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公开(公告)号：US20190101736A1
公开(公告)日：2019-04-04
申请号：US16146991
申请日：2018-09-28
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Leng-Chun CHEN , Yunlu ZOU , Allen OLSON , Peyman NAJMABADI , Greg CRANDALL , Nicholas NEWBERG , Aaron STEARRETT
Abstract: Two-pass capture of a macro image. In an embodiment, a scanning apparatus comprises a stage, a high-resolution camera, and a lens that provides a field of view, substantially equal in width to a slide width, to the high-resolution camera. The apparatus also comprises a first illumination system for transmission-mode illumination, and a second illumination system for reflection-mode illumination. Processor(s) move the stage in a first direction to capture a first macro image of a specimen during a single pass while the field of view is illuminated by the first illumination system, and move the stage in a second direction to capture a second macro image of the specimen during a single pass while the field of view is illuminated by the second illumination system. The processor(s) identify artifacts in the second macro image, and, based on those artifacts, correct the first macro image to generate a modified first macro image.
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公开(公告)号：US20190101553A1
公开(公告)日：2019-04-04
申请号：US16152192
申请日：2018-10-04
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Nicholas NEWBERG , Prentash DJELOSEVIC
Abstract: A slide rack carousel is provided that includes a base that is configured to support a plurality of slide rack spacers that extend upward from an upper surface of the base. Adjacent slide rack spacers define a slide rack slot of a predetermined size. The plurality of slide rack spacers may include slide rack spacers of varying sizes and therefore a plurality slide rack slot sizes can be selectively configured on the carousel in accordance with the positioning and size of the plurality of slide rack spacers that are attached to the base of the carousel. Accordingly, a desired number of 1×3 slide rack slots and a desired number of 2×3 slide rack slots can be configured on the base of the slide rack carousel.
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公开(公告)号：US20210165203A1
公开(公告)日：2021-06-03
申请号：US17169353
申请日：2021-02-05
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Nicholas NEWBERG
Abstract: A fixed reference edge system that guides a glass slide from a slot of a slide rack onto a scanning stage and guides the glass slide from the scanning stage into the slot of the slide rack. In an embodiment, the fixed reference edge has a first side that is parallel to a side of the slot of the slide rack. The system comprises an assembly that includes a push bar configured to push the slide from the slot onto the scanning stage, and a pull bar configured to pull the slide from the scanning stage into the slot of the slide rack. When the slide is pulled into the slide rack, the long edge of the slide is pressed against the first side of the fixed reference edge to maintain a parallel orientation between the slide and the slot of the slide rack.
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公开(公告)号：US20210165004A1
公开(公告)日：2021-06-03
申请号：US17150618
申请日：2021-01-15
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Nicholas NEWBERG
Abstract: A digital slide scanning apparatus includes a safety light curtain that operates to disable the motor that rotates the carousel when the presence of an object (e.g., the fingers of an operator) is detected within a predetermined area of the carousel. The light curtain also operates to disable the motor that rotates the carousel when an improperly positioned glass slide or slide rack is detected. The digital slide scanning apparatus also includes a multi-color status indicator for each rack slot that indicates the rack slot location of an improperly positioned glass slide or slide rack.
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公开(公告)号：US20190170777A1
公开(公告)日：2019-06-06
申请号：US16206379
申请日：2018-11-30
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Nicholas NEWBERG , Prentash DJELOSEVIC
Abstract: A digital slide scanning apparatus slide rack carousel allows continuous loading and unloading of slide racks into the carousel while the digital slide scanning apparatus is simultaneously digitizing glass slides. The slide rack carousel includes a base having an interior portion of its upper surface at an angle. The slide rack carousel also includes plural rack spacers extending upward from the base and adjacent rack spacers define a rack slot. Each rack spacer also includes a rack stopper on each side such that adjacent rack spacers have rack stoppers facing each other. The rack stoppers prevent a slide rack from moving further toward the center of the carousel than desired.
