公开(公告)号：US20190282298A1

公开(公告)日：2019-09-19

申请号：US16412379

申请日：2019-05-14

Applicant: Kona Medical, Inc.

Inventor： Michael Gertner

IPC: A61B18/14

Abstract: A method to apply a nerve inhibiting cloud surrounding a blood vessel includes creating a treatment plan, wherein the treatment plan prescribes application of the nerve inhibiting cloud towards at least a majority portion of a circumference of a blood vessel wall, and applying the nerve inhibiting cloud towards the majority portion of the circumference of the blood vessel wall for a time sufficient to inhibit a function of a nerve that surrounds the blood vessel wall.

公开(公告)号：US20160059044A1

公开(公告)日：2016-03-03

申请号：US14939670

申请日：2015-11-12

Applicant: Kona Medical, Inc.

Inventor： Michael Gertner

IPC: A61N7/00 ,  A61B5/00

CPC classification number: A61B18/1492 ,  A61B5/01 ,  A61B5/055 ,  A61B90/50 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/048 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0021 ,  A61N2007/0078

Abstract: A method to apply a nerve inhibiting cloud surrounding a blood vessel includes creating a treatment plan, wherein the treatment plan prescribes application of the nerve inhibiting cloud towards at least a majority portion of a circumference of a blood vessel wall, and applying the nerve inhibiting cloud towards the majority portion of the circumference of the blood vessel wall for a time sufficient to inhibit a function of a nerve that surrounds the blood vessel wall.

Abstract translation: 应用围绕血管的神经抑制云的方法包括创建治疗计划，其中治疗计划规定将神经抑制云应用于血管壁的圆周的至少大部分，并施加神经抑制云 朝向血管壁的圆周的大部分，足以抑制围绕血管壁的神经的功能。

公开(公告)号：US20140194785A1

公开(公告)日：2014-07-10

申请号：US14207516

申请日：2014-03-12

Applicant: Kona Medical, Inc.

Inventor： Michael Gertner

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61B5/0225 ,  A61B5/0263 ,  A61B5/055 ,  A61B5/061 ,  A61B5/201 ,  A61B5/412 ,  A61B5/4528 ,  A61B5/4839 ,  A61B5/489 ,  A61B5/4893 ,  A61B6/03 ,  A61B6/032 ,  A61B6/037 ,  A61B6/487 ,  A61B6/504 ,  A61B6/506 ,  A61B8/00 ,  A61B8/06 ,  A61B8/08 ,  A61B8/0841 ,  A61B8/0891 ,  A61B8/14 ,  A61B8/4245 ,  A61B8/485 ,  A61B8/488 ,  A61B90/37 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2090/378 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/0622 ,  A61N7/02 ,  A61N2005/063 ,  A61N2007/0026 ,  A61N2007/003 ,  A61N2007/0052 ,  A61N2007/0078

Abstract: A system for treatment includes a focused ultrasound energy source for placement outside a patient, wherein the focused ultrasound energy source is configured to deliver ultrasound energy towards a blood vessel with a surrounding nerve that is a part of an autonomic nervous system inside the patient, and wherein the focused ultrasound energy source is configured to deliver the ultrasound energy from outside the patient to the nerve located inside the patient to treat the nerve.

公开(公告)号：US20130138018A1

公开(公告)日：2013-05-30

申请号：US13751133

申请日：2013-01-27

Applicant: Kona Medical, Inc.

Inventor： Michael Gertner

IPC: A61N7/00

CPC classification number: A61N5/062 ,  A61B5/4035 ,  A61B5/4041 ,  A61B5/4047 ,  A61B5/412 ,  A61B5/4528 ,  A61B6/506 ,  A61B8/06 ,  A61B8/0833 ,  A61B8/0841 ,  A61B8/4245 ,  A61B8/485 ,  A61B34/20 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2090/374 ,  A61B2090/378 ,  A61N5/0601 ,  A61N5/0622 ,  A61N7/00 ,  A61N7/02 ,  A61N7/022 ,  A61N2005/0612 ,  A61N2005/0659 ,  A61N2007/0026 ,  A61N2007/003 ,  A61N2007/0039 ,  A61N2007/0078 ,  A61N2007/025

Abstract: A method of treatment includes delivering an agent into a patient, and providing energy inside the patient so that the energy can interact with the agent to treat a nerve. A system for treatment includes a source of agent for delivery into a patient, and an energy source for providing energy inside the patient so that the energy can interact with the agent to treat a nerve.

公开(公告)号：US20160074677A1

公开(公告)日：2016-03-17

申请号：US14789769

申请日：2015-07-01

Applicant: Kona Medical, Inc.

