公开(公告)号：US20050175707A1

公开(公告)日：2005-08-11

申请号：US10512345

申请日：2003-04-23

Applicant: James Talton ,  Christopher McConville

Inventor： James Talton ,  Christopher McConville

IPC: A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  A61K9/51 ,  B01J2/18 ,  B01J13/04

CPC classification number: A61K9/0075 ,  A61K9/0043 ,  A61K9/14 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1688 ,  A61K9/1694 ,  A61K9/5138 ,  A61K9/5146 ,  A61K9/5153 ,  A61K9/5192 ,  B01J2/18 ,  B01J13/04

Abstract: The present invention relates to processes for forming particles including drugs in a solution, changing the bulk or surface properties of a drug particle, and/or microencapsulation drug particles, and compositions produced thereby. In some embodiments, the process described utilized mechanical agitation, more specifically low-frequency sonication, under controlled conditions, which provides mild shear forces during forming and/or precipitation to control the particle growth and mixing properties. Particle size can range from less than about 200 nanometers to greater than about one millimeter, depending on the processing conditions and application. The process described can be used to form a drug particle suspension, dry a wet powder slurry or suspension, as well as to improve the surface properties of the particle through conditioning the structure of the particle or particle surface and/or annealing the particle or particle surface. Annealing or conditioning drug particles may be used to force an amorphous to crystalline transition, creating a more stable powder, or smooth a particle surface. In addition, the process can be used to microencapsulate particles by suspending the microparticles in a non-solvent including a coating material (such as a biodegradable polymer) under controlled process conditions. The powder compositions produced thereby possess improved properties including, but not limited to, improved flow and dispersibility, controlled bioadhesion, stability, resistance to moisture, dissolution/release profiles, and/or bioavailabilities. This process, and the compositions produced, provide significant advantages in the manufacture of pharmaceutical particulate formulations, as well as biomedical, diagnostic, and chromatography particulate compositions, where sensitive macromolecules, such as proteins or DNA, are involved that would be degraded using more rigorous processing conditions or temperatures.

公开(公告)号：US20070062255A1

公开(公告)日：2007-03-22

申请号：US11557797

申请日：2006-11-08

Applicant: James Talton

Inventor： James Talton

IPC: G01N33/497 ,  G01N1/22

CPC classification number: A61B5/097 ,  A61B5/0059 ,  A61B5/083 ,  G01N1/2214 ,  G01N29/022 ,  G01N33/497 ,  G01N2001/2244 ,  G01N2030/085 ,  G01N2030/128 ,  G01N2291/0215 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426

Abstract: The present invention provides methods of collecting and detecting compounds in a human breath sample, comprising: exhaling into a handheld sample collector to absorb at least one breath compound in an exhaled breath collector of said collector; connecting the handheld sample collector to a breath analyzer; transferring the breath compounds from the exhaled breath collector of the sample collector into the breath analyzer; and detecting breath compounds using two or more sensors. The method may be performed to detect breath compounds for determining health or disease diagnosis, or for drug monitoring.

Abstract translation: 本发明提供了收集和检测人类呼吸样品中化合物的方法，包括：将呼吸进入手持式样品收集器以吸收所述收集器的呼出呼吸收集器中的至少一种呼吸化合物; 将手持式样品收集器连接到呼吸分析仪; 将呼吸化合物从样品收集器的呼出气体收集器转移到呼吸分析器中; 并使用两个或更多个传感器检测呼吸化合物。 可以执行该方法以检测用于确定健康或疾病诊断或用于药物监测的呼吸化合物。

公开(公告)号：US20080008766A1

公开(公告)日：2008-01-10

申请号：US11776997

申请日：2007-07-12

Applicant: James Talton ,  James Kirk

Inventor： James Talton ,  James Kirk

IPC: A61K35/32 ,  A61K9/14 ,  A61K9/16 ,  A61P9/00

CPC classification number: A61K9/0024 ,  A61K9/5078 ,  A61K35/32 ,  A61L24/001 ,  A61L24/0047 ,  A61L24/02 ,  A61L27/222 ,  A61L27/34 ,  A61L27/3608 ,  A61L27/365 ,  A61L2430/02 ,  C08L89/06

Abstract: This invention relates to an improved method of preparing an implantable gel or paste for placement between injured bones or placement in bony voids to induce regeneration, and the compositions produced thereby. Specifically, mineral, ceramic, or processed bone particles are coated with a high molecular weight polymer capable of forming a viscous gel when reconstituted with water, saline, autologous blood, sera, or other medically acceptable solution. This high molecular weight polymer coating material may be a natural or synthetic polymeric material, producing a wettable gel upon exposure to water, saline, or another solution. In storage, the composition will be granular and dry but easily wetted. In use, the material is reconstituted to a viscous malleable paste by the simple addition of water or other medically acceptable solution without the need for aggressive mixing. The paste may be delivered by syringe or manually deposited yet will be resistant to lavage or to displacement by gravity induced flow.

