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公开(公告)号：US20180185341A1
公开(公告)日：2018-07-05
申请号：US15516443
申请日：2015-10-02
Applicant: Novartis AG
Inventor： Nicole BUSCHMANN , Robin Alec FAIRHURST , Pascal FURET , Diana GRAUS PORTA , Carolina HAEFLIGER , Bo HAN , Thomas KNÖPFEL , Catherine LEBLANC , Lv LIAO , Robert MAH , Masato MURAKAMI , Pierre NIMSGERN , Michael PALMER , Dale PORTER , Sebastien RIPOCHE , Can WANG , Youzhen WANG , Andreas WEISS , Jing XIONG , Xianglin ZHAO
IPC: A61K31/4375 , A61K31/496 , A61P35/00
CPC classification number: A61K31/4375 , A61K31/4545 , A61K31/496 , A61K31/55 , A61P35/00
Abstract: The present invention relates to therapeutic uses of compounds of formula (I) or a pharmaceutically acceptable salt thereof
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公开(公告)号：US20210299100A1
公开(公告)日：2021-09-30
申请号：US17201268
申请日：2021-03-15
Applicant: Novartis AG
Inventor： Vincent BORDAS , Cara BROCKLEHURST , Patrick CHENE , Zhongbo FEI , Pascal FURET , Vito GUAGNANO , Patricia IMBACH-WEESE , Joerg KALLEN , Mickael LE DOUGET , Jialiang LI , Wei LI , Edwige Liliane Jeanne LORTHIOIS , Joseph McKENNA , Bahaa SALEM , Tobias SCHMELZLE , Holger SELLNER , Nicolas SOLDERMANN , Markus VOEGTLE , Markus WARTMANN
IPC: A61K31/4155 , C07D307/81 , C07D405/12 , A61K31/343 , A61K31/443 , A61K31/426 , C07D417/04 , C07D407/04 , A61K31/357 , C07D405/04 , A61K31/403 , A61K31/4525 , A61K31/351 , C07D407/12 , A61K31/506 , A61K31/41 , A61K31/4025 , A61K31/4439 , C07D405/14 , A61P35/00
Abstract: The present invention provides a compound of formula (1) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
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公开(公告)号：US20190076412A1
公开(公告)日：2019-03-14
申请号：US16190087
申请日：2018-11-13
Applicant: NOVARTIS AG
Inventor： Nicole BUSCHMANN , Robin Alec FAIRHURST , Pascal FURET , Thomas KNÖPFEL , Catherine LEBLANC , Lv LIAO , Robert MAH , Pierre NIMSGERN , Sebastien RIPOCHE , Jing XIONG , Bo HAN , Can WANG , Xianglin ZHAO
IPC: A61K31/4375 , A61K31/4545 , A61P35/00 , A61K31/55 , A61K31/496
Abstract: The present invention relates to therapeutic uses of compounds of formula (1) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20140011798A1
公开(公告)日：2014-01-09
申请号：US13748790
申请日：2013-01-24
Applicant: NOVARTIS AG
Inventor： Pascal FURET , Vito GUAGNANO , Philipp HOLZER , Joerg KALLEN , Lv LIAO , Robert MAH , Liang MAO , Keiichi MASUYA , Achim SCHLAPBACH , Stefan STUTZ , Andrea VAUPEL
IPC: C07D487/04 , A61K31/4439 , A61K45/06 , A61K31/5377 , A61K31/501 , A61K31/541 , A61K31/4188 , A61K31/506
CPC classification number: C07D487/04 , A61K31/4188 , A61K31/4439 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06
Abstract: The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.
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公开(公告)号：US20240382600A1
公开(公告)日：2024-11-21
申请号：US18687615
申请日：2022-08-30
Applicant: Novartis AG
Inventor： Emilie CHAPEAU , Patrick CHENE , Pascal FURET , Laurence KIEFFER , Rainer MACHAUER , Anne PICARD , Tobias SCHMELZLE , Holger SELLNER , Nicolas SOLDERMANN , Markus VOEGTLE , Markus WARTMANN
IPC: A61K47/54 , A61K47/55 , C07D405/14 , C07D417/12
Abstract: The present disclosure relates to a conjugate comprising a YAP/TAZ-TEAD Protein Protein Interaction Inhibitor (PPII) linked to a Ligase Binder via a linker, or a pharmaceutically acceptable salt thereof, as well as methods of using such conjugates.
