公开(公告)号：US20230184768A1

公开(公告)日：2023-06-15

申请号：US17997267

申请日：2021-04-30

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Jacob N. WOHLSTADTER ,  George SIGAL ,  Anu MATHEW ,  James WILBUR ,  Jeffery DEBAD ,  Christopher CAMPBELL ,  Hans BIEBUYCK ,  Priscilla KRAI ,  Alan KISHBAUGH ,  Leonid DZANTIEV ,  Christopher SHELBURNE ,  Pu LIU ,  Paul GOODWIN

IPC: G01N33/569 ,  G01N33/68

CPC classification number: G01N33/56983 ,  G01N33/6854 ,  G01N2333/11 ,  G01N2333/165 ,  G01N2469/20

Abstract: The invention relates to methods and kits for detecting a virus, e.g., a respiratory virus such as a coronavirus, in a biological sample. The invention also relates to methods and kits for detecting and/or quantifying biomarkers, e.g., antibody biomarkers against a viral antigen; inflammatory and/or tissue damage response biomarkers; and/or extracellular vesicles in response to a viral infection.

公开(公告)号：US20220145363A1

公开(公告)日：2022-05-12

申请号：US17453991

申请日：2021-11-08

Applicant: MESO SCALE TECHNOLOGIES, LLC. ,  The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. ,  The United States of America,as represented by the Secretary,Department of Health and Human Services

Inventor： Christopher CAMPBELL ,  Kimbra KENNEY ,  Jessica GILL

IPC: C12Q1/686 ,  C12Q1/6853 ,  G01N27/327 ,  G01N21/76

Abstract: The invention relates to methods and kits for assessing brain injury, e.g., traumatic brain injury resulting from blast exposure. The invention provides methods of quantifying the amount of phosphorylated tau or total tau in a biological sample. The invention further provides a method of determining the number of blast exposures experienced by a subject. Also provided herein are kits for detecting phosphorylated tau or total tau in a biological sample.

公开(公告)号：US20210349104A1

公开(公告)日：2021-11-11

申请号：US17246364

申请日：2021-04-30

Applicant: Meso Scale Technologies, LLC. ,  The United States of America,as represented by the Secretary,Department of Health and Human Services

Inventor： Jacob N. WOHLSTADTER ,  George SIGAL ,  Anu MATHEW ,  James WILBUR ,  Jeffery DEBAD ,  Christopher CAMPBELL ,  Hans BIEBUYCK ,  Priscilla KRAI ,  Alan KISHBAUGH ,  Leonid DZANTIEV ,  Christopher SHELBURNE ,  Pu LIU ,  Paul GOODWIN ,  Adrian MCDERMOTT ,  Sarah O'CONNELL ,  Sandeep NARPALA

IPC: G01N33/68

Abstract: The invention relates to methods and kits for detecting a virus, e.g., a respiratory virus such as a coronavirus, in a biological sample. The invention also relates to methods and kits for detecting and/or quantifying biomarkers, e.g., antibody biomarkers against a viral antigen; inflammatory and/or tissue damage response biomarkers; and/or extracellular vesicles in response to a viral infection.

公开(公告)号：US20230021837A1

公开(公告)日：2023-01-26

申请号：US17779900

申请日：2020-11-25

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Anu MATHEW ,  Mingyue WANG ,  Christopher CAMPBELL ,  Katarzyna HAYNESWORTH ,  Nikhil PADMANABHAN ,  Martin STENGELIN ,  Paridhi GUPTA ,  Rashmi SRIRAM

IPC: G01N33/564 ,  G01N33/543

Abstract: The invention relates to assay methods and kits for assessing autoimmune diseases in a human subject. In embodiments, the present disclosure provides assay methods and kits for diagnosing a subject with or predicting that a subject will develop Type 1 diabetes. In embodiments, the present disclosure provides assay methods and kits for assessing responsiveness of a subject having Type 1 diabetes to treatment with alefacept. In embodiments, the present disclosure provides assay methods and kits for diagnosing a subject with systemic lupus erythematosus. In embodiments, the present disclosure provides assay methods and kits for determining if a subject is at risk of a systemic lupus erythematosus flare. In embodiments, the present disclosure provides assay methods and kits for diagnosing a subject with celiac disease.

公开(公告)号：US20220381780A1

公开(公告)日：2022-12-01

申请号：US17749721

申请日：2022-05-20

Applicant: Meso Scale Technologies, LLC. ,  The United States of America,as represented by the Secretary,Department of Health and Human Services

Inventor： Jacob N. WOHLSTADTER ,  George SIGAL ,  James WILBUR ,  Jeffery DEBAD ,  Hans BIEBUYCK ,  Priscilla KRAI ,  Alan KISHBAUGH ,  Leonid DZANTIEV ,  Christopher SHELBURNE ,  Christopher CAMPBELL ,  Anastasia AKSYUK ,  Adrian MCDERMOTT ,  Sarah O'CONNELL ,  Sandeep NARPALA ,  Chien Li LIN

IPC: G01N33/569 ,  G01N33/543 ,  G01N33/58

Abstract: The invention relates to methods and kits for determining a SARS-CoV-2 strain in a sample. The invention further provides methods and kits for detecting a single nucleotide polymorphism (SNP) in a target nucleic acid, wherein the target nucleic acid is a SARS-CoV-2 nucleic acid. The invention further provides methods and kits for detecting one or more antibody biomarkers in a sample.