKANOJO
CPC classification number: C12Q1/18 , C12M1/34 , C12M23/44 , C12M25/06 , C12M29/00 , C12M45/06 , C12M45/20 , C12Q1/66 , G01N21/763
Abstract: Provided is a antimicrobial susceptibility testing device, including: an ATP examination culture plate that includes a reaction vessel, a reagent holding parts for holding reagents to be supplied to the reaction vessel, and a culture solution holding part for holding a culture solution to be supplied to the reaction vessel, and has plural layers that can be joined and separated; a gas feeding path for feeding a gas into the ATP examination culture plate; a heater; an optical detection unit; and a determination unit for determining sensitivity of a bacterial strain contained in the culture solution to a drug based on a detection result of the optical detection unit, wherein when the plural layers of the ATP examination culture plate are joined, at least the culture solution holding part and the reaction vessel are in a sealed state while communicating with each other.
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公开(公告)号：US20170314057A1
公开(公告)日：2017-11-02
申请号：US15526388
申请日：2014-12-26
Applicant: HITACHI, LTD.
Inventor： Hiroko TADA , Hideyuki NODA , Hideki NIIMI , Isao KITAJIMA
IPC: C12Q1/18
Abstract: When bacteria growth is determined in the related art using an ATP method, the bacteria growth is determined, based on an increase or a decrease in live bacteria ATP with the lapse of a culture time. Accordingly, it is necessary to measure the live bacteria ATP multiple times while antimicrobial susceptibility culture is carried out. It takes time and labor in sample preparation for each measurement, and it is difficult to quickly obtain an antimicrobial susceptibility result. Therefore, according to the present invention, the presence or absence of antimicrobial susceptibility of bacteria is determined, based on an ATP luminescence amount derived from dead bacteria in a culture liquid.
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公开(公告)号：US20200240921A1
公开(公告)日：2020-07-30
申请号：US16740048
申请日：2020-01-10
Applicant: HITACHI, LTD.
Inventor： Shunsuke KAWABE , Yuichi UCHIHO , Hideyuki NODA
Abstract: An apparatus, system, and method for performing an efficient luminescence measurement are disclosed. The apparatus comprises a nozzle for dispensing a luminescent reagent into a well W in a microplate M, a luminescence measurement unit for measuring luminescence occurring in the well W caused by mixing of the luminescent reagent and a specimen, and a stage (moving unit) for moving the nozzle and the luminescence measurement unit together vertically and horizontally, wherein the nozzle is secured to the stage and the luminescence measurement unit is mounted to be movable vertically with respect to the stage through a holder and springs interposed between the luminescence measurement unit and the holder.
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公开(公告)号：US20180024070A1
公开(公告)日：2018-01-25
申请号：US15547910
申请日：2015-04-30
Applicant: Hitachi, Ltd.
Inventor： Masahiro OKANOJO , Hideyuki NODA
CPC classification number: G01N21/76 , C12Q1/02 , G01N21/763 , G01N35/00871 , G01N35/025 , G01N35/04 , G01N35/1004 , G01N35/1009 , G01N2035/00277 , G01N2035/00306 , G01N2035/00356 , G01N2035/0422 , G01N2035/0432 , G01N2035/0444 , G01N2201/0231 , G01N2201/064
Abstract: A luminometer apparatus includes, inside a light-shielded room, a container rack loaded with holding containers, a dispensation mechanism that dispenses a liquid, a rotary plate that turns, while holding a plurality of reaction containers which accommodate a mixture liquid of a sample and a luminescent reagent on a concentric annular plate, and is provided with a gap allowing the container rack to pass therethrough between at least a pair of adjacent ones of the reaction containers, and a photodetection unit that performs luminescence measurements. The light-shielded room has an insertion opening having a width allowing for insertion of the container rack and provided to be openable and closable. The rotary plate is provided with a region in which the container rack can be installed inside a region of passage of the reaction containers, when turning, and is provided to be turnable where the light-shielded room is in a closed state.
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公开(公告)号：US20200040374A1
公开(公告)日：2020-02-06
申请号：US16298789
申请日：2019-03-11
Applicant: HITACHI, LTD.
Inventor： Chihiro MANRI , Hideyuki NODA , Naoko SENDA
Abstract: Provided is a method for detecting a microorganism in a test sample containing cells, including a step of adding the sample to a microorganism culture medium, a step of culturing the microorganism culture medium containing the sample, a step of sampling a part of the culture medium at a predetermined time, a step of acquiring the ATP level of the sampled culture medium, and a step of detecting the microorganism in the sample based on the change of the ATP level over time.
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