公开(公告)号：US10188671B2

公开(公告)日：2019-01-29

申请号：US15555721

申请日：2016-03-04

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Motomu Kanai ,  Yohei Soma ,  Yusuke Shimizu ,  Atsuhiko Taniguchi ,  Kounosuke Oisaki ,  Yoichiro Kuninobu

IPC: A61K31/69 ,  C07F5/02 ,  A61P25/28 ,  A61P3/10 ,  A61P25/16 ,  C07D401/14 ,  C07D455/04 ,  C07D207/44 ,  C07D207/456 ,  A61K31/4025 ,  A61K31/4725 ,  C07D207/46 ,  C07D215/06 ,  A61K41/00

Abstract: Provided is a compound which is useful as an in vivo applicable, amyloid-oxygenating catalyst selective for amyloid and applicable not only to an Aβ peptide, but also to other amyloids and a drug containing the compound for preventing and/or treating amyloid-related diseases. Disclosed is a boron-dipyrrin complex represented by the following formula (1)

公开(公告)号：US09932333B2

公开(公告)日：2018-04-03

申请号：US15326320

申请日：2015-07-15

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Motomu Kanai ,  Yohei Soma ,  Atsuhiko Taniguchi ,  Yusuke Shimizu

IPC: C07D455/04 ,  C07D417/04

CPC classification number: C07D455/04 ,  A61K31/4725 ,  A61K31/4745 ,  A61K38/00 ,  C07D417/04 ,  C07K7/06 ,  C07K14/47

Abstract: It is intended to provide: a compound useful as an amyloid oxidation catalyst which is applicable in vivo and is applicable not only to Aβ peptides but to other amyloids; and a prophylactic or therapeutic drug for an amyloid-related disease, comprising the same. The present invention provides a benzothiazole compound represented by the following formula (1) wherein X represents a halogen atom; R1 represents an optionally substituted hydrocarbon group; R2 represents a hydrogen atom or an optionally substituted hydrocarbon group; R3 and R4 are the same or different and each represent a hydrogen atom, an optionally substituted hydrocarbon group, an alkoxy group, a halogen atom, an amino group, a nitro group, or a cyano group; R2 and R4 optionally together form an alkylene group; and R5 represents an anion.