公开(公告)号：US20180311160A1

公开(公告)日：2018-11-01

申请号：US15770443

申请日：2016-10-28

Applicant: ITALFARMACO SPA

Inventor： Giuseppe COLOMBO ,  Roberta ARTICO ,  Paolo MASCAGNI ,  Maria Valmen MONZANI ,  Silvia PUCCIANTI

IPC: A61K9/10 ,  A61K9/00 ,  A61K47/26 ,  A61K47/10 ,  A61K47/36 ,  A61K47/12 ,  A61K47/02 ,  A61K31/325 ,  A61P21/00 ,  A61P19/02 ,  A61P35/02 ,  A61P7/02

Abstract: Physically and chemically stable oral liquid formulations of Givinostat (Diethyl-[6-(4-hydroxycarbamoyl-phenylcarbamoyloxymethyl)-naphthalen-2-yl-methyl]-ammonium chloride) are disclosed, together with methods for the preparation thereof. Such oral formulations are in the form of aqueous suspensions and contain Givinostat and/or pharmaceutically acceptable salts and/or derivatives thereof, at least a wetting agent and/or at least a density-imparting agent. Such formulations are suitable for oral administration for systemic therapeutic action.