公开(公告)号：US20180224378A1

公开(公告)日：2018-08-09

申请号：US15751060

申请日：2016-08-19

Applicant: Molecular Vision Limited ,  Cambridge Display Technology Limited

Inventor： Christopher John Kay ,  Chris Hand ,  Oliver Hofmann ,  Gihan Ryu ,  Miguel Ramon ,  llaria Grizzi

IPC: G01N21/77 ,  B01L3/00 ,  G01N33/558 ,  G01N33/543 ,  H01L51/00 ,  G01N33/58 ,  H01L27/28

CPC classification number: G01N21/77 ,  B01L3/5023 ,  B01L2300/0645 ,  B01L2300/069 ,  B01L2300/12 ,  B01L2400/0406 ,  G01N21/8483 ,  G01N33/54386 ,  G01N33/558 ,  G01N33/582 ,  G01N2021/7783 ,  G01N2021/8488 ,  H01L27/288 ,  H01L51/0036 ,  H01L51/0046 ,  H01L51/0085

Abstract: An improved optical detection unit for an assay device, such as a lateral flow device, for the quantitative determination of the concentration of an analyte in a liquid sample, and an assay device comprising the same. The detection unit comprises an organic light emitting diode (OLED) emitter that has an emission spectrum E within the wavelength range from λ1 to λ2, and an organic photodiode detector (OPD) that has a light detection spectrum S within the wavelength range from λ1 to λ2. The detection unit has a test region that comprises a light absorbing component that has an absorbance spectrum A within the wavelength range from λ1 to λ2. The test region is positioned adjacent to the emitter and the detector to form an optical pathway from the light emitting diode to the photodiode through at least a portion of the test region. Formula M defines a relationship between E, S and A, and M is less than about 0.4.

公开(公告)号：US20190033223A1

公开(公告)日：2019-01-31

申请号：US15752706

申请日：2016-08-19

Applicant: Molecular Vision Limited ,  Cambridge Display Technology Limited

Inventor： Chris Hand ,  Oliver Hofmann ,  Gihan Ryu ,  Miguel Ramon ,  Philip Benzie ,  Christopher John Kay

IPC: G01N21/84 ,  B01L3/00 ,  G01N33/558 ,  G01N21/64

Abstract: An assay device for the quantitative determination of the concentration of at least one analyte in a liquid sample. The device comprises a lateral flow membrane (46) comprising a plurality of test regions (41A, 41B) and formed from a light transmissive material, a plurality (44A, 44B) of planar organic light emitting diode (OLED) emitters comprising an emission layer of an organic electroluminescent material, and a plurality (49A, 49B) of planar organic photodetectors (OPDs) comprising an absorption layer of an organic photovoltaic material. Each test region comprises an immobilised component for retaining analyte tagging particles. Each test region is aligned with the emission layer of one emitter and the absorption layer of one photodetector. The aligned emitter, photodetector, and test region form a group such that the emitter is capable of illuminating the test region and the photodetector is capable of detecting light from the test region. For each group, under conditions where the test region is wet and devoid of tagging particles the energised photodetector photocurrent that is produced is denoted i1, when the group emitter is the only emitter that is energised, and T2 when the emitter of another group is additionally energised. Cross-talk (C), is then represented by the black arrows, and is defined according to the equation: C=20 log10 (i1/(i2−i1)) C is arranged to be greater than about 20 dB for at least one group of the device.

公开(公告)号：US20180260775A1

公开(公告)日：2018-09-13

申请号：US15751065

申请日：2016-08-19

Applicant: Molecular Vision Limited

Inventor： Chris Hand ,  Oliver Hofmann ,  Gihan Ryu ,  Miguel Ramon ,  Neeraj Adsul

IPC: G06Q10/08

CPC classification number: G06Q10/0832 ,  G01N21/8483 ,  G01N2021/8488

Abstract: A computer system and method is provided to filter clearance sensor data output by a sensor system during a load/offload procedure of a first object relative to a second object. A processing device of the computer system is configured to access hard threshold data, unique threshold data, and sensor data output by the sensor system sensing aspects of the load/offload procedure. The processing device is further configured to determine whether the sensor data exceeds the unique threshold, determine whether the sensor data that is determined to exceed the unique threshold is voidable data related to a noncritical event, and generate filtered sensor data that includes modifications to the voidable data.

