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公开(公告)号：US4601881A
公开(公告)日：1986-07-22
申请号：US667299
申请日：1984-11-01
Applicant: Milo E. Webster
Inventor： Milo E. Webster
CPC classification number: G01N35/08
Abstract: A liquid handling system useful in apparatus for analyzing biological liquid specimens or the like includes a plurality of sample metering chambers, a distribution manifold connected between a sample inlet port and the sample metering chambers, and a corresponding plurality of auxiliary liquid metering chambers connected to corresponding auxiliary liquid reservoirs. Liquids are flowed from the sample inlet port through the distribution manifold to the sample metering chambers and from auxiliary liquid reservoirs to the auxiliary liquid metering chambers under the influence of reduced pressures which are selectively connected to the flow network through an integrated valve array and reduced pressure manifolds.
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公开(公告)号：US4858883A
公开(公告)日：1989-08-22
申请号：US281544
申请日：1988-12-08
Applicant: Milo E. Webster
Inventor： Milo E. Webster
CPC classification number: F16K7/17 , F16K11/022 , Y10T137/87885 , Y10T137/87893
Abstract: A valve is disclosed comprising a first body portion (2) having a first surface (16), a second body portion (4) having a second surface (51) facing the first surface, a flexible sheet (8) positioned between the first and second surfaces, a void (4) in the first body portion created and defined by a concave surface (46) formed in the first surface and one side (18) of the flexible sheet. There are at least two fluid passageways (20) (22) in the first body portion communicating with the void at spaced locations, at least one of the fluid passageways being a channel formed in the first surface and terminating at the void. A source of pressure and vacuum (50) (54) is provided for flexing the sheet against and away from the first body portion in order that when the flexible sheet is flexed against the first body portion, the passageways are sealed from each other, and when the flexible sheet is flexed away from the first body portion the fluid passageways are placed in communication with each other by way of the void.
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公开(公告)号：US5041181A
公开(公告)日：1991-08-20
申请号：US571937
申请日：1990-08-23
Applicant: Tom S. Brackett , Milo E. Webster
Inventor： Tom S. Brackett , Milo E. Webster
CPC classification number: B29C66/8264 , B29C65/02 , B29C66/02 , B29C66/341 , B29C66/71 , B29C66/7371 , F15C5/00 , B29C66/0344 , B29C71/00 , B29K2033/04 , B29K2995/0026 , B29L2031/7506 , Y10S264/71 , Y10T156/1064
Abstract: A method of producing a fluidic module from two or more pieces (B.sub.1 B.sub.2) of plastic material having an intermolecular bonded interface, comprises forming an interface surface (2) on each piece, forming at least one fluidic passageway (4) in at least one of the interface surfaces, assembling the pieces with the interface surfaces in contact with each other and confining them against expansion. Heat is applied to the assembled pieces to induce their expansion against total or limited confinement to cause transmigration of molecules from one interface surface to the other to bond the pieces together.
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公开(公告)号：US4283262A
公开(公告)日：1981-08-11
申请号：US165051
申请日：1980-07-01
Applicant: Alan D. Cormier , Milo E. Webster , John D. Czaban , Neil D. Silverman , Lynn W. Noble
Inventor： Alan D. Cormier , Milo E. Webster , John D. Czaban , Neil D. Silverman , Lynn W. Noble
IPC: G01N27/38 , G01N33/483 , G01N35/08 , G01N27/28
Abstract: A system for analyzing a biological fluid specimen or the like includes an analysis chamber and an electrochemical electrode measuring system connected in sensing relation to the analysis chamber. A flow network connects a sample inlet port and an auxiliary fluid reservoir to the analysis chamber. The flow network includes a sample line connected between the sample inlet port and the analysis chamber and an auxiliary manifold connected to the auxiliary fluid reservoir. A positive displacement pump is connected in the sample line between the analysis chamber and a waste outlet port. A valved T-connection is provided between the sample line and the manifold; an inlet isolation valve is in the sample flow path between the sample inlet and the valved T-connection; an analysis chamber isolation valve is in the sample flow path between the valved T-connection and the analysis chamber; and both the sample line and the manifold have a vent valve, the sample line vent valve being connected between the inlet and chamber isolation valves and the manifold vent valve being connected upstream of the auxiliary fluid reservoir. Coordinated operation of the several valves permits the pump to selectively flow fluid from the auxiliary reservoir or a sample through the analysis chamber, together with imposition of nonlaminar flow conditions by concurrent operation of the vent valves to provide effective cleaning of flow surfaces and analysis chambers.