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Patent Agency Ranking
公开(公告)号：US20180188517A1
公开(公告)日：2018-07-05
申请号：US15858487
申请日：2017-12-29
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Yunlu ZOU , Nicholas NEWBERG , Gregory CRANDALL
CPC classification number: G02B21/361 , G02B21/002 , G02B21/245 , G02B21/26 , G02B21/34 , G02B21/365 , G06T2207/10056
Abstract: A digital pathology imaging apparatus includes a single line scan camera sensor optically coupled with first and second optical paths. In a first embodiment, transmission mode illumination and oblique mode illumination are simultaneously used during a single stage movement that captures a low resolution macro image of the entire sample area and the entire label area of the slide via the first optical path. In a second embodiment, transmission mode illumination is used during a first stage movement that captures a low resolution macro image of at least the entire sample area via the first optical path and oblique mode illumination is used during a second stage movement that captures a low resolution macro image of at least the entire label area via the first optical path.
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公开(公告)号：US20230174321A1
公开(公告)日：2023-06-08
申请号：US18102993
申请日：2023-01-30
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Nicholas NEWBERG , Prentash DJELOSEVIC , David RYBKA
CPC classification number: B65G47/902 , B25J9/0093 , B25J15/0028 , B25J15/0033 , G01N21/645 , G01N35/04 , G01N35/00029 , G01N35/0099 , G01N2035/0441
Abstract: A slide rack gripper apparatus is provided that simultaneously conveys a plurality of glass slides in the protection of a slide rack within a digital slide scanning apparatus. The slide rack gripper apparatus conveys the plurality of glass slides from a slide rack carousel to a scanning stage for processing. The slide rack gripper includes a first motor attached to a base configured to drive a finger mount attached to the base along a first linear axis. The slide rack gripper apparatus also includes a second motor attached to the finger mount and configured to drive opposing gripper fingers attached to the finger mount along a second linear axis. The second motor is also configured to drive individual gripper fingers along a third linear axis to move the gripper fingers toward each other and away from each other to grasp or release a slide rack.
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公开(公告)号：US20210165008A1
公开(公告)日：2021-06-03
申请号：US17153746
申请日：2021-01-20
Applicant: LEICA BIOSYSTEMS IMAGING, INC.
Inventor： Nicholas NEWBERG
Abstract: A slide rack clamp apparatus that secures a slide rack in a digital slide scanning apparatus. In an embodiment, the slide rack clamp apparatus includes an upper clamp and a lower clamp. Each clamp comprises one or more clamp projections, which are configured to engage one or more recesses in engagement surfaces of a plurality of different slide racks from different manufacturers. The lower clamp is driven by a motor along a linear axis to engage the lower clamp projections with the one or more slide rack recesses of the bottom surface of the slide rack. The motor drives the lower clamp and the engaged slide rack upward to engage the one or more slide rack recesses of the top surface of the slide rack with the clamp projections of the upper clamp to fully engage the slide rack between the upper clamp and the lower clamp.
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公开(公告)号：US20200225255A1
公开(公告)日：2020-07-16
申请号：US16624158
申请日：2018-11-30
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Nicholas NEWBERG
Abstract: A slide rack clamp apparatus that secures a slide rack in a digital slide scanning apparatus. In an embodiment, the slide rack clamp apparatus includes an upper clamp and a lower clamp. Each clamp comprises one or more clamp projections, which are configured to engage one or more recesses in engagement surfaces of a plurality of different slide racks from different manufacturers. The lower clamp is driven by a motor along a linear axis to engage the lower clamp projections with the one or more slide rack recesses of the bottom surface of the slide rack. The motor drives the lower clamp and the engaged slide rack upward to engage the one or more slide rack recesses of the top surface of the slide rack with the clamp projections of the upper clamp to fully engage the slide rack between the upper clamp and the lower clamp.
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公开(公告)号：US20200217862A1
公开(公告)日：2020-07-09
申请号：US16624724
申请日：2019-03-01
Applicant: Leica Biosystems Imaging, Inc.
Inventor： Nicholas NEWBERG , Benjamin SIEHL , Markus WITTMANN , Markus SHARPE
Abstract: A power off delay system and method is configured to delay termination of electrical power to a digital pathology device in a power off condition. If the apparatus includes a UPS, the power off delay system and method delays termination of electrical power when a power switch is turned off and when a catastrophic power failure occurs. During the delay of the termination of electrical power, the digital pathology device is configured to control the scanning stage system and the glass slide conveyor system and the slide rack conveyor system to place each of these systems into a known state and position all glass slides into a known position prior to the termination of electrical power to the digital pathology device. This allows the digital pathology device to resume normal operation upon power up.
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