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公开(公告)号：US20230407117A1
公开(公告)日：2023-12-21
申请号：US18210173
申请日：2023-06-15
IPC: C09D11/101 , C09D11/04 , C09D11/107 , C09D11/03 , B33Y70/10
CPC classification number: C09D11/101 , C09D11/04 , B33Y70/10 , C09D11/03 , C09D11/107
Abstract: Described is a biomaterial/carbonate-based ink that comprises a biopolymer-based mixture and bioceramics. The photo- and ionic crosslinkable biopolymer mixture comprises polysaccharide and gelatin-based materials. The bioceramics comprises an apatite and a carbonate. The biopolymer-based mixture is mixed with the bioceramics to form the ink. The ink is capable of being applied under wet or dry conditions. The wet condition is seawater or water or other aqueous solution. The ink is capable to instantly get solidified, when UV or blue light is applied in the presence of the ionic components found in seawater. After photo- or ionic crosslinking, this ink is stable for months.
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公开(公告)号：US20240000994A1
公开(公告)日：2024-01-04
申请号：US18218174
申请日：2023-07-05
Inventor： Charlotte A.E. HAUSER , Hepi Hari SUSAPTO
IPC: A61L26/00
CPC classification number: A61L26/0047 , A61L26/008 , A61L26/0066
Abstract: Described are nanogels suitable for scaffolds for encapsulating human dermal fibroblasts for non-healing chronic wounds. Peptide nanogels Ac-IVZK-NH2 and Ac-IVFK-NH2 are selected and produce silver nanoparticles in situ within the nanogels to assess their efficacy on micropigs with full-thickness excision wounds. The in situ generation of the silver nanoparticles is done solely through UV irradiation and no reducing agent is used. Application of the peptide nanogels on full thickness micropig wounds demonstrate that the scaffolds are biocompatible and do not trigger wound inflammation. This suggests that scaffolds are safe for topical application. A comparison of the effect of both nanogels even without the addition of the silver nanoparticles, reveals that the scaffold itself has a high potential as an antibacterial agent, which may suppress both the inflammatory reaction and the activity of proteases. The effect on wound closure of the peptide nanogels is comparable to standard care hydrogels.
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3.发明公开公开(公告)号：US20230405177A1
公开(公告)日：2023-12-21
申请号：US18218192
申请日：2023-07-05
Inventor： Charlotte A.E. HAUSER , Hepi Hari SUSAPTO
Abstract: Newly developed peptide nanogels provide native cues to human dermal fibroblasts as well as mouse myoblast cells and promote proliferation and extensive network formation in vitro is presented. The results represent an improvement in the fabrication of dermal grafts as well as 3D skin models. In addition, the application of these ultrashort peptide nanogels on full-thickness wounds in a minipig model demonstrated biocompatibility with the minipig skin tissue, as the peptide nanogels did not trigger wound inflammation. Thus, they can be considered as a safe biomaterial for topical applications. It is shown that both peptides are printable. The ability to print peptides and the return of high cell viability within the printed construct will open up the possibility of 3D bioprinting of different cell types in future.
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公开(公告)号：US20220056074A1
公开(公告)日：2022-02-24
申请号：US17401434
申请日：2021-08-13
Inventor： Charlotte A.E. HAUSER , Hepi Hari SUSAPTO
IPC: C07K5/103 , A61L26/00 , C08J3/075 , C08J3/09 , A61L27/22 , A61L27/52 , A61L31/04 , A61L31/14 , C12N5/00
Abstract: The present disclosure relates to ultrashort peptides capable of forming a gel, to a gel comprising a peptide in accordance with the present disclosure, and to a method of preparing such gel. Such gel is a hydrogel or an organogel. The peptides are suitable bioinks for a bioprinter to build 3D structures through 3D printing as well as other applications.
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5.发明公开公开(公告)号：US20240252716A1
公开(公告)日：2024-08-01
申请号：US18565702
申请日：2022-05-30
Inventor： Salwa Ahmed ALSHERI , Charlotte A.E. HAUSER
CPC classification number: A61L27/227 , A61L27/3808 , A61L27/507 , A61L27/52 , A61L2400/12
Abstract: The present disclosure relates generally to a tissue graft capable of undergoing angiogenesis, comprising at least one self-assemble peptide and at least one endothelial cells. The present disclosure further relates to a method of preparing such a tissue graft. The tube-like structure formed by endothelial cells within the graft can promote the growth and proliferation of other type of cell within the same 3D tissue graft and improve the result of tissue implantation.
