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    A method of preparing pH/reduction responsive polyamino acid zwitterionic nanoparticles
    2.
    发明申请
    A method of preparing pH/reduction responsive polyamino acid zwitterionic nanoparticles 审中-公开

    公开(公告)号：US20200281865A1

    公开(公告)日：2020-09-10

    申请号：US16494993

    申请日：2018-12-03

    Applicant: JIANGNAN UNIVERSITY

    Inventor： Liping ZHANG ,  Caihua NI ,  Ren LIU ,  Dawei WANG ,  Gang SHI ,  Xinxin SANG ,  Xiaofeng XIA

    IPC: A61K9/51 ,  A61K31/337 ,  A61K31/351

    Abstract: The invention discloses a preparation method of pH/reduction responsive polyamino acid zwitterionic nanoparticles, which belongs to the technical field of polymer synthesis and biomedical materials. In the invention aliphatic amines are used to initiate ring-opening polymerization of γ-benzyl-L-glutamate-N-carboxylic anhydride, and the obtained poly(γ-benzyl-L-glutamate) reacts with L-lysine to form azwitterionic polymer. The zwitterionic polymer is crosslinked by cysteamine, producing pH/reduction responsive polyamino acid zwitterionic nanoparticles after purification. The nanoparticles are pH responsive and resistant to non-specific protein adsorption. Because cysteamine contains disulfide bonds, the nanoparticles have sensitive reductive responsiveness and can load anticancer drugs for controlled release at the target site of cancer.

    Preparation Method for Charge Reversaland Reversibly Crosslinked Redox-Sensitive Nanomicelles
    3.
    发明申请
    Preparation Method for Charge Reversaland Reversibly Crosslinked Redox-Sensitive Nanomicelles 审中-公开

    公开(公告)号：US20190091147A1

    公开(公告)日：2019-03-28

    申请号：US15751577

    申请日：2017-04-27

    Applicant: Jiangnan University

    Inventor： Liping ZHANG ,  Ren LIU ,  Caihua NI ,  Yuanyuan Ding ,  Gang SHI ,  Xinxin Sang

    IPC: A61K9/107 ,  A61K47/34 ,  C08J3/07 ,  C08J3/24 ,  C08G73/02

    Abstract: Disclosed is a preparation method for charge reversal and reversibly crosslinked redox-sensitive nanomicelles, falling within the technical field of biomedical materials. The method comprises: synthesizing thiocinamide from lipoic acid and ethylenediamine under an N,N′-carbonyl diimidazole catalyst; and polymerizing thiocinamide, polyethylene glycol diglycidyl ether and lysine through a nucleophilic addition mechanism to prepare a poly(lysine-co-polyethylene glycol diglycidyl ether-co-thiocinamide) terpolymer. The micelle is endowed with excellent anti-protein nonspecific adsorption and enhanced cell uptake property through a self-assembly and protonation/deprotonation action; and a disulfide bond in lipoyl may form a linear polydisulfide structure under the action of 1,4-dithiothreitol, so that a micelle core is crosslinked, and a crosslinked structure is destroyed in the cell under a redox condition, and controlled release of a drug can be achieved. The Nanomicelle of the present invention is expected to be a carrier of drugs for treating cancers.

    TRIAZINE-CONTAINING PHOTOCURABLE RESIN AND PREPARATION METHOD THEREOF
    5.
    发明申请
    TRIAZINE-CONTAINING PHOTOCURABLE RESIN AND PREPARATION METHOD THEREOF 有权

    公开(公告)号：US20180044301A1

    公开(公告)日：2018-02-15

    申请号：US15551594

    申请日：2016-01-20

    Applicant: Jiangnan University

    Inventor： Ren LIU ,  Xiaopeng ZHANG ,  Zhiquan LI ,  Jingcheng LIU ,  Jing LUO ,  Xiaoya LIU

    IPC: C07D251/70 ,  C08F22/22

    CPC classification number: C07D251/70 ,  C08F22/22 ,  C08F2220/283 ,  C09D167/06

    Abstract: The present invention discloses a triazine-containing photocurable resin and a preparation method thereof. The preparation method of the resin comprises the following steps of: (1) Dissolving the hexamethylolmelamine the unsaturated fatty acids and a catalyst in a solvent, keeping a reaction going, separating and extracting the reaction product after the reaction ends, obtaining triazine-containing fatty acid ester; (2) adding 50 wt % hydrogen peroxide, a catalyst and a solvent, namely methylbenzene, into the triazine-containing fatty acid ester prepared in step (1), keeping a reaction going, obtaining triazine-containing fatty acid ester epoxy resin; (3) adding a polymerization inhibitor and a catalyst into acrylic acid, dropping the triazine-containing fatty acid ester epoxy resin prepared in step (2), keeping a reaction going, and obtaining the triazine-containing photocurable resin. The photocurable resin of the present invention contains a rigid triazine and flexible fatty chains at the same time, so the cured object has excellent comprehensive performance and can be used as the photocurable resin in the field of photosensitive macromolecular materials.