Abstract translation: 本发明涉及一种制备可植入凝胶或糊剂的改进方法，用于放置在受损骨骼之间或放置在骨空洞中以诱导再生，以及由此产生的组合物。 具体地，当用水，盐水，自体血液，血清或其他医学上可接受的溶液重构时，矿物，陶瓷或加工的骨颗粒被涂覆有能够形成粘性凝胶的高分子量聚合物。 该高分子量聚合物涂层材料可以是天然或合成的聚合材料，在暴露于水，盐水或另一溶液时产生可湿性凝胶。 在储存中，组合物将颗粒状并干燥，但容易润湿。 在使用中，通过简单添加水或其他医学上可接受的溶液将材料重构成粘稠的可延展的糊剂，而不需要积极的混合。 糊剂可以通过注射器递送或手动沉积，但是可以通过重力诱导的流动来抵抗灌洗或移位。

公开(公告)号：US20060051522A1

公开(公告)日：2006-03-09

申请号：US10502022

申请日：2003-01-22

Applicant: James Talton

Inventor： James Talton

IPC: B05D3/00 ,  C23C14/30 ,  C23C16/00

CPC classification number: C23C14/28 ,  A61L27/28 ,  A61L2400/18 ,  B05D1/00 ,  B05D1/60 ,  C23C14/06 ,  C23C14/12 ,  C23C14/228

Abstract: A method comprising providing a target material (115), providing a substrate (107), ablating the target material (115) to form ablated target particulate material (117), directing the ablated particulate material (117) toward the substrate (107) with a gas flow, and coating the substrate surface (107).

Abstract translation: 一种方法，包括提供目标材料（115），提供衬底（107），烧蚀所述靶材料（115）以形成烧蚀的靶材料材料（117），将所述消融的颗粒材料（117）引导到所述衬底（107） 气流，并且涂覆基板表面（107）。

公开(公告)号：US20080014279A1

公开(公告)日：2008-01-17

申请号：US11777001

申请日：2007-07-12

Applicant: James Talton ,  James Kirk

Inventor： James Talton ,  James Kirk

IPC: A61K35/32 ,  A61K9/14 ,  A61P19/00

CPC classification number: A61K9/0024 ,  A61K9/5078 ,  A61K35/32 ,  A61L24/001 ,  A61L24/0047 ,  A61L24/02 ,  A61L27/222 ,  A61L27/34 ,  A61L27/3608 ,  A61L27/365 ,  A61L2430/02 ,  C08L89/06

Abstract: This invention relates to an improved method of preparing an implantable gel or paste for placement between injured bones or placement in bony voids to induce regeneration, and the compositions produced thereby. Specifically, mineral, ceramic, or processed bone particles are coated with a high molecular weight polymer capable of forming a viscous gel when reconstituted with water, saline, autologous blood, sera, or other medically acceptable solution. This high molecular weight polymer coating material may be a natural or synthetic polymeric material, producing a wettable gel upon exposure to water, saline, or another solution. In storage, the composition will be granular and dry but easily wetted. In use, the material is reconstituted to a viscous malleable paste by the simple addition of water or other medically acceptable solution without the need for aggressive mixing. The paste may be delivered by syringe or manually deposited yet will be resistant to lavage or to displacement by gravity induced flow.

Abstract translation: 本发明涉及一种制备可植入凝胶或糊剂的改进方法，用于放置在受损骨骼之间或放置在骨空洞中以诱导再生，以及由此产生的组合物。 具体地，当用水，盐水，自体血液，血清或其他医学上可接受的溶液重构时，矿物，陶瓷或加工的骨颗粒被涂覆有能够形成粘性凝胶的高分子量聚合物。 该高分子量聚合物涂层材料可以是天然或合成的聚合材料，在暴露于水，盐水或另一溶液时产生可湿性凝胶。 在储存中，组合物将颗粒状并干燥，但容易润湿。 在使用中，通过简单添加水或其他医学上可接受的溶液将材料重构成粘稠的可延展的糊剂，而不需要积极的混合。 糊剂可以通过注射器递送或手动沉积，但是可以通过重力诱导的流动来抵抗灌洗或移位。

公开(公告)号：US20060189958A1

公开(公告)日：2006-08-24

申请号：US11358348

申请日：2006-02-21

Applicant: James Talton ,  James Kirk

Inventor： James Talton ,  James Kirk

IPC: A61B19/00

CPC classification number: A61M5/1782 ,  A61J1/201 ,  A61J1/2089 ,  A61M5/284

Abstract: The present disclosure relates to a device (such as, e.g., a syringe) for reconstituting a material to be reconstituted, comprising (a) a first structure having at least one first inner portion configured to receive at least a portion of a material to be reconstituted, comprising a first proximal opening and a first distal opening, wherein the first distal opening has a first mating structure, and a first movable member selectively inserted into said first inner portion to urge out the material to be reconstituted, (b) a second structure having at least one second inner portion configured to receive at least a portion of a reconstituting material, comprising a second proximal opening and a second distal opening, wherein the second distal opening has a second mating structure, and a second movable member selectively inserted into said second inner portion to urge out the reconstituting material, and (c) a connector device, comprising a first mating portion configured to mate with the first mating structure, a second mating portion configured to mate with the second mating structure, and a lumen extending between the first and second mating portions and configured to permit communication between the materials in said first and second structures. The disclosure further relates to methods for reconstituting a material to be reconstituted.

