公开(公告)号：US20200075134A1

公开(公告)日：2020-03-05

申请号：US16463867

申请日：2017-11-21

Applicant: National Institute for Materials Science

Inventor： Kota Shiba ,  Ryo Tamura ,  Gaku Imamura ,  Genki Yoshikawa

IPC: G16C20/70 ,  G01N29/02 ,  G01N19/00

Abstract: The present invention provides a method and a device for estimating a value to be estimated associated with a specimen, by performing machine learning of a relationship between a value of an estimation object and an output corresponding thereto, based on an output from a chemical sensor with regard to a plurality of specimens for which specific values to be estimated are known, and using the result of the mechanical learning to estimate a specific value to be estimated on the basis of an output from the chemical sensor with regard to a given unknown specimen.

公开(公告)号：US12007405B2

公开(公告)日：2024-06-11

申请号：US17055687

申请日：2019-06-04

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE

Inventor： Kosuke Minami ,  Genki Yoshikawa ,  Gaku Imamura ,  Kota Shiba

IPC: G01N5/02 ,  G06N5/04 ,  G06N20/00

CPC classification number: G01N5/02 ,  G06N5/04 ,  G06N20/00

Abstract: Provided is a novel material analysis technique using a chemical sensor. By reversing the conventional approach, a material to be measured is provided as a receptor of the chemical sensor, and a response signal of the chemical sensor obtained by supplying a known gas or the like to the chemical sensor is obtained. From the response signal, it is possible to identify and distinguish the receptor material, and to obtain its composition and the like. By analyzing the response signal by means of a statistical or machine learning technique such as principal component analysis, linear discriminant analysis, or a support vector machine, the above-mentioned identification and the like can be performed with high accuracy.

公开(公告)号：US11774346B2

公开(公告)日：2023-10-03

申请号：US17057747

申请日：2019-06-04

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE

Inventor： Kosuke Minami ,  Gaku Imamura ,  Kota Shiba ,  Genki Yoshikawa

IPC: G01N19/00 ,  G01N5/02

CPC classification number: G01N19/00 ,  G01N5/02

Abstract: In an analysis of a fluid component using a nanomechanical sensor covered with a receptor, the same receptor is caused to express different response characteristics. In a measuring system of analyzing a response when a sample gas and a purge gas are supplied to a nanomechanical sensor while switching the sample gas and the purge gas, a gas (external gas) different from both gases is mixed into a gas channel and supplied to the sensor for measurement. Since a response characteristic of a receptor is modulated by mixing of the external gas, the object described above is achieved.

公开(公告)号：US12130270B2

公开(公告)日：2024-10-29

申请号：US17619024

申请日：2020-05-08

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE

Inventor： Gaku Imamura ,  Kosuke Minami ,  Kota Shiba ,  Genki Yoshikawa

IPC: G01N33/00 ,  C08F222/06 ,  G01L1/18 ,  G01N5/02 ,  G01N29/02

CPC classification number: G01N33/0054 ,  C08F222/06 ,  G01L1/18 ,  G01N5/02 ,  G01N29/022 ,  G01N2291/0256

Abstract: An object of the present invention is to detect ammonia with high sensitivity and high selectivity using a nanomechanical sensor with a structure that is as simple as possible. A method for detecting ammonia according to an embodiment of the present invention comprises supplying a sample gas possibly containing ammonia to a nanomechanical sensor that detects a stress or a displacement using poly(methyl vinyl ether-alt-maleic anhydride) as a material of a receptor layer, and detecting presence or absence of ammonia or a content of ammonia in the sample gas based on an output signal from the nanomechanical sensor, in which the sample gas is a humidified sample gas with controlled relative humidity.

公开(公告)号：US10564082B2

公开(公告)日：2020-02-18

申请号：US15543298

申请日：2015-08-31

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE

Inventor： Kota Shiba ,  Genki Yoshikawa ,  Yusuke Yamauchi ,  Norihiro Suzuki ,  Gaku Imamura ,  Kosuke Minami ,  Hamish Hei-Man Yeung

IPC: G01N5/00 ,  G01N5/02 ,  G01G3/13 ,  G01N29/02 ,  G01N29/036 ,  G01N21/49 ,  G01N27/22 ,  B82Y15/00

Abstract: According to improvement of the receptor layer of various sensors of the type for detecting physical parameters (for example, a surface stress sensor, QCM, and SPR), all of high sensitivity, selectivity, and durability are achieved simultaneously. A porous material or a particulate material, e.g., nanoparticles, is used in place of a uniform membrane which has been conventionally used as a receptor layer. Accordingly, the sensitivity can be controlled by changing the membrane thickness of the receptor layer, the selectivity can be controlled by changing a surface modifying group to be fixed on the porous material or particulate material, and the durability can be controlled by changing the composition and surface properties of the porous material or particulate material.

