公开(公告)号：US3801580A

公开(公告)日：1974-04-02

申请号：US3801580D

申请日：1971-10-22

Applicant: MONTEDISON SPA

Inventor： MINISCI F ,  BERTINI F ,  GALLI R ,  QUILICO A

IPC: C07D213/06 ,  C07D213/127 ,  C07D213/22 ,  C07D213/68 ,  C07D213/79 ,  C07D213/84 ,  C07D215/04 ,  C07D215/18 ,  C07D217/02 ,  C07D31/20 ,  C07D33/30 ,  C07D35/22

CPC classification number: C07D213/06 ,  C07D213/22 ,  C07D213/68 ,  C07D213/79 ,  C07D213/84 ,  C07D215/04 ,  C07D215/18 ,  C07D217/02

Abstract: A PROCESS IS DISCLOSED FOR ALKYLATING PYRIDINE DERIVATIVES (INCLDING PYRIDINE) AND FOR OBTAINING ALKYL- AND CYCLOALKYL-DERIVATIVES OF PYRIDINE IN WHICH THE ALKYL OF CYCLOALKYL GROUP IS IN A 2, 4 OR 6 POSITION WITH RESPECT TO THE HETEROCYCLIC NIITROGEN ATOM, WHEREIN THE PYRIDINE DERIVATIVE IS REACTED IN AN AQUEOUS SOLUTION WITH A CARBOXYLIC ACID, R-COOH, WHEREIN R IS AN ALKYL OR A CYCLOALKYL GROUP HAVING FROM 1 TO 17 CARBON ATOMS, IN THE PRESENCE OF AN ALKALINE OR AMMONIUM PERSULPHATE AND OF CATALYTIC QUANTITIES OF AG+ IONS, AT ATMOSPHERIC PRESSURE AND AT TEMPERATURES BETWEEN 40* C. AND 100* C.

公开(公告)号：US3719685A

公开(公告)日：1973-03-06

申请号：US3719685D

申请日：1971-04-09

Applicant: MONTEDISON SPA

Inventor： MINISCI F ,  QUILICO A ,  BERTINI F ,  GALLI R

IPC: C07D213/79 ,  C07D213/81 ,  C07D213/84 ,  C07D31/36

CPC classification number: C07D213/79 ,  C07D213/81 ,  C07D213/84

Abstract: 2-R,4-Y-PYRIDINE


A PROCESS FOR ALKYLATING PYRIDINIC DERIVATIVES IS DISCLOSED, AND MORE PARTICULARLY THE ALKYLATION OF DERIVATIVES OF ISONICOTINIC ACID, IN ORDER TO OBTAIN 2-ALKYL DERIVATIVES HAVING THE FORMULA:
WHEREIN R REPRESENTS AN ALKYL GROUP HAVING FROM 1 TO 4 CARBON ATOMS AND Y REPRESENTS A HYDROGEN ATOM OR A FUNCTIONAL GROUP COOR'' (WHEREIN R'' IS AN ALKYL GROUP HAVING FROM 1 TO 4 CARBON ATOMS), CONH2 OR CN, THE PROCESS BEING CHARACTERIZED IN THAT THE PYRIDINIC DERIVATIVE IS TREATED IN AN ACID AQUEOUS SOLUTION WITH A MIXTURE PREPARED SEPARATELY FROM A DIALKYLKETONE HAVING FROM 4 TO 6 CARBON ATOMS AND FROM HYDROGEN PEROXIDE, IN THE PRESENCE OF A FERROUS SALT, UNDER ATMOSPHERIC PRESSURE AND AT A TEMPERATURE BETWEEN 0* AND 50*C.

公开(公告)号：US3781286A

公开(公告)日：1973-12-25

申请号：US3781286D

申请日：1970-11-17

Applicant: MONTEDISON SPA

Inventor： MINISCI F ,  GALLI R ,  QUILICO A

IPC: C07D213/81 ,  C07D215/48 ,  C07D215/50 ,  C07D217/26 ,  C07D235/24 ,  C07D241/24 ,  C07D241/28 ,  C07D241/44 ,  C07D277/68 ,  C07D51/76 ,  C07D51/78

CPC classification number: C07D213/81 ,  C07D215/48 ,  C07D215/50 ,  C07D217/26 ,  C07D235/24 ,  C07D241/24 ,  C07D241/44 ,  C07D277/68

Abstract: A PROCESS IS DISCLOSED FOR THE PREPARATION OF AMIDES OF NITROGEN AROMATIC HETEROCYCLIC BASES WHEREIN A HETEROAROMATIC BASE, PREFERABLY IN SALT FORM IS REACTED WITH A FORMAMIDE, HCONR2, WHEREIN R IS HYDROGEN OR AN ALKYL GROUP HAVING FROM 1 TO 5 CARBON ATOMS, PREFERABLY CH3, AND WITH A RADICAL R''O$ WHEREIN R'' IS HYDROGEN, AN ALKYL OR A CYCLOALKYL GROUP. THE SOURCE FOR THE R''O$ RADICALS IS A REDOX SYSTEM CONSISTING ESSENTIALLY OF R''OOH+FE++, WHEREIN R'' IS HYDROGEN, AN ALKYL OR A CYCLOALKYL GROUP, AT TEMPERATURES BETWEEN -10* AND 60*C., AND PREFERABLY AT TEMPERATURE BETWEEN -5* AND +35*C.