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Patent Agency Ranking
公开(公告)号：US20230405881A1
公开(公告)日：2023-12-21
申请号：US18210684
申请日：2023-06-16
Inventor： Hamed ALBALAWI , Panagiotis BILALIS , Charlotte A.E. HAUSER
CPC classification number: B29C33/3892 , B33Y30/00 , B33Y80/00 , B29C71/04 , B33Y10/00 , B29C64/118 , B29L2031/00
Abstract: A modified approach for coral restoration by merging 3D printing and molding techniques is presented. This is achieved by 3D scanning live coral specimens, retrieved from sea dives, to obtain a CAD model of the complete coral 3D construction with complex geometries. Select areas of the model are flattened to create a 2D base for micro-fragment adhesion. From the CAD models, disclosed embodiments propose two methods of fabrication. Method A consists of 3D printing the CAD models with commercial thermoplastic materials to create a negative mold, subsequently loaded with synthesized Calcium Carbonate Photoinitiated (CCP) ink to form an eco-friendly coral skeleton. Method B uses syringe-based extrusion 3D printing to directly print a coral skeleton with CCP ink. Both methods are evaluated as a combined proof-of-concept process, 3D CoraPrint, for coral gardening and restoration and providing details required for mimicking coral and bone 3D structures for implantation in bone grafting applications.
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公开(公告)号：US20220054706A1
公开(公告)日：2022-02-24
申请号：US17401542
申请日：2021-08-13
Inventor： Charlotte A.E. HAUSER , Salwa ALSHEHRI , Hepi H. SUSAPTO
Abstract: The present disclosure relates generally to an osteo-tissue graft capable of promoting bone tissue growth and regeneration, comprising at least one self-assemble peptide and mesenchymal stem cells (MSCs) in accordance with the present invention and a method of preparing such an osteo-tissue graft. The grafts are suitable for treatment of bone disorder or damages through tissue engineering, cellular replacement therapies as well as other applications.
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公开(公告)号：US20240261465A1
公开(公告)日：2024-08-08
申请号：US18565644
申请日：2022-06-03
Inventor： Sherin ABDELRAHMAN , Hamed ALBALAWI , Salwa Ahmed ALSHERI , Charlotte A.E. HAUSER
CPC classification number: A61L26/0047 , A61L26/008 , B33Y30/00 , A61L2300/25 , A61L2300/418 , A61L2400/04
Abstract: The present disclosure relates generally to a method of stopping bleeding comprising applying a peptide-based hemostatic material to a bleeding wound, wherein the peptide-based hemostatic material comprises at least one self-assembling ultrashort peptide, and wherein an application of the peptide-based hemostatic material to the bleeding wound produces a coagulation time of less than 40 seconds. The present disclosure also provides a hand-held device for the application of the peptide-based hemostatic material.
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公开(公告)号：US20230405566A1
公开(公告)日：2023-12-21
申请号：US18218162
申请日：2023-07-05
Inventor： Charlotte A.E. HAUSER , Hepi Hari SUSAPTO
IPC: B01J31/18
CPC classification number: B01J31/1805 , B01J2231/64
Abstract: A facile strategy is used to synthesize the gold nanoparticles via a green and simple approach showing self-alignment on the assembled nanofibers of ultrashort oligopeptides as a composite material. A photochemical reduction method is used, without requiring any external chemical reagents for the reduction of gold ions and producing gold nanoparticles of size ca. 5 nm under mild UV light exposure. The specific arrangement of gold nanoparticles on peptide nanofibers may indicate electrostatic interactions of two components and interactions with the amino group of the peptide building block. The gold-peptide nanoparticle composites show the ability as a catalyst to degradation of environmental pollutant p-nitrophenol to p-aminophenol, and the reaction rate constant for catalysis is 0.057 min−1 at a 50-fold dilute sample of 2 mg/mL and 0.72 mM gold concentration in the composites. This colloidal strategy helps researchers to fabricate the metalized bioorganic composites for biomedical and bio-catalysis applications.
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公开(公告)号：US20220055297A1
公开(公告)日：2022-02-24
申请号：US17401800
申请日：2021-08-13
Inventor： Charlotte A.E. HAUSER , Zainab KHAN , Kowther KAHIN , Dana ALHATTAB
IPC: B29C64/209 , B33Y30/00 , B33Y70/00 , B29C64/336
Abstract: The present disclosure relates to a coaxial nozzle for building a 3D tissue model. Accordingly, a nozzle for 3D tissue bioprinting may include at least one buffer solution inlet, at least one peptide inlet, at least one cell inlet, and a mixing chamber. The least one buffer solution inlet is attached to the at least one peptide inlet. The at least one cell inlet is attached to the at least one peptide inlet. The at least one buffer solution inlet may be attached from a side of the at least one peptide inlet, and the at least one cell inlet may be disposed externally and attached at an angle to the at least one peptide inlet.
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