公开(公告)号：US20210262041A1

公开(公告)日：2021-08-26

申请号：US17266206

申请日：2019-08-08

Applicant: INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH

Inventor： Sanjeev GALANDE ,  Rutika NAIK

IPC: C12Q1/6886

Abstract: The present invention provides an in-vitro process for profiling a combined expression pattern of SATB (special AT-rich sequence-binding protein-1) family chromatin organizers i.e. SATB-1 and SATB-2 as a biomarker tool for cancer prognosis to assess cancer aggressiveness and it progression in an array of cancer types. The combined expression pattern of SATB is established by the method of Kaplan Meier survival analysis of a dataset of patients from a plurality of cancer types. Further, the present invention provides a prognostic kit to evaluate the progression of cancer by using the combined expression pattern of SATB-1 and SATB-2 as a biomarker tool for cancer prognosis.