公开(公告)号：US20220326255A1

公开(公告)日：2022-10-13

申请号：US17708789

申请日：2022-03-30

Applicant: MediBeacon Inc.

Inventor： Phillip I. Tarr ,  Richard B. Dorshow

IPC: G01N33/68 ,  A61B5/00 ,  A61K31/4965 ,  G01N33/493

Abstract: The disclosure provides for methods for monitoring mucosal healing in a patient with a digestive disease, or for use in a pre-disease state, and includes intestinal as well as extra-intestinal disorders in which gut permeability is increased. The method may include establishing a baseline of the patient, treating the patient for the digestive disease or the pre-disease state, measuring gut permeability of the patient after treatment, and comparing a second total percentage of the administered dose recovered to the baseline total percentage of the administered dose recovered. Establishing the baseline may include enterally administering a first dosage of a composition comprising a fluorescent tracer, measuring a first amount of the administered dose that can be found outside the gut over a period of time, and determining a baseline total percentage of the administered dose recovered. Measuring gut permeability may include enterally administering a second dosage of the composition, measuring a second amount of the administered dose, and determining a second total percentage of the administered dose recovered.

公开(公告)号：US12048751B2

公开(公告)日：2024-07-30

申请号：US17652037

申请日：2022-02-22

Applicant: MediBeacon Inc.

Inventor： Richard B. Dorshow ,  Steven J. Hanley ,  Phillip I. Tarr

IPC: A61K49/00

CPC classification number: A61K49/0052 ,  A61K49/0021

Abstract: Compositions and methods for assessing gut function are disclosed. They are designed to provide accurate, rapid, point-of-care or in-community assessment of enteric dysfunction.

公开(公告)号：US20190142976A1

公开(公告)日：2019-05-16

申请号：US16200353

申请日：2018-11-26

Applicant: MediBeacon Inc.

Inventor： Richard B. Dorshow ,  Steven J. Hanley ,  Phillip I. Tarr

IPC: A61K49/00

Abstract: Compositions and methods for assessing gut function are disclosed. They are designed to provide accurate, rapid, point-of-care or in-community assessment of enteric dysfunction.

公开(公告)号：US11285224B2

公开(公告)日：2022-03-29

申请号：US16200353

申请日：2018-11-26

Applicant: MediBeacon Inc.

Inventor： Richard B. Dorshow ,  Steven J. Hanley ,  Phillip I. Tarr

IPC: A61K49/00

Abstract: Compositions and methods for assessing gut function are disclosed. They are designed to provide accurate, rapid, point-of-care or in-community assessment of enteric dysfunction.

公开(公告)号：US20220241438A1

公开(公告)日：2022-08-04

申请号：US17652037

申请日：2022-02-22

Applicant: MediBeacon Inc.

Inventor： Richard B. Dorshow ,  Steven J. Hanley ,  Phillip I. Tarr

IPC: A61K49/00

Abstract: Compositions and methods for assessing gut function are disclosed. They are designed to provide accurate, rapid, point-of-care or in-community assessment of enteric dysfunction.

公开(公告)号：US11077211B2

公开(公告)日：2021-08-03

申请号：US14538770

申请日：2014-11-11

Applicant: MediBeacon Inc.

Inventor： Richard B Dorshow ,  Steven J. Hanley ,  Phillip I. Tarr

IPC: A61K49/00

Abstract: Compositions and methods for assessing gut function are disclosed. They are designed to provide accurate, rapid, point-of-care or in-community assessment of enteric dysfunction.

公开(公告)号：US11285223B2

公开(公告)日：2022-03-29

申请号：US16200311

申请日：2018-11-26

Applicant: MediBeacon Inc.

Inventor： Richard B. Dorshow ,  Steven J. Hanley ,  Phillip I. Tarr

IPC: A61K49/00

Abstract: Compositions and methods for assessing gut function are disclosed. They are designed to provide accurate, rapid, point-of-care or in-community assessment of enteric dysfunction.

公开(公告)号：US20190091348A1

公开(公告)日：2019-03-28

申请号：US16200311

申请日：2018-11-26

Applicant: MediBeacon Inc.

Inventor： Richard B. Dorshow ,  Steven J. Hanley ,  Phillip I. Tarr

IPC: A61K49/00

Abstract: Compositions and methods for assessing gut function are disclosed. They are designed to provide accurate, rapid, point-of-care or in-community assessment of enteric dysfunction.