公开(公告)号：US20240376160A1

公开(公告)日：2024-11-14

申请号：US18255368

申请日：2022-08-30

Applicant: NANJING TECH UNIVERSITY

Inventor： Ling JIANG ,  Yao CHEN ,  Yujin CHEN ,  Liying ZHU ,  Wei LIU

IPC: C07K14/315 ,  C12N15/70 ,  C12R1/19

Abstract: The invention relates to a molecular peptide mutant with a high ester bond formation efficiency, the amino acid sequence of which is as shown in SEQ ID NO: 1. The invention introduces mutations at three sites on the basis of not affecting the spatial structure of Catcher, and through three mutations, obtains the Catcher mutant EBCatcher, which significantly improves the stability of the Catcher in water solution and can improve the binding efficiency to EBTag.