公开(公告)号：US20150182137A1

公开(公告)日：2015-07-02

申请号：US14510848

申请日：2014-10-09

Applicant: NOVADAQ TECHNOLOGIES INC.

Inventor： Robert W. FLOWER ,  Robert Anthony Stead ,  Arthur E. Bailey

IPC: A61B5/0275 ,  A61B5/00

CPC classification number: A61B5/0275 ,  A61B5/0071 ,  A61B5/0295 ,  A61B5/6826

Abstract: A method and an apparatus for measuring a time-varying change in an amount of blood in a tissue include exciting a fluorescence agent in the blood, acquiring a time-varying light intensity signal during a pulsatile flow of the blood through the tissue volume, the pulsatile flow having a systolic and a diastolic phase resembling a conventional photoplethysmogram, and processing the acquired signal by applying a modified Beer-Lambert law to obtain the measurement of the time-varying change in the amount of blood in the tissue volume. The instantaneous molar concentration of the fluorescence agent is determined by utilizing a concentration-mediated change in a fluorescence emission spectrum of the fluorescence agent.

Abstract translation: 用于测量组织中血液的时变变化的方法和装置包括激发血液中的荧光剂，在通过组织体积的血液的脉动流动期间获取时变光强度信号， 具有类似于常规光谱体积图的收缩期和舒张期的脉动流，并且通过应用修改的Beer-Lambert定律来处理所获取的信号，以获得组织体积中血液量的时变变化的测量。 通过利用荧光剂的荧光发射光谱中的浓度介导的变化来确定荧光剂的瞬时摩尔浓度。