公开(公告)号：US10590101B2

公开(公告)日：2020-03-17

申请号：US16315576

申请日：2017-07-14

Applicant: ITALFARMACO SPA

Inventor： Andrea Stevenazzi ,  Giovanni Sandrone ,  Daniela Modena ,  Samuele Pietro Pozzi ,  Barbara Vergani ,  Maria Lattanzio ,  Paolo Mascagni ,  Christian Steinkühler ,  Gianluca Fossati

IPC: C07D317/60 ,  C07D215/14 ,  C07D407/12 ,  C07D213/643 ,  C07D209/18 ,  A61P35/00 ,  C07C259/10 ,  C07D213/56 ,  C07D221/04 ,  C07D233/64 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  A61K31/165 ,  A61K31/357 ,  A61K31/4035 ,  A61K31/443 ,  A61K31/47 ,  C07D317/06

Abstract: The present invention relates to new benzo-N-hydroxy amide compounds of formula (I) and pharmaceutically acceptable salts, isomers and prodrugs thereof, which show a significant inhibitory activity on the proliferation of tumor cells and specifically of cancer stem cells.