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公开(公告)号：US11737866B2
公开(公告)日：2023-08-29
申请号：US17391279
申请日：2021-08-02
Applicant: Medtronic, Inc.
Inventor： Wei Wang , Joshua Dudney , Kshitija P. Garde , Laura McKinley , Benjamin Wong
CPC classification number: A61F2/2409 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61L27/20 , A61L27/50 , A61L27/507 , A61F2/2436 , A61F2210/0061 , A61F2250/0069 , A61L2430/20 , A61L27/20 , C08L1/00
Abstract: A paravalvular leak resistant prosthetic heart valve system including a stent frame, a valve structure and a sealing mechanism. The stent frame has a surface. The valve structure is associated with the stent frame. The sealing mechanism at least partially extends over the surface of the stent frame. The sealing mechanism includes at least one semi-permeable membrane and an osmotic gradient driving material.
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公开(公告)号：US20170095594A1
公开(公告)日：2017-04-06
申请号：US15386421
申请日：2016-12-21
Applicant: Medtronic, Inc.
Inventor： Laura McKinley , Monique Poon , Will Wei Wang , Benjamin Wong
IPC: A61L27/36
CPC classification number: A61L27/3687 , A61L27/3604 , A61L27/3625 , A61L2400/02 , A61L2430/20 , A61L2430/40
Abstract: A method of reducing phospholipid concentration in biological tissue. The biological tissue is immersed in an isopropyl alcohol solution for an effective period of time. After the effective period of time, the biological tissue has a phospholipid concentration that is at least 10 percent by weight less than an initial phospholipid concentration of the biological tissue.
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公开(公告)号：US09555162B2
公开(公告)日：2017-01-31
申请号：US14187870
申请日：2014-02-24
Applicant: Medtronic, Inc.
Inventor： Laura McKinley , Monique Poon , Will Wei Wang , Benjamin Wong
CPC classification number: A61L27/3687 , A61L27/3604 , A61L27/3625 , A61L2400/02 , A61L2430/20 , A61L2430/40
Abstract: A method of reducing phospholipid concentration in biological tissue. The biological tissue is immersed in an isopropyl alcohol solution for an effective period of time. After the effective period of time, the biological tissue has a phospholipid concentration that is at least 10 percent by weight less than an initial phospholipid concentration of the biological tissue.
Abstract translation: 降低生物组织中磷脂浓度的方法。 将生物组织浸渍在异丙醇溶液中有效的一段时间。 在有效的时间段之后，生物组织的磷脂浓度比生物组织的初始磷脂浓度小至少10重量％。
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公开(公告)号：US20150305860A1
公开(公告)日：2015-10-29
申请号：US14259340
申请日：2014-04-23
Applicant: Medtronic, Inc.
Inventor： Will Wang , Joshua Dudney , Kshitija P. Garde , Laura McKinley , Benjamin Wong
IPC: A61F2/24
CPC classification number: A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2436 , A61F2210/0061 , A61F2250/0069 , A61L27/20 , A61L27/50 , A61L27/507 , A61L2430/20 , C08L1/00
Abstract: A paravalvular leak resistant prosthetic heart valve system including a stent frame, a valve structure and a sealing mechanism. The stent frame has a surface. The valve structure is associated with the stent frame. The sealing mechanism at least partially extends over the surface of the stent frame. The sealing mechanism includes at least one semi-permeable membrane and an osmotic gradient driving material.
Abstract translation: 包括支架框架，阀门结构和密封机构的瓣膜泄漏的假体心脏瓣膜系统。 支架框架具有表面。 阀结构与支架框架相关联。 密封机构至少部分地延伸到支架框架的表面上。 密封机构包括至少一个半透膜和渗透梯度驱动材料。
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公开(公告)号：US20150238658A1
公开(公告)日：2015-08-27
申请号：US14187870
申请日：2014-02-24
Applicant: Medtronic, Inc.
