公开(公告)号：US20140011266A1

公开(公告)日：2014-01-09

申请号：US13639584

申请日：2011-04-06

Applicant: IT-IS INTERNATIONAL LIMITED

Inventor： Benjamin Masterman Webster ,  James Richard Howell

IPC: B01L7/00

CPC classification number: B01L7/52 ,  B01L3/50851 ,  B01L3/50853 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1894 ,  G01N21/0332 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A chemical and/or biochemical system (1) having at least one reaction vessel (3) in which chemical and/or biochemical reactions may take place, the temperature of the reaction vessels being cycled between at least a highest predetermined temperature and a lowest predetermined temperature, the system comprising a thermal mount (4) for receiving the reaction vessel (s), the thermal mount being thermally coupled to a first, thermally conductive side of a thermoelectric module (5), a second thermally conductive side of the thermoelectric module being thermally coupled to a heat sink (6) and being provided with a pair of electrical contacts (33) to which a pair of electrically conductive wires (34) is connected for coupling to a power source, characterized in that a flexible adhesive (31, 32) is provided between the first thermally conductive side of the thermoelectric module and the thermal mount and between the second thermally conductive side of the thermoelectric module and the heat sink, whereby the adhesive is relatively thermally insulating compared to the first and second thermally conductive sides of the thermoelectric module and forms the sole coupling, thermal or mechanical, between the thermoelectric module and the thermal mount and between the thermoelectric module and the heat sink.

Abstract translation: 化学和/或生化系统（1）具有至少一个其中可能发生化学和/或生物化学反应的反应容器（3），反应容器的温度在至少最高预定温度和最低预定温度之间循环 所述系统包括用于接收所述反应容器的热安装座（4），所述热安装件热耦合到热电模块（5）的第一导热侧，所述热电模块的第二导热侧 被热耦合到散热器（6）并且设置有一对电触点（33），一对导电线（34）连接到所述一对电触头（34）以耦合到电源，其特征在于，柔性粘合剂（31） ，32）设置在热电模块的第一导热侧和热座之间以及热电模块的第二导热侧之间，并且热sin k，由此与热电模块的第一和第二导热侧相比，粘合剂相对热绝缘，并且在热电模块和热安装座之间以及热电模块和散热器之间形成热耦合或机械的单独耦合。

公开(公告)号：US20210162419A1

公开(公告)日：2021-06-03

申请号：US17176019

申请日：2021-02-15

Applicant: IT-IS INTERNATIONAL LIMITED

Inventor： James Richard Howell ,  Benjamin Masterman Webster

IPC: B01L7/00 ,  G01N21/03 ,  B01L9/06 ,  G01N21/27

Abstract: A chemical and/or biochemical apparatus (10) includes a thermal mount (14) having wells (26) for receiving reaction vessels (12), a thermal module (16) having a first side thermally coupled to the thermal mount (14), a first heat sink (18) thermally coupled to a second side of the thermal module, the heat sink (18) having a body and thermally conductive fins (32) extending outwards from the body of the first heat sink (18), and a printed circuit board (54) having electronic components for controlling at least the thermal module (16), an excitation light source (62), and a light sensor (52). A first set of light waveguides (60) delivers excitation light to a reaction vessel, and a second set of light waveguides (38) receives light from a reaction vessel and delivers the light to the light sensor (52). The printed circuit board (54), the excitation light source (62), the light sensor (52) and the light waveguides (38, 60) are arranged within an interior space (5) of the first heat sink (18).

公开(公告)号：US12064772B2

公开(公告)日：2024-08-20

申请号：US17176019

申请日：2021-02-15

Applicant: IT-IS INTERNATIONAL LIMITED

Inventor： James Richard Howell ,  Benjamin Masterman Webster

IPC: B01L7/00 ,  B01L9/06 ,  G01N21/03 ,  G01N21/27

CPC classification number: B01L7/52 ,  B01L9/06 ,  G01N21/0332 ,  G01N21/272 ,  B01L2300/02 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2300/087 ,  B01L2300/123 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1827 ,  G01N2201/0231 ,  G01N2201/0846

