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公开(公告)号：US20050032836A1
公开(公告)日：2005-02-10
申请号：US10635232
申请日：2003-08-06
Applicant: Kristyn Greco , James Wright
Inventor： Kristyn Greco , James Wright
IPC: A61K31/445 , C07D211/52 , C07D211/54
CPC classification number: C07D211/52 , A61K31/445
Abstract: The invention relates to the discovery that pamoate salts of haloperidol and aripiprazole result in a good to superior long acting and/or extended release profile. Thus, in one aspect of the invention, the invention includes pamoate salts of haloperidol or aripiprazole. Preferably, the pamoate salt is characterized by a ratio of haloperidol to pamoate of 1:1 or 2:1. The pamoate salt can be crystalline, such as a needle or a dense crystal, such as described in the Figures. The invention further relates to methods of treating an individual in need thereof comprising administering a pharmaceutical composition comprising a pamoate salt of haloperidol and aripiprazole.
Abstract translation: 本发明涉及氟哌啶醇和阿立哌唑的双羟萘酸盐产生优异的长效和/或延长释放特征的发现。 因此，在本发明的一个方面，本发明包括氟哌啶醇或阿立哌唑的双羟萘酸盐。 优选地，双羟萘酸盐的特征在于氟哌啶醇与双羟萘酸的比例为1:1或2:1。 双羟萘酸盐可以是结晶的，例如针或致密晶体，如图中所述。 本发明还涉及治疗有需要的个体的方法，其包括施用包含氟哌啶醇和阿立哌唑的双羟萘酸盐的药物组合物。
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公开(公告)号：US06987111B2
公开(公告)日：2006-01-17
申请号：US10635232
申请日：2003-08-06
Applicant: Kristyn Greco , James Wright
Inventor： Kristyn Greco , James Wright
IPC: A61K31/445 , A61K31/495
CPC classification number: C07D211/52 , A61K31/445
Abstract: The invention relates to the discovery that pamoate salts of haloperidol and aripiprazole result in a good to superior long acting and/or extended release profile. Thus, in one aspect of the invention, the invention includes pamoate salts of haloperidol or aripiprazole. Preferably, the pamoate salt is characterized by a ratio of haloperidol to pamoate of 1:1 or 2:1. The pamoate salt can be crystalline, such as a needle or a dense crystal, such as described in the Figures.The invention further relates to methods of treating an individual in need thereof comprising administering a pharmaceutical composition comprising a pamoate salt of haloperidol and aripiprazole.
Abstract translation: 本发明涉及氟哌啶醇和阿立哌唑的双羟萘酸盐产生优异的长效和/或延长释放特征的发现。 因此，在本发明的一个方面，本发明包括氟哌啶醇或阿立哌唑的双羟萘酸盐。 优选地，双羟萘酸盐的特征在于氟哌啶醇与双羟萘酸的比例为1:1或2:1。 双羟萘酸盐可以是结晶的，例如针或致密晶体，如图中所述。 本发明还涉及治疗有需要的个体的方法，其包括施用包含氟哌啶醇和阿立哌唑的双羟萘酸盐的药物组合物。
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公开(公告)号：US20060040922A1
公开(公告)日：2006-02-23
申请号：US11252862
申请日：2005-10-18
Applicant: Kristyn Greco , James Wright
Inventor： Kristyn Greco , James Wright
IPC: A61K31/551 , A61K31/496 , A61K31/445
CPC classification number: C07D211/52 , A61K31/445
Abstract: The invention relates to the discovery that pamoate salts of haloperidol and aripiprazole result in a good to superior long acting and/or extended release profile. Thus, in one aspect of the invention, the invention includes pamoate salts of haloperidol or aripiprazole. Preferably, the pamoate salt is characterized by a ratio of haloperidol to pamoate of 1:1 or 2:1. The pamoate salt can be crystalline, such as a needle or a dense crystal, such as described in the Figures. The invention further relates to methods of treating an individual in need thereof comprising administering a pharmaceutical composition comprising a pamoate salt of haloperidol and aripiprazole.