Inventor： Michael Gertner

IPC: A61N7/00 ,  A61B6/03 ,  A61B8/08

CPC classification number: A61N7/00 ,  A61B5/055 ,  A61B6/032 ,  A61B6/506 ,  A61B8/06 ,  A61B8/0833 ,  A61B8/0841 ,  A61B8/0891 ,  A61B8/483 ,  A61B8/488 ,  A61B18/1492 ,  A61B18/18 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2034/2072 ,  A61B2034/2074 ,  A61B2090/374 ,  A61B2090/378 ,  A61B2090/3929 ,  A61B2090/3958 ,  A61B2090/3975 ,  A61N7/02 ,  A61N2007/003 ,  A61N2007/0078

Abstract: In some embodiments, sympathetic nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some embodiments, different types of energy sources are utilized singly or combined with one another. In some embodiments, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents.

公开(公告)号：US09125642B2

公开(公告)日：2015-09-08

申请号：US14099834

申请日：2013-12-06

Applicant: Kona Medical, Inc.

Inventor： Michael Gertner

IPC: A61B8/06 ,  A61B18/04 ,  A61N7/02 ,  A61B8/08 ,  A61B19/00 ,  A61N7/00 ,  A61B18/00 ,  A61B6/00 ,  A61B8/00

CPC classification number: A61B18/04 ,  A61B5/0225 ,  A61B5/055 ,  A61B5/4041 ,  A61B5/412 ,  A61B5/4528 ,  A61B5/4839 ,  A61B5/489 ,  A61B5/4893 ,  A61B6/03 ,  A61B6/032 ,  A61B6/037 ,  A61B6/506 ,  A61B8/00 ,  A61B8/06 ,  A61B8/08 ,  A61B8/0833 ,  A61B8/0841 ,  A61B8/4245 ,  A61B8/485 ,  A61B34/20 ,  A61B90/37 ,  A61B2018/00982 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2090/378 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/0622 ,  A61N7/00 ,  A61N7/02 ,  A61N7/022 ,  A61N2005/063 ,  A61N2007/0026 ,  A61N2007/003 ,  A61N2007/0039 ,  A61N2007/0078 ,  A61N2007/025

Abstract: In some embodiments, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some embodiments, different types of energy sources are utilized singly or combined with one another. In some embodiments, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents.

Abstract translation: 在一些实施方案中，围绕动脉或通向器官的神经以能量来靶向以校正或调节生理过程。 在一些实施例中，不同类型的能量源单独使用或彼此组合使用。 在一些实施方案中，由能量源激活的生物活性剂或装置被输送到感兴趣的区域，并且能量被这种试剂增强。

公开(公告)号：US20150202466A1

公开(公告)日：2015-07-23

申请号：US14562477

申请日：2014-12-05

Applicant: KONA MEDICAL, INC.

Inventor： Michael Gertner

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61B5/0225 ,  A61B5/0263 ,  A61B5/055 ,  A61B5/201 ,  A61B5/412 ,  A61B5/4528 ,  A61B5/4839 ,  A61B5/489 ,  A61B5/4893 ,  A61B6/032 ,  A61B6/037 ,  A61B6/487 ,  A61B6/504 ,  A61B6/506 ,  A61B8/06 ,  A61B8/0841 ,  A61B8/0891 ,  A61B8/4245 ,  A61B8/485 ,  A61B8/488 ,  A61B90/37 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2090/378 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/0622 ,  A61N7/02 ,  A61N2005/063 ,  A61N2007/0026 ,  A61N2007/003 ,  A61N2007/0078

Abstract: A method to deliver focused ultrasound energy from a position outside a skin of a patient to a nerve surrounding a blood vessel, includes placing the patient on a table in a substantially flat position, moving a transducer into a position inferior to ribs, superior to an iliac crest, and lateral to a spine of the patient, maintaining the transducer at the position relative to the patient, and delivering focused ultrasound energy through the skin of the patient without traversing bone, wherein the direction of the focused ultrasound is directed from a lower torso to an upper torso of the patient.

Abstract translation: 将聚焦超声能量从患者皮肤外部的位置输送到血管周围的神经的方法包括将患者放置在基本上平坦的位置的台上，将换能器移动到低于肋的位置，优于 髂嵴和患者的脊柱侧面，将换能器保持在相对于患者的位置，并且将聚焦的超声波能量穿过患者的皮肤而不穿过骨骼，其中聚焦超声波的方向指向下方 躯干到患者的上身。

公开(公告)号：US20140194784A1

公开(公告)日：2014-07-10

申请号：US14207511

申请日：2014-03-12

Applicant: KONA MEDICAL, INC.

