公开(公告)号：US20120041052A1

公开(公告)日：2012-02-16

申请号：US13206055

申请日：2011-08-09

Applicant: Iwan BEUVINK ,  Jonathan HALL ,  Jan WEILER ,  Christian Rene SCHNELL ,  Matthias MUELLER ,  Martina SCHINKE-BRAUN ,  Fabrizio SERLUCA

Inventor： Iwan BEUVINK ,  Jonathan HALL ,  Jan WEILER ,  Christian Rene SCHNELL ,  Matthias MUELLER ,  Martina SCHINKE-BRAUN ,  Fabrizio SERLUCA

IPC: A61K31/713 ,  C12N15/85 ,  A61P21/00 ,  C12N5/00 ,  C07H21/04 ,  A61P9/00 ,  C12N15/113 ,  C12N5/10

CPC classification number: C12N15/113 ,  C12N2310/113 ,  C12N2310/141

Abstract: The present invention relates to a novel microRNA, mir-208-2, implicated in muscular and cardiovascular disorders. The present invention also relates to oligonucleotide therapeutic agents (antisense oligonucleotides and/or double stranded oligonucleotides such as dsRNA) and their use in the treatment of muscular and cardiovascular disorders resulting from dysregulation of mir-208-2.

Abstract translation: 本发明涉及涉及肌肉和心血管疾病的新型微小RNA，mir-208-2。 本发明还涉及寡核苷酸治疗剂（反义寡核苷酸和/或双链寡核苷酸，例如dsRNA）及其在治疗由mir-208-2失调导致的肌肉和心血管疾病的用途。

公开(公告)号：US20100069193A1

公开(公告)日：2010-03-18

申请号：US12518219

申请日：2007-12-07

Applicant: Matthias MUELLER ,  Steffen MUTSCHLER

Inventor： Matthias MUELLER ,  Steffen MUTSCHLER

IPC: F16H47/04

CPC classification number: B60K6/12 ,  B60W10/02 ,  B60W10/04 ,  B60W10/30 ,  B60W20/00 ,  F16H3/72 ,  Y02T10/6208

Abstract: The invention relates to a method for controlling a drive system (1) and to a drive system (1) having a drive machine (2) which is connected to a first element (6) of an epicyclic gearing (5). The drive system (1) also comprises a shift gearing (4) which is connected to a third element (9) of the epicyclic gearing. Also provided is a hydrostatic machine (3) which is connected to a second element (7) of the epicyclic gearing (5). The hydrostatic machine (3) is set to a negligible displacement volume (VhM) A gear stage of the shift gearing (4) is engaged. The displacement volume (VhM) of the hydrostatic machine (3) is increased and the hydrostatic machine (3) charges a hydraulic accumulator (26). After moment equilibrium is reached in the epicyclic gearing (5), the displacement volume (VhM) of the hydrostatic machine (3) is supplied to the epicyclic gearing (5). In the event of synchronization of the epicyclic gearing (5), a clutch (12) for blocking the epicyclic gearing (5) is closed. The hydraulic accumulator (26) is discharged further via the hydrostatic machine (3) and adds a torque generated by the drive machine (2).

Abstract translation: 本发明涉及一种用于控制驱动系统（1）和驱动系统（1）的方法，所述驱动系统（1）具有连接到行星齿轮传动装置（5）的第一元件（6）的驱动机器（2）。 驱动系统（1）还包括连接到行星齿轮传动装置的第三元件（9）的换档齿轮（4）。 还提供了一种连接到行星齿轮传动装置（5）的第二元件（7）的静液压机（3）。 静液压机（3）设定为可忽略的排量（VhM）。变速齿轮（4）的齿轮级接合。 静液压机（3）的排量（VhM）增加，静液压机（3）对液压蓄能器（26）充电。 在行星齿轮传动装置（5）中达到力矩平衡后，静液压机（3）的排量（VhM）被提供给行星齿轮传动装置（5）。 在行星齿轮传动装置（5）的同步的情况下，用于阻挡行星齿轮传动装置（5）的离合器（12）被关闭。 液压蓄能器（26）经由静液压机（3）进一步排出，并增加由驱动机（2）产生的转矩。

公开(公告)号：US20120114744A1

公开(公告)日：2012-05-10

申请号：US13352570

申请日：2012-01-18

Applicant: Iwan BEUVINK ,  Jonathan HALL ,  Jan WEILER ,  Christian SCHNELL ,  Matthias MUELLER ,  Martina SCHINKE-BRAUN ,  Fabrizio SERLUCA

Inventor： Iwan BEUVINK ,  Jonathan HALL ,  Jan WEILER ,  Christian SCHNELL ,  Matthias MUELLER ,  Martina SCHINKE-BRAUN ,  Fabrizio SERLUCA

IPC: A61K31/713 ,  A61P9/00 ,  A61K9/127

CPC classification number: C12N15/113 ,  C12N2310/113 ,  C12N2310/141

Abstract: The present invention relates to a novel microRNA, mir-208-2, implicated in muscular and cardiovascular disorders. The present invention also relates to oligonucleotide therapeutic agents (antisense oligonucleotides and/or double stranded oligonucleotides such as dsRNA) and their use in the treatment of muscular and cardiovascular disorders resulting from dysregulation of mir-208-2.