Abstract translation: 本发明涉及一种用于重建待重建材料的装置（例如，注射器），包括（a）第一结构，其具有至少一个第一内部部分，该第一内部部分构造成容纳至少一部分材料 其包括第一近端开口和第一远端开口，其中所述第一远端开口具有第一配合结构，以及第一可移动构件，其选择性地插入所述第一内部部分中以推出待重建的材料，（b） 结构，其具有至少一个第二内部部分，其被构造成容纳至少一部分重构材料，包括第二近端开口和第二远端开口，其中所述第二远端开口具有第二配合结构，以及第二可移动构件， 所述第二内部部分用于推出所述重构材料，以及（c）连接器装置，包括配置成与所述第一配合部分配合的第一配合部分 第一配合结构，配置成与第二配合结构配合的第二配合部分，以及在第一和第二配合部分之间延伸并且被配置为允许所述第一和第二结构中的材料之间的连通的管腔。 本公开还涉及用于重建待重构的材料的方法。

公开(公告)号：US20060051427A1

公开(公告)日：2006-03-09

申请号：US11070413

申请日：2005-03-02

Applicant: James Talton ,  James Kirk

Inventor： James Talton ,  James Kirk

IPC: A61K35/32

CPC classification number: A61K9/0024 ,  A61K9/5078 ,  A61K35/32 ,  A61L24/001 ,  A61L24/0047 ,  A61L24/02 ,  A61L27/222 ,  A61L27/34 ,  A61L27/3608 ,  A61L27/365 ,  A61L2430/02 ,  C08L89/06

Abstract: This invention relates to an improved method of preparing an implantable gel or paste for placement between injured bones or placement in bony voids to induce regeneration, and the compositions produced thereby. Specifically, mineral, ceramic, or processed bone particles are coated with a high molecular weight polymer capable of forming a viscous gel when reconstituted with water, saline, autologous blood, sera, or other medically acceptable solution. This high molecular weight polymer coating material may be a natural or synthetic polymeric material, producing a wettable gel upon exposure to water, saline, or another solution. In storage, the composition will be granular and dry but easily wetted. In use, the material is reconstituted to a viscous malleable paste by the simple addition of water or other medically acceptable solution without the need for aggressive mixing. The paste may be delivered by syringe or manually deposited yet will be resistant to lavage or to displacement by gravity induced flow.

Abstract translation: 本发明涉及一种制备可植入凝胶或糊剂的改进方法，用于放置在受损骨骼之间或放置在骨空洞中以诱导再生，以及由此产生的组合物。 具体地，当用水，盐水，自体血液，血清或其他医学上可接受的溶液重构时，矿物，陶瓷或加工的骨颗粒被涂覆有能够形成粘性凝胶的高分子量聚合物。 该高分子量聚合物涂层材料可以是天然或合成的聚合材料，在暴露于水，盐水或另一溶液时产生可湿性凝胶。 在储存中，组合物将颗粒状并干燥，但容易润湿。 在使用中，通过简单添加水或其他医学上可接受的溶液将材料重构成粘稠的可延展的糊剂，而不需要积极的混合。 糊剂可以通过注射器递送或手动沉积，但是可以通过重力诱导的流动来抵抗灌洗或移位。

公开(公告)号：US20050065446A1

公开(公告)日：2005-03-24

申请号：US10502950

申请日：2003-01-29

Applicant: James Talton

Inventor： James Talton

IPC: A61B5/097 ,  G01N1/22 ,  G01N33/497 ,  A61B5/08 ,  B65D81/00

CPC classification number: A61B5/097 ,  A61B5/0059 ,  A61B5/083 ,  G01N1/2214 ,  G01N29/022 ,  G01N33/497 ,  G01N2001/2244 ,  G01N2030/085 ,  G01N2030/128 ,  G01N2291/0215 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426

Abstract: The present invention provides methods of collecting and detecting compounds in a human breath sample, comprising : exhaling into a handheld sample collector to absorb at least one breath compound in an exhaled breath collector of said collector; connecting the handheld sample collector to a breath analyzer; transferring the breath compounds from the exhaled breath collector of the sample collector into the breath analyzer; and detecting breath compounds using two or more sensors. The method may be performed to detect breath compounds for determining health or disease diagnosis, or for drug monitoring.

Abstract translation: 本发明提供了收集和检测人类呼吸样品中化合物的方法，包括：将呼吸进入手持式样品收集器以吸收所述收集器的呼出呼吸收集器中的至少一种呼吸化合物; 将手持式样品收集器连接到呼吸分析仪; 将呼吸化合物从样品收集器的呼出气体收集器转移到呼吸分析器中; 并使用两个或更多个传感器检测呼吸化合物。 可以执行该方法以检测用于确定健康或疾病诊断或用于药物监测的呼吸化合物。