公开(公告)号：US20160223461A1

公开(公告)日：2016-08-04

申请号：US15095397

申请日：2016-04-11

Applicant: LUMENCOR, INC.

Inventor： CLAUDIA B JAFFE ,  STEVEN M JAFFE ,  DAVID LARSEN

IPC: G01N21/64 ,  F21V23/04 ,  G01J1/42

CPC classification number: G01N21/645 ,  F21V23/0457 ,  G01J1/4257 ,  G01N21/64 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6439 ,  G01N2201/061 ,  H05B33/0869

Abstract: A system and method for metered dosage illumination in a bioanalysis or other system. In accordance with an embodiment, an illumination system or subsystem is described that can provide optimized amounts of excitation light within the short exposure times necessary to measure fast biological activity. The amount of light can be precisely measured to provide quantitative results. The light flux can also be precisely controlled to generate only a prescribed minimum amount of light, in order to reduce adverse lighting effects on both fluors and samples. Although the examples herein illustrate the providing of metered dosage illumination in the context of a bioanalysis system, the techniques can be similarly used to provide metered dosage illumination in the context of other types of system. In accordance with various embodiments, the technique is particularly useful in any quality-control, analysis, or assessment-based environment. Typical research and development applications can include quality control, instrument calibration, and light output standardization; while clinical and diagnostics applications can include clinical monitoring, bioassay calibration and control for diagnostics, treatment and or therapeutic evaluation.

Abstract translation: 生物分析或其他系统中计量剂量照明的系统和方法。 根据实施例，描述了可以在测量快速生物活性所需的短曝光时间内提供优化量的激发光的照明系统或子系统。 可以精确测量光量以提供定量结果。 也可以精确地控制光通量以仅产生规定的最小量的光，以便减少对荧光和样品的不利的照明效果。 虽然本文的实施例说明了在生物分析系统的背景下提供计量剂量照明，但是这些技术可以类似地用于在其他类型的系统的上下文中提供计量剂量照明。 根据各种实施例，该技术在任何基于质量控制，分析或评估的环境中特别有用。 典型的研发应用包括质量控制，仪器校准和光输出标准化; 而临床和诊断应用可以包括用于诊断，治疗和/或治疗评估的临床监测，生物测定校准和控制。