公开(公告)号：US10458939B2

公开(公告)日：2019-10-29

申请号：US15552949

申请日：2016-02-25

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE

Inventor： Kota Shiba ,  Genki Yoshikawa ,  Gaku Imamura

IPC: G01N27/12 ,  G01N5/02 ,  G01N29/02 ,  G01N29/036 ,  G01N3/00 ,  G01N21/00 ,  B82Y15/00 ,  G01N9/00 ,  G01N11/16

Abstract: As a receptor layer, a film of a composite material of a base material such as a polymer and particles that adsorb an analyte is used. When the present invention is applied to a surface stress sensor or the like, the Young's modulus of the receptor layer, which significantly affects detection sensitivity, can be preset with a high degree of freedom, by independently selecting particles that adsorb a desired analyte and a base material that disperses said particles therein.

公开(公告)号：US12100488B2

公开(公告)日：2024-09-24

申请号：US16463867

申请日：2017-11-21

Applicant: National Institute for Materials Science

Inventor： Kota Shiba ,  Ryo Tamura ,  Gaku Imamura ,  Genki Yoshikawa

IPC: G16C20/70 ,  G01N1/00 ,  G01N1/10 ,  G01N19/00 ,  G01N29/02 ,  G06N20/00 ,  G16C20/20 ,  G16C20/50 ,  G16C20/80 ,  G16C60/00

CPC classification number: G16C20/70 ,  G01N1/00 ,  G01N19/00 ,  G01N29/022 ,  G06N20/00 ,  G16C20/20 ,  G16C20/50 ,  G16C20/80 ,  G01N2001/1087 ,  G01N2001/1093 ,  G16C60/00

Abstract: The present invention provides a method and a device for estimating a value to be estimated associated with a specimen, by performing machine learning of a relationship between a value of an estimation object and an output corresponding thereto, based on an output from a chemical sensor with regard to a plurality of specimens for which specific values to be estimated are known, and using the result of the mechanical learning to estimate a specific value to be estimated on the basis of an output from the chemical sensor with regard to a given unknown specimen.

公开(公告)号：US11796408B2

公开(公告)日：2023-10-24

申请号：US17267094

申请日：2019-08-28

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE

Inventor： Genki Yoshikawa ,  Takahiro Nemoto ,  Makito Nakatsu ,  Naoto Takeda ,  Kota Shiba ,  Kosuke Minami

IPC: G01L1/00 ,  G01L1/26 ,  B08B7/00 ,  G01L1/22 ,  H01L29/84

CPC classification number: G01L1/26 ,  B08B7/005 ,  B08B7/0071 ,  G01L1/2268 ,  H01L29/84

Abstract: A method for cleaning a receptor layer of a surface stress sensor according to an embodiment of the present invention includes, in a surface stress sensor that detects a change in surface stress of a thin film, the change being caused by a receptor layer disposed on a surface of the thin film, causing at least a part of a surface region of the thin film to generate heat or supplying heat to the receptor layer from the outside of the surface stress sensor. This makes it possible to easily perform efficient cleaning of a surface stress sensor such as a sensor that performs detection using a piezoresistor while avoiding structural complications as much as possible.

公开(公告)号：US11215585B2

公开(公告)日：2022-01-04

申请号：US16613161

申请日：2018-05-21

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE

Inventor： Kota Shiba ,  Kosuke Minami ,  Genki Yoshikawa

IPC: G01N29/02

Abstract: The present invention provides a nanomechanical sensor in which a negative influence of water in a sample on measurement is suppressed. In an embodiment of the present invention, as a receptor material of the nanomechanical sensor, a low-hygroscopic material such as polysulfone, polycaprolactone, poly(vinylidene fluoride), or poly(4-methylstyrene) is used. According to this embodiment, a negative influence, such as saturation of a receptor layer by water in the sample, or masking of an output signal based on trace components by an output signal based on water contained in the sample in a large amount, can be suppressed.

公开(公告)号：US10444133B2

公开(公告)日：2019-10-15

申请号：US15555198

申请日：2016-03-04

Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE

Inventor： Genki Yoshikawa ,  Kota Shiba

IPC: G01N9/00 ,  G01N5/02 ,  G01N29/02 ,  G01N29/36 ,  G01N11/00

Abstract: A sample in a gas state to be measured is forced to impinge on a structure in which a change in a characteristic including a mechanical deformation, an optical change, an electric change and a magnetic change is exerted due to the impingement of a gaseous sample, a gasified liquid sample or solid sample to cause at least one of changes in characteristics including a mechanical deformation, an optical change, an electric change and a magnetic change; and the molecular weight of the sample in a gas state is obtained.