公开(公告)号：US20180203029A1

公开(公告)日：2018-07-19

申请号：US15746434

申请日：2016-07-11

Applicant: Hitachi High-Technologies Corporation

Inventor： Koshin HAMASAKI ,  Yoshihiro YAMASHITA

IPC: G01N35/10 ,  F16K7/14 ,  B01L3/00

CPC classification number: G01N35/1002 ,  B01L3/52 ,  B01L3/567 ,  B01L2200/0684 ,  B01L2200/16 ,  F16K7/14 ,  G01N35/10

Abstract: An amount of gas remaining within a fluid control valve is reduced according to a method for fixing the fluid control valve to achieve highly accurate trace dispensation by simply removing gas. The dispensing device has a discharge nozzle, a liquid feeding tube that is disposed so as to connect a reagent bottle in which a reagent is stored and the discharge nozzle and forms a reagent flow path, and a fluid control valve that is disposed on the liquid feeding tube route connecting the reagent bottle and the discharge nozzle. The fluid control valve is provided with a reagent flow path having a liquid inlet and a liquid outlet and a diaphragm valve provided in the middle of the flow path. The fluid control valve is disposed in an orientation such that the diaphragm valve is disposed at the bottom of the flow path of the fluid control valve.

公开(公告)号：US20200209273A1

公开(公告)日：2020-07-02

申请号：US16646622

申请日：2018-11-29

Applicant: Hitachi High-Technologies Corporation ,  Roche Diagnostics Operations, Inc.

Inventor： Yuichiro OTA ,  Takaaki HAGIWARA ,  Yoshihiro YAMASHITA ,  Koshin HAMASAKI ,  Michaela WINDFUHR ,  Heike GUGGEMOS ,  Johannes STOECKEL ,  Guenter ZIEGLER ,  Michael KUEHNL

IPC: G01N35/10

Abstract: The object of the invention is to provide an automatic analysis apparatus capable of setting a dispensing mechanism for measuring dispensing accuracy and a dispensing volume, and capable of performing dispensing accuracy measurement without absorbance measurement. Regarding a dispensing accuracy, a dispensing mechanism to be measured is designated. Parameters including a dispensing volume and the like are input. A dispensing operation of the input dispensing volume is automatically performed for each designated dispensing mechanism. A reaction vessel contains, for example, a reagent of the input dispensing volume which has been dispensed by the designated dispensing mechanism. By measuring a weight of the reagent in the reaction vessel, or the like, it is possible to measure the dispensing accuracy of the designated dispensing mechanism.

公开(公告)号：US20160003814A1

公开(公告)日：2016-01-07

申请号：US14768771

申请日：2014-02-03

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Koshin HAMASAKI ,  Toshiro SAITO

IPC: G01N33/543 ,  G01N21/64

CPC classification number: G01N33/54333 ,  G01N21/6428 ,  G01N21/6486 ,  G01N33/54326 ,  G01N2021/6439

Abstract: Paramagnetic fine particles of 1 micron or less used under a strong magnetic field were shown to form beads-like aggregates along the magnetic flux, and become irregularly shaped as such a mass of particles combines with a flat particle layer. This phenomenon becomes a factor that degrades the quality of quantification in bioanalysis. By confining a solution of microscopic magnetic fine particles between flat substrates of high wettability as thin a vertical thickness as possible and attracting the magnetic fine particles under a magnetic field applied from the side of one of the flat substrates, the magnetic fine particles can be evenly immobilized in the form of a film on the substrate surface in a dispersion state, and the quality of the biomolecule quantification can be improved.

Abstract translation: 在强磁场下使用的1微米或更小的顺磁性细颗粒显示出沿着磁通量形成珠状聚集体，并且随着颗粒的质量与平坦颗粒层结合而变得不规则形状。 这种现象成为降低生物分析中定量质量的因素。 通过将微细磁性微粒的溶液限制在具有高润湿性的平坦基底之间尽可能薄的垂直厚度，并且在从一个平坦基底的侧面施加的磁场下吸引磁性细颗粒，磁性细颗粒可以是均匀的 以分散状态在基板表面上以膜的形式固定，并且可以提高生物分子定量的质量。