公开(公告)号：US11945838B2

公开(公告)日：2024-04-02

申请号：US16723280

申请日：2019-12-20

Applicant: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH

Inventor： Sandanaraj Selvaraj Britto ,  Mullapudi Mohan Reddy

IPC: A61K47/54 ,  A61K38/17 ,  A61K38/38 ,  A61K38/47 ,  A61K38/48 ,  A61K47/60 ,  C07D401/14 ,  C07D403/12 ,  C07K1/18

CPC classification number: C07K1/18 ,  A61K38/1767 ,  A61K38/385 ,  A61K38/47 ,  A61K38/4826 ,  A61K47/545 ,  A61K47/60 ,  C07D401/14 ,  C07D403/12

Abstract: The present invention discloses a novel cost effective method for synthesis of protein/peptide amphiphiles irrespective of functional and structural classification of proteins useful in designing a vaccine candidate from antigenic protein. The protein modification of the present invention is universal and hence any protein/peptide can be converted into amphiphilic proteins/peptides.

公开(公告)号：US10188136B2

公开(公告)日：2019-01-29

申请号：US15435055

申请日：2017-02-16

Applicant: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH

Inventor： Sandanaraj Selvaraj Britto ,  Mullapudi Mohan Reddy ,  Pavankumar Janardhan Bhandari ,  Kasuladevu Jagannadha Rao

IPC: A61K8/66 ,  A23L33/17 ,  A61K9/48 ,  C07K1/14 ,  C12N9/50 ,  A61K8/55 ,  A61Q19/00 ,  B82Y5/00

Abstract: The present invention discloses hydrophobin mimics of formula (I) comprising a protein head group, hydrophilic linker and hydrophobic tail and to a process for synthesis of library of hydrophobin mimics thereof. The hydrophobin mimics of the present invention self-assemble to form protein nanoparticles/nanocontainer either alone or in a specified chemical environment. The hydrophobin mimics (I) of the present invention find application in area of bio-nanotechnology.

公开(公告)号：US11807884B2

公开(公告)日：2023-11-07

申请号：US16771124

申请日：2018-12-08

Applicant: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH

Inventor： Sandanaraj Selvaraj Britto ,  Pavankumar Janardhan Bhandari ,  Mullapudi Mohan Reddy

IPC: C12N9/96 ,  A61K47/60 ,  C08G83/00 ,  C12N9/64 ,  C12N9/76 ,  A61K47/59 ,  B82Y5/00

CPC classification number: C12N9/96 ,  A61K47/59 ,  A61K47/60 ,  C08G83/008 ,  C12N9/6424 ,  C12N9/6427 ,  C12Y304/21001 ,  C12Y304/21004 ,  C12Y304/21062 ,  C12Y304/21064 ,  B82Y5/00

Abstract: The present invention discloses monodisperse protein-dendron conjugates that self-assemble to generation-dependent supramolecular protein assemblies of different size and surface charges. The invention further provides a process for synthesis of protein-dendron conjugates containing hydrophobic dendron of different generations.

公开(公告)号：US11173212B2

公开(公告)日：2021-11-16

申请号：US16146891

申请日：2018-09-28

Applicant: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH

Inventor： Sandanaraj Selvaraj Britto ,  Pavankumar Janardhan Bhandari ,  Mullapudi Mohan Reddy

IPC: A61K47/64 ,  A61K38/48 ,  A61K47/54 ,  C12N9/96 ,  A61K41/00 ,  A61K38/00

Abstract: The present invention discloses stimuli-sensitive protein conjugate which can make supramolecular protein assemblies and methods for using the same. The present invention provides simple and rational process for construction of said stimuli-sensitive spherical protein assemblies through supramolecular chemical strategy.