    Method of preparing degradable and environment responsive composite microgels
    6.
    发明申请
    Method of preparing degradable and environment responsive composite microgels 有权

    公开(公告)号：US20210299049A1

    公开(公告)日：2021-09-30

    申请号：US16928186

    申请日：2020-07-14

    Applicant: JIANGNAN UNIVERSITY

    Inventor： Caihua NI ,  Zhenle TIAN ,  Gang WANG ,  Liping ZHANG ,  Ren LIU

    IPC: A61K9/19 ,  C08G63/06 ,  C08J3/075 ,  C08J3/14 ,  A61K31/704

    Abstract: A method of preparing degradable and environment responsive composite microgels, belonging to polymer material synthesis and biomaterial technology fields. Firstly, a copolymer of L-malic acid and 6-hydroxyhexanoate is prepared; then, N,N,N′,N′-tetramethyl cystamine is prepared. The copolymer and N,N,N′,N′-tetramethyl cystamine are mixed in an organic solvent to form a mixed solution which is added into excess distilled water to produce composite microgels. The microgels have advantages of mild preparing conditions, fast reaction speed without catalysts, no impurity remained, and controllable degradation rate. The microgels can load anticancer drug doxorubicin hydrochloride, showing environment responsive controlled release due to introduction of carboxyl groups and disulfide bonds.

    A method for preparation of hybrid amphiphilic star copolymer nano micelles
    7.
    发明申请
    A method for preparation of hybrid amphiphilic star copolymer nano micelles 审中-公开

    公开(公告)号：US20190110987A1

    公开(公告)日：2019-04-18

    申请号：US16159058

    申请日：2018-10-12

    Applicant: JIANGNAN UNIVERSITY

    Inventor： Liping ZHANG ,  Caihua NI ,  Ren LIU ,  He LIU ,  Xinyi DONG

    IPC: A61K9/107 ,  C08G83/00 ,  A61K31/704 ,  C08G81/00

    Abstract: Hybrid amphiphilic star copolymer nano micelles are prepared in the invention. Cage shaped octa(γ-aminopropyl) silsesquioxanes is selected as the inorganic part, and L-glutamic benzyl ester-five membered ring anhydride is ring-opening polymerized by the initiation of amino groups on the surface of cage shaped octa(γ-aminopropyl) silsesquioxanes, producing copolymers with cage shaped octa(γ-aminopropyl) silsesquioxanes as nucleus and poly (L-glutamic-benzyl ester) as arms. The copolymers reacts with monomethoxy poly (ethylene glycol) carboxylic acid by condensation. Finally, the benzyl groups in the side chains of poly (L-glutamic acid-benzyl ester) are converted into hydrazine groups by acylhydrazination to obtain hybrid amphiphilic star copolymer nano micelles. The micelles can load doxorubicin, they are safe to human body and have good application prospects.

    DARK-COLORED SYSTEM PHOTOPOLYMERIZED COMPOSITION
    8.
    发明申请
    DARK-COLORED SYSTEM PHOTOPOLYMERIZED COMPOSITION 有权

    公开(公告)号：US20220220244A1

    公开(公告)日：2022-07-14

    申请号：US17604270

    申请日：2019-10-17

    Applicant: JIANGNAN UNIVERSITY

    Inventor： Ren LIU ,  Xiucheng ZOU

    IPC: C08F283/00 ,  C08F2/48 ,  C08K5/3417 ,  C08K3/04

    Abstract: A dark-colored system photopolymerization composition, comprising: 20-80 phr of photopolymerizable prepolymer, 5-60 phr of photopolymerizable monomer, 0.2-8 phr of photoinitiator, and 0.1-5 phr of melanin, 0.05-5 phr of upconversion materials. The composition can construct photopolymerization under near-infrared irradiation. The dark pigment can avoid the strong absorption of near-infrared light, and the upconversion material can absorb near-infrared light with good penetrating ability and emit ultraviolet or visible light to induce the decomposition of free radicals or ionic photoinitiators in the composition. Then produced active species realize the photopolymerization of dark-colored compositions. The invention increases the depth of photopolymerization of dark-colored compositions and improves the mechanical properties of the polymer, that will broaden application fields of photopolymerization materials.

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