公开(公告)号：US09295392B2

公开(公告)日：2016-03-29

申请号：US13625867

申请日：2012-09-24

Applicant: NOVADAQ TECHNOLOGIES INC.

Inventor： Alexandre Douplik ,  Desmond C. Adler ,  Brian C. Wilson ,  Norman Marcon

IPC: A61B6/00 ,  A61B5/00 ,  A61B1/04

CPC classification number: A61B5/0075 ,  A61B1/043 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/4233

Abstract: A method is described for computing a statistically significant difference between dysplasia and Barrett's esophagus (both with and without inflammatory component) using a discriminate function with diffuse reflectance measurements performed at a minimum of four different wavelengths of 485, 513, 598, and 629 nm. The discriminate function found depends both on local blood fraction volume THB and oxygenation SO2. A pull-back approach of spectral data acquisition is disclosed which takes into account tissue motility in esophagus and measurement geometry peculiarities. The pull-back approach provides a significant improvement of measurement reproducibility and reduction of data deviation by 75-100%, resulting in a better discrimination between different histological groups.

Abstract translation: 描述了一种使用在485,513,598和629nm的四个不同波长的最小四个波长进行漫反射测量的鉴别功能来计算发育不良与巴雷特食管（无论是否具有炎性成分）之间的统计学显着性差异的方法。 发现的鉴别功能取决于局部血液成分体积THB和氧合SO2。 公开了光谱数据采集的回退方法，其考虑了食管中的组织运动和测量几何特征。 拉回方法显着提高了测量重现性，并将数据偏差减少了75-100％，从而导致不同组织学组之间的更好区分。