公开(公告)号：US20240207228A1

公开(公告)日：2024-06-27

申请号：US18555103

申请日：2022-04-19

Applicant: ITALFARMACO SPA

Inventor： Gianluca FOSSATI ,  Flavio LEONI ,  Pietro Samuele POZZI ,  Elisabetta GALBIATI ,  Christian STEINKÜHLER

IPC: A61K31/41 ,  A61K39/00 ,  A61K39/395 ,  A61P35/00

CPC classification number: A61K31/41 ,  A61K39/3955 ,  A61P35/00 ,  A61K2039/545

Abstract: The present invention relates to a combination comprising N-hydroxy-4-((5-(thiophen-2-yl)-1H-tetrazol-1-yl)methyl)benzamide or a pharmaceutically acceptable salt thereof and at least one CTLA4 checkpoint inhibitor, useful in the immunotherapy of tumors and in the treatment of one or more HDAC6-mediated diseases.