Abstract translation: 用于分析生物流体样本等的系统包括分析室和连接到分析室的感测关系的电化学电极测量系统。 流动网络将样品入口端口和辅助流体容器连接到分析室。 流动网络包括连接在样品入口和分析室之间的样品管线和连接到辅助流体储存器的辅助歧管。 容积式泵连接在分析室和废物出口之间的样品管线中。 在样品管线和歧管之间提供带阀的T形连接件; 入口隔离阀位于样品入口与阀门T型连接件之间的样品流动路径中; 分析室隔离阀位于带阀T连接和分析室之间的样品流动路径中; 并且样品管线和歧管都具有通气阀，样品管线排气阀连接在入口和室隔离阀之间，并且歧管排放阀连接在辅助流体储存器的上游。 多个阀的协调操作允许泵选择性地将流体从辅助储存器或样品通过分析室，同时通过排气阀的并行操作来施加非层流流动条件，以提供对流动表面和分析室的有效清洁。
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5.发明授权
公开(公告)号：US5660370A
公开(公告)日：1997-08-26
申请号：US612324
申请日：1996-03-07
Applicant: Milo E. Webster
Inventor： Milo E. Webster
CPC classification number: F16K7/17 , Y10T137/87885 , Y10T137/87893
Abstract: A valve has a flexible sheet member which moves toward and away from a flat, non-flexing sheet member to cover and open two holes in the nonflexing sheet member to block or permit fluid flow between passageways in a second valve body portion member. The flexible sheet member is extendible into a recess formed in a first valve body portion member above the two holes so that fluid flows from one passageway through a chamber formed between the non-flexing sheet member surface and the faring surface of the flexible sheet member. The plunger head of a solenoid forces the flexible sheet member into contact with the non-flexing sheet member and when excited causes the plunger head to be moved out of contact with the flexible sheet member allowing the flexible sheet member to uncover the holes in the nonflexing sheet member. Vacuum is present at the valve site and draws the flexible sheet member away from the non-flexing sheet member substantially immediately as the plunger head is withdrawn from contact with the flexible sheet member. The solenoid is releasably engageable with a solenoid receiving opening in the first valve body portion at the valve site.
Abstract translation: 阀具有柔性片状构件，其朝向和远离平坦的不弯曲片状构件移动以覆盖和打开非挠曲片构件中的两个孔，以阻挡或允许流体在第二阀体部件中的通道之间流动。 柔性片材可延伸到形成在两个孔之上的第一阀体部分构件中的凹部中，使得流体从一个通道流过形成在非弯曲片构件表面和柔性片构件的制动表面之间的腔室。 螺线管的柱塞头迫使柔性片构件与非弯曲片构件接触，并且当被激励时，使柱塞头移动离开与柔性片构件的接触，允许柔性片构件露出非挠性片中的孔 片材成员。 真空存在于阀位处，并且当柱塞头从与柔性片构件的接触退出时，基本上立即将柔性片构件拉离非挠性片构件。 螺线管可释放地与阀位处的第一阀体部分中的螺线管接收开口接合。
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Patent Agency Ranking
公开(公告)号：US4304257A
公开(公告)日：1981-12-08
申请号：US165103
申请日：1980-07-01
Applicant: Milo E. Webster
Inventor： Milo E. Webster
CPC classification number: G01N35/1097 , B01J4/02 , F16K11/022 , Y10T137/8359 , Y10T137/87249 , Y10T137/87885
Abstract: A valve that is particularly useful in biological fluid handling systems includes a body member that has a firm and stable support surface and a flexible sheet member that has a surface for conforming and mating engagement with the surface of the valve body member. A land portion in the surface of one of the valve members separates two fluid flow channels in that member. An actuator is arranged to flex the sheet member between a first position in which the surface of the sheet member is in mating and sealing engagement with the surface of the body member to sealing block flow between the two channels, and a second position in which the sheet surface is spaced from the first position to allow fluid flow across the land surface between the two flow channels.
Abstract translation: 在生物流体处理系统中特别有用的阀包括具有坚固且稳定的支撑表面的主体构件和具有用于与阀体构件的表面一致并配合接合的表面的柔性片构件。 一个阀构件的表面中的陆部分离开该构件中的两个流体流动通道。 致动器被布置成使片材在第一位置和第二位置之间弯曲，在第一位置和第二位置之间，第一位置与第二位置之间，在第一位置，片材构件的表面与主体构件的表面密封接合， 片材表面与第一位置间隔开，以允许流体流过两个流动通道之间的平台表面。
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公开(公告)号：US4282182A
公开(公告)日：1981-08-04
申请号：US142463
申请日：1980-04-20
Applicant: Milo E. Webster
Inventor： Milo E. Webster
CPC classification number: G01N1/10 , G01N1/2226 , G01N1/2202 , G01N1/24 , G01N2001/2223
Abstract: Apparatus for analyzing the contents of a sealed package includes a package alignment assembly, and a probe assembly that has a puncturing tip. The package alignment assembly includes a positioning support surface in alignment with the puncturing tip and supplemental resiliently supported structure spaced from the support surface for aligning the package to be analyzed with the probe assembly. A flow path extends from the puncturing tip to an analysis unit for withdrawing and analyzing a sample of the contents of the package.
