公开(公告)号：US20190300496A1

公开(公告)日：2019-10-03

申请号：US16315576

申请日：2017-07-14

Applicant: ITALFARMACO SPA

Inventor： Andrea STEVENAZZI ,  Giovanni SANDRONE ,  Daniela MODENA ,  Samuele Pietro POZZI ,  Barbara VERGANI ,  Maria LATTANZIO ,  Paolo MASCAGNI ,  Christian STEINKÜHLER ,  Gianluca FOSSATI

IPC: C07D317/60 ,  C07C259/10 ,  C07D221/04 ,  C07D233/64 ,  C07D213/56 ,  C07D405/12 ,  C07D417/12 ,  C07D409/12 ,  A61P35/00

Abstract: The present invention relates to new benzo-N-hydroxy amide compounds of formula (I) and pharmaceutically acceptable salts, isomers and prodrugs thereof, which show a significant inhibitory activity on the proliferation of tumor cells and specifically of cancer stem cells.