公开(公告)号：US11478798B2

公开(公告)日：2022-10-25

申请号：US16650218

申请日：2018-10-02

Applicant: Khalifa University of Science and Technology

Inventor： Jeremy C M Teo ,  Cesare Stefanini ,  Amal Abdullah ,  Bisan Samara ,  Aya Shanti

IPC: B01L3/00 ,  G01N33/50

Abstract: A 3D microfluidic device for use as an in vitro lymph node is described. The microfluidic device has a body with a semi-circular inner wall and a first channel located adjacent along the semi-circular inner wall, the first channel corresponding to a subcapsular sinus region of a lymph node, a second channel located adjacent the first channel, the second channel corresponding to a reticular network, and a bottom cavity and top cavity, centrally located, corresponding to a paracortex and follicle of a lymph node, respectively. The various compartments of the device are separated by circumferentially and horizontally located rows of micro-pillars. A lab-on-a-chip device incorporating the microfluidic device is also described.