Abstract translation: 本发明涉及涉及肌肉和心血管疾病的新型微小RNA，mir-208-2。 本发明还涉及寡核苷酸治疗剂（反义寡核苷酸和/或双链寡核苷酸，例如dsRNA）及其在治疗由mir-208-2失调导致的肌肉和心血管疾病的用途。

公开(公告)号：US20110099700A1

公开(公告)日：2011-05-05

申请号：US12940338

申请日：2010-11-05

Applicant: Christian SEIBT ,  Matthias MUELLER

Inventor： Christian SEIBT ,  Matthias MUELLER

IPC: E03D5/00

CPC classification number: E03F1/006 ,  B64D11/02

Abstract: A monitoring device and method are provided for monitoring a vacuum toilet, as well as a personal transport vehicle, in particular an aircraft, which uses a monitoring device for vacuum toilets. The monitoring device has a position detector for detecting the position of a toilet lid, a mechanical latching device and a flushing control unit. The latching device is designed to latch the toilet lid in an open position based on the weight of a person acting on a toilet seat. The flushing control unit is further designed to control the flushing operation based on the toilet lid position, and to block the flushing operation upon detection of the toilet lid in the open position. This makes it possible to improve both the comfort and hygienic conditions for the toilet user while using the vacuum toilet.

Abstract translation: 提供了一种用于监测真空马桶的监视装置和方法，以及使用用于真空马桶的监视装置的个人运输车辆，特别是飞行器。 监视装置具有用于检测马桶盖的位置的位置检测器，机械闭锁装置和冲洗控制单元。 闩锁装置被设计成基于作用在马桶座圈上的人的重量将马桶盖闩锁在打开位置。 冲洗控制单元还被设计成基于马桶盖位置来控制冲洗操作，并且在检测到马桶盖处于打开位置时阻止冲洗操作。 这使得可以在使用真空马桶时改善厕所使用者的舒适性和卫生条件。

公开(公告)号：US20100179418A1

公开(公告)日：2010-07-15

申请号：US12483342

申请日：2009-06-12

Applicant: Matthias MUELLER ,  Florian GRAS ,  Georg CHRISTIAN ,  Jörg UHDE

Inventor： Matthias MUELLER ,  Florian GRAS ,  Georg CHRISTIAN ,  Jörg UHDE

IPC: A61B5/05

CPC classification number: A61B34/20 ,  A61B17/17 ,  A61B34/10 ,  A61B2034/107 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/2074

Abstract: The invention relates to an instrument aligning method in which a medical instrument to be aligned is aligned to a target point, wherein the spatial position of the instrument to be aligned is determined and tracked by means of a medical tracking system, wherein the target point is indicated by a freely movable pointing instrument, which is likewise determined and tracked by means of the medical tracking system, and the instrument to be aligned is then aligned to the target point with the aid of a medical navigation which is associated with the tracking system.

Abstract translation: 本发明涉及一种仪器对准方法，其中待对准的医疗器械与目标点对准，其中通过医疗跟踪系统确定和跟踪要对准的仪器的空间位置，其中目标点为 由可自由移动的指示仪器指示，其同样由医疗跟踪系统确定和跟踪，然后借助与跟踪系统相关联的医疗导航将待对准的仪器与目标点对准。

公开(公告)号：US20130252183A1

公开(公告)日：2013-09-26

申请号：US13742096

申请日：2013-01-15

Applicant: Matthias MUELLER

Inventor： Matthias MUELLER

IPC: F24C3/08 ,  F24C3/12

CPC classification number: F24C3/08 ,  F23D14/065 ,  F23D14/085 ,  F23D2900/14062 ,  F24C3/12

Abstract: A gas burner has a burner base formed with inner and outer upwardly open annular base chambers each connected to a respective gas supply. An inner burner on the burner base has gas outlet orifices that create an inner flame ring. An annular outer burner on the burner base has inner gas outlet orifices on its inner annular periphery creating an intermediate flame ring and outer gas outlet orifices on its outer annular periphery creating an outer flame ring. This outer burner also has two coaxial and separate inner and outer annular gas chambers that are downwardly open toward the burner base. The outlet orifices of the intermediate flame ring open into the inner annular gas chamber while the gas outlet orifices of the outer flame ring open into the outer annular gas chamber.

Abstract translation: 气体燃烧器具有形成有内部和外部向上开放的环形基室的燃烧器基座，每个连接到相应的气体供应源。 燃烧器基座上的内部燃烧器具有产生内部火焰环的气体出口孔。 燃烧器基座上的环形外燃烧器在其内环形周边上具有内部气体出口孔，在其外环形周边上形成中间火焰环和外部气体出口孔，形成外部火焰环。 该外部燃烧器还具有朝向燃烧器基座向下开口的两个同轴且分离的内部和外部环形气体室。 中间火焰环的出口孔打开到内环形气室中，而外火焰环的气体出口孔打开到外环形气室中。