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公开(公告)号：US09308179B2
公开(公告)日：2016-04-12
申请号：US13556647
申请日：2012-07-24
Applicant: Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright
Inventor： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright
CPC classification number: A61K9/5153 , A61K9/0019 , A61K9/1641 , A61K31/337 , A61K31/436 , A61K31/475 , A61K31/519 , A61K47/542 , A61K47/593 , A61K47/60 , A61K47/6925 , A61K47/6937 , B82Y5/00
Abstract: The present disclosure is directed in part to a biocompatible nanoparticle composition comprising a plurality of non-colloidal long circulating nanoparticles, each comprising a α-hydroxy polyester-co-polyether and a therapeutic agent, wherein such disclosed compositions provide a therapeutic effect for at least 12 hours.
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5.发明授权Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers 有权具有高玻璃化转变温度或高分子量共聚物的治疗性聚合物纳米颗粒组合物公开(公告)号：US08518963B2
公开(公告)日：2013-08-27
申请号：US13372036
申请日：2012-02-13
Applicant: Mir Mukkaram Ali , Abhimanyu Sabnis , David Dewitt , Greg Troiano , James Wright , Maria Figueiredo , Michael Figa , Christina Van Geen Hoven , Young-Ho Song , Jason Auer , Tarikh Christopher Campbell
Inventor： Mir Mukkaram Ali , Abhimanyu Sabnis , David Dewitt , Greg Troiano , James Wright , Maria Figueiredo , Michael Figa , Christina Van Geen Hoven , Young-Ho Song , Jason Auer , Tarikh Christopher Campbell
CPC classification number: G01N25/4866 , A61K9/0019 , A61K9/146 , A61K9/5153 , A61K31/00 , A61K31/337 , A61K31/427 , A61K31/436 , A61K31/475 , A61K31/573 , A61K31/58 , A61K31/585 , A61K31/69 , A61K47/34
Abstract: The present disclosure relates in part to pharmaceutical compositions comprising polymeric nanoparticles having certain glass transition temperatures. Other aspects of the invention include methods of making such nanoparticles.
Abstract translation: 本公开部分涉及包含具有某些玻璃化转变温度的聚合物纳米颗粒的药物组合物。 本发明的其它方面包括制备这种纳米颗粒的方法。
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Patent Agency Ranking
公开(公告)号：US20130023898A9
公开(公告)日：2013-01-24
申请号：US12173963
申请日：2008-07-16
Applicant: Yulun Wang , Modjtaba Ghodoussi , Darrin Uecker , James Wright , Amante Mangaser , Ranjan Mukherjee
Inventor： Yulun Wang , Modjtaba Ghodoussi , Darrin Uecker , James Wright , Amante Mangaser , Ranjan Mukherjee
IPC: A61B19/00
CPC classification number: G09B23/28 , A61B34/30 , A61B34/35 , A61B34/37 , A61B34/70 , A61B34/76 , A61B34/77 , A61B90/06 , A61B90/361 , A61B2017/00707 , A61B2034/305 , A61B2090/064 , G05B15/02 , G06F19/00 , G06F19/3418
Abstract: A medical system that allows a mentor to teach a pupil how to use a robotically controlled medical instrument. The system may include a first handle that can be controlled by a mentor to move the medical instrument. The system may further have a second handle that can be moved by a pupil to control the same instrument. Deviations between movement of the handles by the mentor and the pupil can be provided as force feedback to the pupil and mentor handles. The force feedback pushes the pupil's hand to correspond with the mentor's handle movement. The force feedback will also push the mentor's hand to provide information to the mentor on pupil's movements. The mentor is thus able to guide the pupil's hands through force feedback of the pupil handles to teach the pupil how to use the system.
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7.发明授权Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same 有权包括长春花生物碱的治疗性聚合物纳米颗粒及其制备和使用方法公开(公告)号：US08318211B2
公开(公告)日：2012-11-27
申请号：US12485467
申请日：2009-06-16
Applicant: Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
Inventor： Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
CPC classification number: A61K9/1647 , A61K9/14 , A61K9/1694 , A61K9/19 , A61K9/5153 , A61K31/4745 , A61K31/475 , A61K31/55 , A61K47/26
Abstract: The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 1 to about 20 weight percent of a vinca alkaloid; and about 50 to about 99 weight percent biocompatible polymer.