公开(公告)号：US20180231464A1

公开(公告)日：2018-08-16

申请号：US15751074

申请日：2016-08-19

Applicant: Molecular Vision Limited

Inventor： Chris Hand ,  Oliver Hofmann ,  Gihan Ryu ,  Miguel Ramon ,  Dene Baldwin

IPC: G01N21/64 ,  G01N21/84 ,  G01N33/558 ,  G01N21/78

CPC classification number: G01N21/645 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/558 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2201/0628

Abstract: An assay device for the quantitative determination of the concentration of at least one analyte in a liquid sample comprises a planar emitter (2), a planar detector (3), a lateral flow membrane (4) interposed between the emitter (2) and the detector (3), a conjugate pad (5) in fluid communication with a proximal end of the lateral flow membrane (4), the conjugate pad (5) comprising optically detectable tagging particles bound to a first assay component, a sample pad (6) in fluid communication with the conjugate pad (5) and arranged to receive the liquid sample, and a wicking pad (7) in fluid communication with a distal end of the lateral flow membrane (4). The lateral flow membrane (4) is formed from a light transmissive material and is capable of transporting fluid from the conjugate pad (5) to the wicking pad (7) by capillary action. The lateral flow membrane (4) comprises at least one test region (8, 12) comprising an immobilised second assay component for retaining the tagging particles in the test region (8, 12) in dependence on the binding between the analyte, the first assay component and the second assay component in order to generate a concentration of tagging particles in the test region (8, 12) that is indicative of the concentration of the analyte in the liquid sample. The emitter (2) comprises an emission layer (9, 16) of an organic electroluminescent material and the emission layer (9, 16) is aligned with the test region (8, 12) of the lateral flow membrane 4, whereby the emitter (2) is capable of illuminating the test region (8, 12). The detector (3) comprises an absorption layer (10, 15) of an organic photovoltaic material and the absorption layer (10, 15) is aligned with the test region (8, 12) of the lateral flow membrane 4, whereby the detector (3) is capable of detecting light from the test region (8, 12).

公开(公告)号：US20170010261A1

公开(公告)日：2017-01-12

申请号：US15115341

申请日：2015-02-13

Applicant: MOLECULAR VISION LIMITED

Inventor： Christopher Hand ,  Oliver Hofmann ,  Gihan Ryu ,  Miguel Ramon Lorente de No

IPC: G01N33/543

CPC classification number: G01N33/54386

Abstract: An assay device for the quantitative determination of the concentration of at least one analyte in a liquid sample comprises a planar emitter 2, a planar detector 3, a lateral flow membrane 4 interposed between the emitter 2 and the detector 3, a conjugate pad 5 in fluid communication with a proximal end of the lateral flow membrane 4, the conjugate pad 5 comprising optically detectable tagging particles bound to a first assay component, a sample pad 6 in fluid communication with the conjugate pad 5 and arranged to receive the liquid sample, and a wicking pad 7 in fluid communication with a distal end of the lateral flow membrane 4. The lateral flow membrane 4 is formed from a light transmissive material and is capable of transporting fluid from the conjugate pad 5 to the wicking pad 7 by capillary action. The lateral flow membrane 4 comprises at least one test region 8,12 comprising an immobilised second assay component for retaining the tagging particles in the test region 8,12 in dependence on the binding between the analyte, the first assay component and the second assay component in order to generate a concentration of tagging particles in the test region 8,12 that is indicative of the concentration of the analyte in the liquid sample. The emitter 2 comprises an emission layer 9,16 of an organic electroluminescent material and the emission layer 9,16 is aligned with the test region 8,12 of the lateral flow membrane 4, whereby the emitter 2 is capable of illuminating the test region 8,12. The detector 3 comprises an absorption layer 10,15 of an organic photovoltaic material and the absorption layer 10,15 is aligned with the test region 8,12 of the lateral flow membrane 4, whereby the detector 3 is capable of detecting light from the test region 8,12.

Abstract translation: 用于定量测定液体样品中至少一种分析物的浓度的测定装置包括平面发射体2，平面检测器3，插入在发射体2和检测器3之间的侧向流动膜4， 与横向流动膜4的近端流体连通，共轭垫5包括结合到第一测定组分的可光学检测的标记颗粒，与缀合物垫5流体连通并被布置成接收液体样品的样品垫6，以及 与侧流膜4的远端流体连通的芯吸垫7.侧流膜4由透光材料形成，并且能够通过毛细管作用将流体从共轭垫5输送到芯吸垫7。 侧流膜4包括至少一个测试区域8,12，其包含固定的第二测定组件，用于根据分析物，第一测定组分和第二测定组分之间的结合将标记颗粒保留在测试区域8,12中 以便产生指示液体样品中分析物浓度的测试区域8,12中的标记颗粒的浓度。 发射器2包括有机电致发光材料的发射层9,16，并且发射层9,16与横向流动膜4的测试区域8,12对准，由此发射体2能够照射测试区域8 ，12。 检测器3包括有机光伏材料的吸收层10,15，并且吸收层10,15与侧流膜4的测试区域8,12对准，由此检测器3能够检测来自测试的光 区域8,12。