Abstract translation: 用于分析密封包装的内容物的装置包括包装对准组件和具有穿刺尖端的探针组件。 包装对准组件包括与穿刺尖端对准的定位支撑表面和与支撑表面间隔开的补充弹性支撑结构，用于使待分析的包装与探针组件对准。 流动路径从穿刺尖端延伸到分析单元，用于抽出和分析包装内容物的样本。
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公开(公告)号：US4999069A
公开(公告)日：1991-03-12
申请号：US360267
申请日：1989-06-02
Applicant: Tom S. Brackett , Milo E. Webster
Inventor： Tom S. Brackett , Milo E. Webster
CPC classification number: B29C66/54 , B29C65/006 , B29C65/02 , B29C66/02 , B29C66/324 , B29C66/71 , B29C66/7371 , B29C66/8264 , B29C66/9141 , B29C66/91411 , B29C66/91445 , B29C66/919 , F15C5/00 , B29C66/02245 , B29C71/00 , B29K2033/00 , B29K2033/04 , B29K2995/0026 , B29L2031/7506 , Y10S264/71 , Y10T156/1064
Abstract: A method of producing a fluidic module from two or more pieces (B.sub.1 B.sub.2) of plastic material having an intermolecular bonded interface, comprises forming an interface surface (2) on each piece, forming at least one fluidic passageway (4) in at least one of the interface surfaces, assembling the pieces with the interface surfaces in contact with each other and confining them against expansion. Heat is applied to the assembled pieces to induce their expansion against total or limited confinement to cause transmigration of molecules from one interface surface to the other to bond the pieces together.
Abstract translation: 一种由具有分子间键合界面的塑料材料的两个或更多个片（B1 B2）生产流体模块的方法，包括在每个部件上形成界面（2），在至少一个流体通道（4）中形成至少一个流体通道 的接口表面，将这些件与接口表面相互接触并将其限制在膨胀之中。 将热量施加到组装的片上以引起其全面或有限限制的膨胀，从而使分子从一个界面表面向另一个界面表面转移到另一个界面。
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公开(公告)号：US4859422A
公开(公告)日：1989-08-22
申请号：US75052
申请日：1987-07-17
Applicant: Humayun Qureshi , Stanley M. Liffmann , Milo E. Webster , Theodore S. Geiselman
Inventor： Humayun Qureshi , Stanley M. Liffmann , Milo E. Webster , Theodore S. Geiselman
CPC classification number: G01N35/085 , G01N1/14 , G01N2001/382 , G01N2035/00237 , G01N35/1097 , Y10T436/117497
Abstract: An analysis system includes sample insertion module structure with structure defining a reduced pressure reservoir, structure defining a sample region, and structure defining a reagent circuit that includes metering chamber structure in series with the reagent circuit. First transfer valve structure is arranged to couple the sample region to the reagent circuit on one side of the metering chamber structure, and second transfer valve structure is arranged to couple the reagent circuit to the reduced pressure reservoir structure on the side of the metering chamber structure remote from the first transfer valve structure for inserting an intact metered quantity of sample liquid into a reagent stream.
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公开(公告)号：US4852851A
公开(公告)日：1989-08-01
申请号：US131751
申请日：1987-12-11
Applicant: Milo E. Webster
Inventor： Milo E. Webster
CPC classification number: F16K7/17 , F16K11/022 , Y10T137/87249 , Y10T137/87885
Abstract: A valve is disclosed comprising a first body portion (2) having a first surface (16), a second body portion (4) having a second surface (51) facing the first surface, a flexible sheet (8) positioned between the first and second surfaces, a void (4) in the first body portion created and defined by a concave surface (46) formed in the first surface and one side (18) of the flexible sheet. There are at least two fluid passageways (20) (22) in the first body portion communicating with the void at spaced locations, at least one of the fluid passageways being a channel formed in the first surface and terminating at the void. A source of pressure and vacuum (50) (54) is provided for flexing the sheet against and away from the first body portion in order that when the flexible sheet is flexed against the first body portion, the passageways are sealed from each other, and when the flexible sheet is flexed away from the first body portion the fluid passageways are placed in communication with each other by way of the void.
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