Inventor： Michael Gertner

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61B5/0225 ,  A61B5/0263 ,  A61B5/055 ,  A61B5/061 ,  A61B5/201 ,  A61B5/412 ,  A61B5/4528 ,  A61B5/4839 ,  A61B5/489 ,  A61B5/4893 ,  A61B6/03 ,  A61B6/032 ,  A61B6/037 ,  A61B6/487 ,  A61B6/504 ,  A61B6/506 ,  A61B8/00 ,  A61B8/06 ,  A61B8/08 ,  A61B8/0841 ,  A61B8/0891 ,  A61B8/14 ,  A61B8/4245 ,  A61B8/485 ,  A61B8/488 ,  A61B90/37 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2090/378 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/0622 ,  A61N7/02 ,  A61N2005/063 ,  A61N2007/0026 ,  A61N2007/003 ,  A61N2007/0052 ,  A61N2007/0078

Abstract: A system for treatment includes a focused ultrasound energy source for placement outside a patient, wherein the focused ultrasound energy source is configured to deliver ultrasound energy towards a blood vessel with a surrounding nerve that is a part of an autonomic nervous system inside the patient, and wherein the focused ultrasound energy source is configured to deliver the ultrasound energy from outside the patient to the nerve located inside the patient to treat the nerve.

Abstract translation: 一种用于治疗的系统包括用于放置在患者外部的聚焦超声能量源，其中所述聚焦超声能量被配置为将周围神经作为患者内部的自主神经系统的一部分向血管递送超声能量，以及 其中所述聚焦超声能量源被配置为将超声能量从患者外部递送到位于患者内部的神经以治疗神经。

公开(公告)号：US20130110012A1

公开(公告)日：2013-05-02

申请号：US13657725

申请日：2012-10-22

Applicant: Kona Medical, Inc.

Inventor： Michael Gertner

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61B5/055 ,  A61B6/032 ,  A61B6/506 ,  A61B8/06 ,  A61B8/0833 ,  A61B8/0841 ,  A61B8/0891 ,  A61B8/483 ,  A61B8/488 ,  A61B18/1492 ,  A61B18/18 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2034/2072 ,  A61B2034/2074 ,  A61B2090/374 ,  A61B2090/378 ,  A61B2090/3929 ,  A61B2090/3958 ,  A61B2090/3975 ,  A61N7/02 ,  A61N2007/003 ,  A61N2007/0078

Abstract: In some embodiments, sympathetic nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some embodiments, different types of energy sources are utilized singly or combined with one another. In some embodiments, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents.

Abstract translation: 在一些实施方案中，围绕动脉或通向器官的交感神经以能量来靶向以校正或调节生理过程。 在一些实施例中，不同类型的能量源单独使用或彼此组合使用。 在一些实施方案中，由能量源激活的生物活性剂或装置被输送到感兴趣的区域，并且能量被这种试剂增强。

公开(公告)号：US20140336497A1

公开(公告)日：2014-11-13

申请号：US14207526

申请日：2014-03-12

Applicant: KONA MEDICAL, INC.

Inventor： Michael Gertner

IPC: A61N7/00 ,  A61B5/055 ,  A61B5/06 ,  A61B8/14

CPC classification number: A61N7/00 ,  A61B5/0225 ,  A61B5/0263 ,  A61B5/055 ,  A61B5/061 ,  A61B5/201 ,  A61B5/412 ,  A61B5/4528 ,  A61B5/4839 ,  A61B5/489 ,  A61B5/4893 ,  A61B6/03 ,  A61B6/032 ,  A61B6/037 ,  A61B6/487 ,  A61B6/504 ,  A61B6/506 ,  A61B8/00 ,  A61B8/06 ,  A61B8/08 ,  A61B8/0841 ,  A61B8/0891 ,  A61B8/14 ,  A61B8/4245 ,  A61B8/485 ,  A61B8/488 ,  A61B90/37 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2090/378 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/0622 ,  A61N7/02 ,  A61N2005/063 ,  A61N2007/0026 ,  A61N2007/003 ,  A61N2007/0052 ,  A61N2007/0078

Abstract: A system for treatment includes a focused ultrasound energy source for placement outside a patient, wherein the focused ultrasound energy source is configured to deliver ultrasound energy towards a blood vessel with a surrounding nerve that is a part of an autonomic nervous system inside the patient, and wherein the focused ultrasound energy source is configured to deliver the ultrasound energy from outside the patient to the nerve located inside the patient to treat the nerve.

Abstract translation: 一种用于治疗的系统包括用于放置在患者外部的聚焦超声能量源，其中所述聚焦超声能量被配置为将周围神经作为患者内部的自主神经系统的一部分向血管递送超声能量，以及 其中所述聚焦超声能量源被配置为将超声能量从患者外部递送到位于患者内部的神经以治疗神经。