公开(公告)号：US20090224881A1

公开(公告)日：2009-09-10

申请号：US12397388

申请日：2009-03-04

Applicant: Jeffrey David Koon ,  Michael Manion ,  Elizabeth Wentland ,  Ronni L. Emrich

Inventor： Jeffrey David Koon ,  Michael Manion ,  Elizabeth Wentland ,  Ronni L. Emrich

IPC: H04Q1/00

CPC classification number: G01W1/02

Abstract: A digital weather station for displaying weather related information. The digital weather station includes an electronic connection unit configured to receive weather data relating to a number of weather parameters, a processing unit configured to process the weather data relating to the number of weather parameters to determine a number of weather related health indicators, and a display unit configured to display the number of weather related health indicators.

Abstract translation: 用于显示天气相关信息的数字气象站。 数字气象站包括被配置为接收与多个天气参数相关的天气数据的电子连接单元，处理单元，被配置为处理与天气参数数相关的天气数据，以确定天气相关健康指示符的数量;以及 显示单元配置为显示与天气相关的健康指标数。

公开(公告)号：US20120241323A1

公开(公告)日：2012-09-27

申请号：US13146597

申请日：2011-03-24

Applicant: Michael Manion

Inventor： Michael Manion

IPC: C02F1/48 ,  C02F1/32 ,  C02F1/42

CPC classification number: C02F1/48 ,  C02F1/32 ,  C02F1/42 ,  C02F1/50 ,  C02F1/68 ,  C02F3/12 ,  C02F2103/002 ,  C02F2201/009 ,  C02F2201/4611 ,  C02F2201/4614 ,  C02F2201/46165 ,  C02F2201/46175 ,  C02F2303/04 ,  C02F2307/12 ,  Y02A20/212 ,  Y02W10/15

Abstract: Herein provided are methods, kits, systems, devices, etc. relating to the use of electrical energy for the treatment of fluids.

Abstract translation: 这里提供了与使用电能来处理流体有关的方法，试剂盒，系统，装置等。

公开(公告)号：US20060188948A1

公开(公告)日：2006-08-24

申请号：US11331652

申请日：2006-01-13

Applicant: David Hockenbery ,  Michael Manion

Inventor： David Hockenbery ,  Michael Manion

IPC: C12Q1/68 ,  G01N33/574

CPC classification number: G01N33/5011 ,  G01N2333/82 ,  G01N2510/00

Abstract: The present invention provides methods and combinations of methods for identifying agents that modulate the apoptotic state of a cell by binding to the hydrophobic groove of a Bcl-2 family member anti-apoptotic protein. In certain embodiments, the methods generally comprise the use of Bcl-2 family member proteins having one or more mutations in the hydrophobic groove that, relative to a corresponding protein lacking the mutation, affect, e.g., binding of desired agents or in vitro antimycin sensitivity without substantially altering tertiary protein structure. In these embodiments, the methods comprise the identification of agents that exhibit reduced binding affinities and/or other biological activities for the mutant proteins relative to the corresponding Bcl-2 family member lacking the mutation. In other embodiments, the methods generally comprise the detection of the ability of an agent to induce increased glucose uptake or lactate production in proportion to the level of expression of an anti-apoptotic Bcl-2 family member protein.

Abstract translation: 本发明提供了通过结合Bcl-2家族成员抗凋亡蛋白的疏水性凹槽来鉴定调节细胞凋亡状态的试剂的方法和方法的组合。 在某些实施方案中，所述方法通常包括使用在疏水凹槽中具有一个或多个突变的Bcl-2家族成员蛋白质，其相对于缺乏突变的相应蛋白质，影响所需试剂的结合或体外抗霉素敏感性 而没有显着改变三级蛋白质结构。 在这些实施方案中，所述方法包括相对于缺乏突变的相应Bcl-2家族成员，鉴定出显示降低的结合亲和力和/或突变蛋白的其它生物活性的试剂。 在其他实施方案中，所述方法通常包括与抗凋亡Bcl-2家族成员蛋白质的表达水平成比例地检测试剂诱导增加的葡萄糖摄取或乳酸生产的能力的能力。