公开(公告)号：US20240189505A1

公开(公告)日：2024-06-13

申请号：US18287684

申请日：2022-04-21

Applicant: NORTHWESTERN UNIVERSITY ,  WILLIAM MARSH RICE UNIVERSITY

Inventor： Jonathan Rivnay ,  Omid Veiseh ,  Jacob Robinson

IPC: A61M5/142 ,  A61M5/172 ,  G16H20/17

CPC classification number: A61M5/14276 ,  A61M5/1723 ,  G16H20/17 ,  A61M2205/3306

Abstract: A bioelectronic wearable device includes engineered cells and an electronically controlled stimulator that regulates a quantity and timing of therapeutic agent produced by the engineered cells.

公开(公告)号：US20240315629A1

公开(公告)日：2024-09-26

申请号：US18613535

申请日：2024-03-22

Applicant: NORTHWESTERN UNIVERSITY

Inventor： Jonathan Rivnay ,  Joshua Tropp

IPC: A61B5/266 ,  A61B5/268 ,  C08G61/12 ,  C08L5/04 ,  C08L25/18 ,  C08L65/00

CPC classification number: A61B5/266 ,  A61B5/268 ,  C08G61/126 ,  C08L5/04 ,  C08L25/18 ,  C08L65/00 ,  C08G2261/3223 ,  C08L2201/06 ,  C08L2203/02 ,  C08L2203/20

Abstract: The invention in one aspect relates to a conductive nanomaterial comprising acid-crystalized poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS) nanoparticles (ncrys-PEDOTX) with intrinsic dispersibility.

公开(公告)号：US20240254507A1

公开(公告)日：2024-08-01

申请号：US18287709

申请日：2022-04-21

Applicant: NORTHWESTERN UNIVERSITY ,  WILLIAM MARSH RICE UNIVERSITY

Inventor： Omid Veiseh ,  Jacob Robinson ,  Jonathan Rivnay ,  Isaac Hilton ,  Samantha T. Fleury ,  Matthew C. Parker ,  Jacob H. Goell ,  Jing Li ,  Kaiyuan Wang

IPC: C12N15/85 ,  C07K14/435 ,  C12N9/22 ,  C12N9/50

CPC classification number: C12N15/85 ,  C07K14/435 ,  C12N9/22 ,  C12N9/50 ,  C12Y304/22062 ,  C12N2830/001

Abstract: An engineered cell expressing a therapeutic agent and a reporter agent, the engineered cell comprising a first transgene containing a light sensing DNA sequence encoding a light sensing protein, and a second transgene containing a calcium activated promoter, a therapeutic agent DNA encoding a therapeutic agent, and a reporter agent DNA encoding a reporter agent.

公开(公告)号：US20240207508A1

公开(公告)日：2024-06-27

申请号：US18287671

申请日：2022-04-21

Applicant: NORTHWESTERN UNIVERSITY ,  WILLIAM MARSH RICE UNIVERSITY

Inventor： Jonathan Rivnay ,  Omid Veiseh ,  Jacob Robinson ,  Samantha T. Fleury ,  Matthew C. Parker ,  Fatima T. Alrashdan

IPC: A61M5/142 ,  A61M5/172 ,  G16H40/67

CPC classification number: A61M5/14276 ,  A61M5/1723 ,  G16H40/67 ,  A61M2205/3306

Abstract: A bioelectronic implantable device includes engineered cells and an electronically controlled stimulator that regulates a quantity and timing of therapeutic agent produced by the engineered cells.

公开(公告)号：US20210324327A1

公开(公告)日：2021-10-21

申请号：US17230335

申请日：2021-04-14

Applicant: Northwestern University

Inventor： Jonathan Rivnay ,  Anthony J. Petty ,  Erin Hsu

IPC: C12N5/00 ,  C08G61/12

Abstract: Conjugated, electrically conducting polymers (CPs) with the ability to covalently graft onto collagen and collagenic materials are provided. Also provided are methods of functionalizing biological tissues and other biological substrates with the CPs, and methods of using the functionalized biological substrates as cell and tissue growth scaffolds that harness the passive therapeutic benefits of CPs and use the enhanced conductivity provided by the scaffolds to stimulate cell growth and proliferation through the bulk of the biological substrate.

公开(公告)号：US20210322648A1

公开(公告)日：2021-10-21

申请号：US17230195

申请日：2021-04-14

Applicant: Northwestern University

Inventor： Jonathan Rivnay ,  Anthony J. Petty ,  Cheng Sun ,  Henry Oliver T. Ware

IPC: A61L27/52 ,  A61L27/44 ,  C08G61/12 ,  A61L27/56 ,  C08F20/20 ,  A61L27/36

Abstract: Biocompatible polymer hydrogel composite structures, methods of making the composite structures, and methods of using the composite structures as scaffolds for biological tissue growth and regeneration are provided. The methods for making the composite structures start with a porous high resolution three-dimensional hydrogel scaffold in which polymer precursors are infused and then polymerized in situ to form a water-soluble, electrically conducting polymer that is bonded to and/or entrapped within the hydrogel.

公开(公告)号：US20250063880A1

公开(公告)日：2025-02-20

申请号：US18802775

申请日：2024-08-13

Applicant: Northwestern University

Inventor： Jonathan Rivnay ,  Zachary Alexander Laswick ,  Abhijith Surendran ,  Giovanni Maria Matrone ,  Xudong Ji

IPC: H10K10/46 ,  H10K19/10 ,  H10K85/10

Abstract: Organic electrochemical transistors (OECTs) that include a conducting channel composed of a bilayer of a p-type organic mixed ionic and electronic conductor adjacent to an n-type organic mixed ionic and electronic conductor are provided. The bilayer channel of the OECTs exhibits anti-ambipolar (OFF-ON-OFF) switching upon the application of a gate voltage, whereby a current flows through the channel when both layers of the bilayer are in an “ON” (conducting) state, but not when either or both layers are in an “OFF” (non-conducting) state.

公开(公告)号：US20230094869A1

公开(公告)日：2023-03-30

申请号：US17907852

申请日：2021-03-05

Applicant: Northwestern University

Inventor： Jonathan Rivnay ,  Reem B. Rashid ,  Robert J. Ciechowski

IPC: H10K10/46 ,  G01N27/414

Abstract: Cofacial vertical organic electrochemical transistor (vOECT) pairs, electronic circuits into which the vOECT pairs are integrated, and methods for fabricating the vOECT pairs are provided. The vOECTs pairs are formed from a vertically stacked structure that includes a first layer of an electrically conducting material, a first layer of an electrically insulating material, and a second layer of an electrically conducting material. The vOECTs of the pairs are formed on opposing sidewalls of a trench formed in the stacked structure.