公开(公告)号：US20250074974A1

公开(公告)日：2025-03-06

申请号：US18726333

申请日：2022-12-27

Applicant: Kanaph Therapeutics Inc.

Inventor： Eu Ddeum Chung ,  Soomin Ryu ,  Donggeon Kim ,  Jihoon Chang ,  Byoung Chul Lee

IPC: C07K16/18 ,  A61K38/00 ,  C07K14/71

Abstract: The present invention relates to a fusion protein comprising an anti-C3b antibody or an anti-C5 antibody and an angiogenesis inhibitor, and a composition for treating eye diseases, particularly macular degeneration, by using the same. The protein may not only inhibit complement-related pathways, but can also efficiently regulate angiogenesis. Therefore, the fusion protein dimer can be effectively used to treat and prevent complement-related diseases, particularly eye diseases such as macular degeneration, and thus has high industrial applicability.

公开(公告)号：US12029739B2

公开(公告)日：2024-07-09

申请号：US18407400

申请日：2024-01-08

Applicant: KANAPH THERAPEUTICS INC.

Inventor： Miyeon Kim ,  Dohyun Park ,  Dongsu Kim ,  Kyeongjin Yoon ,  Sungpil Choi ,  Sang Kyun Lim ,  Eu Ddeum Chung ,  Mijung Lee ,  Dahye Jeon ,  Soyeon Jang ,  Kyungik Lee ,  Jinhwan Kim ,  Eunji Kim ,  Jieun Min ,  Kangwoo Lee ,  Jakyung Yoo

IPC: A61K31/497 ,  A61K31/506 ,  A61K31/517 ,  A61K31/53 ,  A61K31/551 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D471/10 ,  C07D491/107 ,  C07D519/00

CPC classification number: A61K31/497 ,  A61K31/506 ,  A61K31/517 ,  A61K31/53 ,  A61K31/551 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D471/10 ,  C07D491/107 ,  C07D519/00

Abstract: The present invention relates to an inhibitor of SHP2, a pharmaceutical composition for preventing or treating a disease related to SHP2 comprising the same, a method for treating and preventing a disease using the same, and a use thereof. Accordingly, the present invention can effectively prevent or treat diseases related to SHP2.