公开(公告)号：US20210371855A1

公开(公告)日：2021-12-02

申请号：US17252430

申请日：2019-06-17

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Lisa BELMONT ,  Jeff HAGER ,  Yujiro HATA ,  Lorn KATEGAYA

IPC: C12N15/11 ,  A61P35/00 ,  A61K31/4015 ,  A61K47/68 ,  C12N15/113 ,  C12N9/22 ,  A61K38/46 ,  A61K31/7088 ,  C12N15/86 ,  C12N9/10 ,  A61K38/45 ,  C12Q1/533 ,  A61K45/06

Abstract: The present invention provides methods of negatively modulating the Werner protein (WRN) to inhibit proliferative cells characterized by high microsatellite instability (MSI-H), for example to treat proliferative diseases (such as cancer) characterized by high MSI (MSI-H). Further provided are compositions used in such methods.