Abstract translation: 本公开一般涉及治疗性纳米颗粒。 本文公开的示例性纳米颗粒可包括约1至约20重量％的长春花生物碱; 和约50至约99重量％的生物相容性聚合物。
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8.发明申请公开(公告)号：US20120288541A1
公开(公告)日：2012-11-15
申请号：US13553210
申请日：2012-07-19
Applicant: Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
Inventor： Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
IPC: A61K9/14 , A61P35/00 , A61K31/337 , B82Y5/00
CPC classification number: A61K47/34 , A61J3/00 , A61K9/10 , A61K9/107 , A61K9/1647 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/337 , A61K31/4355 , A61K31/436 , A61K31/437 , A61K31/439 , A61K31/475 , A61K31/704 , A61K31/7068 , A61K47/6915 , A61K47/6925 , A61K47/6937 , B82Y5/00 , C07C59/08 , Y10S977/773
Abstract: The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol. Other aspects of the invention include methods of making such nanoparticles.
Abstract translation: 本公开内容通常涉及具有约0.2至约35重量％的治疗剂的纳米颗粒; 和约10至约99重量％的生物相容性聚合物，例如二嵌段聚（乳酸） - 聚（乙烯）二醇。 本发明的其它方面包括制备这种纳米颗粒的方法。
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9.发明授权Method for operating a medical robotic system by stopping movement of a surgical instrument about a pivot point or issuing a warning if the pivot point moves beyond a threshold value 有权用于通过停止手术器械关于枢转点的运动来操作医疗机器人系统的方法或者如果枢转点移动超过阈值则发出警告公开(公告)号：US07785320B2
公开(公告)日：2010-08-31
申请号：US12051957
申请日：2008-03-20
Applicant: Yulun Wang , Darrin R Uecker , Jeff Wilson , Keith Philip Laby , Steve Jordan , James Wright
Inventor： Yulun Wang , Darrin R Uecker , Jeff Wilson , Keith Philip Laby , Steve Jordan , James Wright
IPC: A61B17/00
CPC classification number: A61B17/11 , A61B17/0469 , A61B17/29 , A61B34/30 , A61B34/35 , A61B34/37 , A61B34/70 , A61B34/71 , A61B34/72 , A61B34/75 , A61B34/76 , A61B34/77 , A61B46/10 , A61B50/00 , A61B90/361 , A61B2017/00199 , A61B2017/00243 , A61B2017/00252 , A61B2017/0046 , A61B2017/00477 , A61B2017/00703 , A61B2017/00973 , A61B2017/1107 , A61B2017/1135 , A61B2017/2927 , A61B2017/2929 , A61B2034/2059 , A61B2034/742 , A61B2090/064 , B25J9/1689 , G05B2219/45119
Abstract: A system for performing minimally invasive cardiac procedures. The system includes a pair of surgical instruments that are coupled to a pair of robotic arms. The instruments have end effectors that can be manipulated to hold and suture tissue. The robotic arms are coupled to pair of master handles by a controller. The handles can be moved by the surgeon to produce a corresponding movement of the end effectors. The controller controls and limits movement of robotic arms relative to the patient.
Abstract translation: 用于执行微创心脏手术的系统。 该系统包括耦合到一对机器人臂的一对外科器械。 仪器具有能够被操纵以保持和缝合组织的末端效应器。 机器臂通过控制器耦合到一对主手柄。 手柄可由外科医生移动以产生末端执行器的相应运动。 控制器控制和限制机器人臂相对于患者的运动。
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10.发明申请公开(公告)号：US20100216804A1
公开(公告)日：2010-08-26
申请号：US12638297
申请日：2009-12-15
Applicant: Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright , Susan Low
Inventor： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright , Susan Low
IPC: A61K9/14 , A61K31/337 , A61K31/4745 , A61K31/519 , A61K31/436 , A61P35/00
CPC classification number: A61K9/5153 , A61K9/0019 , A61K9/1641 , A61K31/337 , A61K31/436 , A61K31/475 , A61K31/519 , A61K47/542 , A61K47/593 , A61K47/60 , A61K47/6925 , A61K47/6937 , B82Y5/00
Abstract: The present disclosure is directed in part to a biocompatible nanoparticle composition comprising a plurality of non-colloidal long circulating nanoparticles, each comprising a α-hydroxy polyester-co-polyether and a therapeutic agent, wherein such disclosed compositions provide a therapeutic effect for at least 12 hours.
Abstract translation: 本公开部分地涉及生物相容性纳米颗粒组合物，其包含多个非胶体长循环纳米颗粒，每个非胶体长循环纳米颗粒包含α-羟基聚酯 - 共聚醚和治疗剂，其中所述公开的组合物至少提供治疗效果 12小时。
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