公开(公告)号：US20180073075A1

公开(公告)日：2018-03-15

申请号：US15713462

申请日：2017-09-22

Applicant: LineaGen, Inc.

Inventor： Bradley Todd Webb ,  Barbara K. Zedler ,  Edward Lenn Murrelle ,  Mark Leppert ,  Edwin J. C. G. van den Oord ,  Daniel E. Adkins ,  Willie J. McKinney

IPC: C12Q1/68 ,  G01N33/574

CPC classification number: C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172 ,  G01N33/57423 ,  G01N2800/104 ,  G01N2800/12 ,  G01N2800/122 ,  G01N2800/323 ,  G01N2800/382

Abstract: The technology provided herein relates to the SNPs identified as described herein, both singly and in combination, as well as to the use of these SNPs, and others in linkage disequilibrium with these SNPs, for diagnosis, prediction of clinical course, and/or treatment response for pulmonary disease such as COPD, development of new treatments for pulmonary disease such as COPD based upon comparison of the variant and normal versions of the gene or gene product, and development of cell-culture based and animal models for research and treatment of pulmonary disease such as COPD. The technology provided herein further relates to novel compounds, pharmaceutical compositions, and kits for use in the diagnosis, treatment, and evaluation of such disorders.