Abstract: A chemical and/or biochemical apparatus (10) includes a thermal mount (14) having wells (26) for receiving reaction vessels (12), a thermal module (16) having a first side thermally coupled to the thermal mount (14), a first heat sink (18) thermally coupled to a second side of the thermal module, the heat sink (18) having a body and thermally conductive fins (32) extending outwards from the body of the first heat sink (18), and a printed circuit board (54) having electronic components for controlling at least the thermal module (16), an excitation light source (62), and a light sensor (52). A first set of light waveguides (60) delivers excitation light to a reaction vessel, and a second set of light waveguides (38) receives light from a reaction vessel and delivers the light to the light sensor (52). The printed circuit board (54), the excitation light source (62), the light sensor (52) and the light waveguides (38, 60) are arranged within an interior space (5) of the first heat sink (18).

公开(公告)号：US09089828B2

公开(公告)日：2015-07-28

申请号：US14019687

申请日：2013-09-06

Applicant: IT-IS International Limited

Inventor： James Richard Howell ,  Benjamin Masterman Webster ,  Mark Quentin Clark ,  Richard Alfred Howell

IPC: B01J19/00 ,  G01N21/25 ,  G01N21/64

CPC classification number: B01J19/0046 ,  G01N21/253 ,  G01N21/6452 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An apparatus for detecting light emanating from chemical or biochemical reactions occurring in at least one reaction vessel of a plurality of reaction vessels is disclosed. Each reaction vessel has a receptacle portion having an emitting area from which light can emanate. A plurality of light waveguides are arranged to guide light from apertures in a masking element to a light dispersing device for dispersing the light from each waveguide into a dispersed spectrum. A light detecting device detects specific spectra in the dispersed spectra of light substantially simultaneously In one embodiment, the light waveguides have a diameter that tapers from a first end substantially similar in diameter to the area of the top of the reaction vessel to a second end that is substantially smaller in diameter.

Abstract translation: 公开了一种用于检测在多个反应容器的至少一个反应容器中发生的化学或生物化学反应产生的光的装置。 每个反应容器具有容纳部分，该容器部分具有能够发出光的发射区域。 多个光波导被布置成将来自掩模元件中的孔的光引导到用于将来自每个波导的光分散到分散光谱中的光分散装置。 光检测装置基本上同时检测光的分散光谱中的特定光谱。在一个实施例中，光波导具有从直径基本上类似于第一端的直径与反应容器顶部的面积逐渐变细的直径， 其直径显着更小。

公开(公告)号：US20140005078A1

公开(公告)日：2014-01-02

申请号：US14019687

申请日：2013-09-06

Applicant: IT-IS International Limited

Inventor： James Richard Howell ,  Benjamin Masterman Webster ,  Mark Quentin Clark ,  Richard Alfred Howell

IPC: B01J19/00

CPC classification number: B01J19/0046 ,  G01N21/253 ,  G01N21/6452 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: An apparatus for detecting light emanating from chemical or biochemical reactions occurring in at least one reaction vessel of a plurality of reaction vessels is disclosed. Each reaction vessel has a receptacle portion having an emitting area from which light can emanate. A plurality of light waveguides are arranged to guide light from apertures in a masking element to a light dispersing device for dispersing the light from each waveguide into a dispersed spectrum. A light detecting device detects specific spectra in the dispersed spectra of light substantially simultaneously In one embodiment, the light waveguides have a diameter that tapers from a first end substantially similar in diameter to the area of the top of the reaction vessel to a second end that is substantially smaller in diameter.

Abstract translation: 公开了一种用于检测在多个反应容器的至少一个反应容器中发生的化学或生物化学反应产生的光的装置。 每个反应容器具有容纳部分，该容器部分具有能够发出光的发射区域。 多个光波导被布置成将来自掩模元件中的孔的光引导到用于将来自每个波导的光分散到分散光谱中的光分散装置。 光检测装置基本上同时检测光的分散光谱中的特定光谱。在一个实施例中，光波导具有从直径基本上类似于第一端的直径与反应容器顶部的面积逐渐变细的直径， 其直径显着更小。