公开(公告)号：US20180272011A1

公开(公告)日：2018-09-27

申请号：US15995111

申请日：2018-05-31

Applicant: Huazhong University of Science and Technology

Inventor： Qibing ZHOU ,  Yushuang WEI ,  Xiangliang YANG

IPC: A61K49/18 ,  A61K49/12

CPC classification number: A61K49/1872 ,  A61K49/12 ,  A61K49/1863 ,  B82Y5/00 ,  B82Y15/00

Abstract: An MRI contrast agent, including superparamagnetic nanoparticles and hydroxyethyl starch. The weight ratio of the superparamagnetic nanoparticles to the hydroxyethyl starch is between 1:5 and 1:15. The superparamagnetic nanoparticles have a particle size of 100-140 nm, and include the following layers, from the inside out, ferrous ferric oxide particles, citric acid, and poly-R-lysine. The citric acid accounts for 6-13 wt. % of the ferrous ferric oxide particles. The poly-R-lysine accounts for 6-20 wt. % of the ferrous ferric oxide particles.