Inventor： Laura McKinley , Monique Poon , Will Wei Wang , Benjamin Wong
CPC classification number: A61L27/3687 , A61L27/3604 , A61L27/3625 , A61L2400/02 , A61L2430/20 , A61L2430/40
Abstract: A method of reducing phospholipid concentration in biological tissue. The biological tissue is immersed in an isopropyl alcohol solution for an effective period of time. After the effective period of time, the biological tissue has a phospholipid concentration that is at least 10 percent by weight less than an initial phospholipid concentration of the biological tissue.
Abstract translation: 降低生物组织中磷脂浓度的方法。 将生物组织浸渍在异丙醇溶液中有效的一段时间。 在有效的时间段之后，生物组织的磷脂浓度比生物组织的初始磷脂浓度小至少10重量％。
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Patent Agency Ranking
公开(公告)号：US12201515B2
公开(公告)日：2025-01-21
申请号：US18221332
申请日：2023-07-12
Applicant: Medtronic, Inc.
Inventor： Wei Wang , Joshua Dudney , Kshitija P. Garde , Laura McKinley , Benjamin Wong
Abstract: A paravalvular leak resistant prosthetic heart valve system including a stent frame, a valve structure and a sealing mechanism. The stent frame has a surface. The valve structure is associated with the stent frame. The sealing mechanism at least partially extends over the surface of the stent frame. The sealing mechanism includes at least one semi-permeable membrane and an osmotic gradient driving material.
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公开(公告)号：US10321987B2
公开(公告)日：2019-06-18
申请号：US14259340
申请日：2014-04-23
Applicant: Medtronic, Inc.
Inventor： Wei Wang , Joshua Dudney , Kshitija P. Garde , Laura McKinley , Benjamin Wong
Abstract: A paravalvular leak resistant prosthetic heart valve system including a stent frame, a valve structure and a sealing mechanism. The stent frame has a surface. The valve structure is associated with the stent frame. The sealing mechanism at least partially extends over the surface of the stent frame. The sealing mechanism includes at least one semi-permeable membrane and an osmotic gradient driving material.
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公开(公告)号：US20250120804A1
公开(公告)日：2025-04-17
申请号：US18984116
申请日：2024-12-17
Applicant: Medtronic, Inc.
Inventor： Wei Wang , Joshua Dudney , Kshitija P. Garde , Laura McKinley , Benjamin Wong
Abstract: A prosthetic heart valve includes a stent frame with a first end portion, a second end portion, and a central portion extending between the first end portion and the second end portion. The stent frame extends in a first direction of a longitudinal axis of the prosthetic heart valve from the first end portion to the second end portion. The prosthetic heart valve further includes a support arm coupled to the stent frame, a valve structure associated with the stent frame, and a seal configured to expand to a swelled orientation by fluid passing into the seal.
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公开(公告)号：US11096780B2
公开(公告)日：2021-08-24
申请号：US16407321
申请日：2019-05-09
Applicant: Medtronic, Inc.
Inventor： Wei Wang , Joshua Dudney , Kshitija P. Garde , Laura McKinley , Benjamin Wong
Abstract: A paravalvular leak resistant prosthetic heart valve system including a stent frame, a valve structure and a sealing mechanism. The stent frame has a surface. The valve structure is associated with the stent frame. The sealing mechanism at least partially extends over the surface of the stent frame. The sealing mechanism includes at least one semi-permeable membrane and an osmotic gradient driving material.
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公开(公告)号：US20190269504A1
公开(公告)日：2019-09-05
申请号：US16407321
申请日：2019-05-09
Applicant: Medtronic, Inc.
Inventor： Wei Wang , Joshua Dudney , Kshitija P. Garde , Laura McKinley , Benjamin Wong
Abstract: A paravalvular leak resistant prosthetic heart valve system including a stent frame, a valve structure and a sealing mechanism. The stent frame has a surface. The valve structure is associated with the stent frame. The sealing mechanism at least partially extends over the surface of the stent frame. The sealing mechanism includes at least one semi-permeable membrane and an osmotic gradient driving material.
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