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Patent Agency Ranking
公开(公告)号：US20190231760A1
公开(公告)日：2019-08-01
申请号：US16289612
申请日：2019-02-28
Applicant: NOVARTIS AG
Inventor： Nicole BUSCHMANN , Robin Alec FAIRHURST , Pascal FURET , Diana GRAUS PORTA , Carolina HAEFLIGER , Bo HAN , Thomas KNOPFEL , Catherine LEBLANC , Lv LIAO , Robert MAH , Masato MURAKAMI , Pierre NIMSGERN , Michael PALMER , Dale PORTER , Sebastien RIPOCHE , Can WANG , Youzhen WANG , Andreas WEISS , Jing XIONG , Xianglin ZHAO
IPC: A61K31/4375 , A61P35/00 , A61K31/4545 , A61K31/496 , A61K31/55
Abstract: The present invention relates to therapeutic uses of compounds of formula (I) or a pharmaceutically acceptable salt thereof
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公开(公告)号：US20150342951A1
公开(公告)日：2015-12-03
申请号：US14365512
申请日：2012-12-14
Applicant: NOVARTIS AG
Inventor： Nigel Graham COOKE , Paulo Antonio FERNANDES GOMES DOS SANTOS , Pascal FURET , Christina HEBACH , Klemens HOGENAUER , Gregory HOLLINGWORTH , Christoph KALIS , Ian LEWIS , Alexander Baxter SMITH , Nicolas SOLDERMANN , Frederic STAUFFER , Ross STRANG , Frank STOWASSER , Nicola TUFFILLI , Anette VON MATT , Romain WOLF , Frederic ZECRI
IPC: A61K31/519 , A61K31/551 , A61K31/541 , A61K31/5377 , A61K31/517
CPC classification number: A61K31/519 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D239/74 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/14 , C07D487/08 , Y02A50/409 , Y02A50/411 , Y02A50/414
Abstract: The invention relates to new uses of PI3K inhibitors, wherein said inhibitors have an inhibitory action on the PI3K isoform delta for the treatment of immunopathology in a subject suffering from a disease or disorder selected from malaria, leishmaniasis, trypanosomiasis, toxoplasmosis and/or neurocysticercosis, via functional inhibition of TLR9 of the infected subject.
Abstract translation: 本发明涉及PI3K抑制剂的新用途，其中所述抑制剂对PI3K同种型δ具有抑制作用，用于治疗患有选自疟疾，利什曼病，锥虫病，弓形虫病和/或神经囊尾erc病的疾病或病症的受试者的免疫病理学， 通过功能抑制受感染受试者的TLR9。
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公开(公告)号：US20240382457A1
公开(公告)日：2024-11-21
申请号：US18776928
申请日：2024-07-18
Applicant: Novartis AG
Inventor： Vincent BORDAS , Cara BROCKLEHURST , Patrick CHENE , Pascal FURET , Vito GUAGNANO , Patricia IMBACH-WEESE , Joerg KALLEN , Mickael LE DOUGET , Edwige Liliane Jeanne LORTHIOIS , Joseph MCKENNA , Bahaa SALEM , Tobias SCHMELZLE , Holger SELLNER , Nicolas SOLDERMANN , Markus VOEGTLE , Markus WARTMANN
IPC: A61K31/4155 , A61K31/343 , A61K31/351 , A61K31/357 , A61K31/4025 , A61K31/403 , A61K31/41 , A61K31/426 , A61K31/443 , A61K31/4439 , A61K31/4525 , A61K31/506 , A61P35/00 , C07D307/81 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D417/04
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
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公开(公告)号：US20140343084A1
公开(公告)日：2014-11-20
申请号：US14327639
申请日：2014-07-10
Applicant: Novartis AG
Inventor： Pascal FURET , Vito GUAGNANO , Philipp HOLZER , Joerg KALLEN , Lv LIAO , Robert MAH , Liang MAO , Keiichi MASUYA , Achim SCHLAPBACH , Stefan STUTZ , Andrea VAUPEL
IPC: C07D487/04
CPC classification number: C07D487/04 , A61K31/4188 , A61K31/4439 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06
Abstract: The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.
Abstract translation: 本发明涉及式（I）化合物：如本文所述，包含这些化合物的药物制剂，用于治疗由MDM2和/或MDM4的活性介导的疾病或疾病的这些化合物的用途和方法，以及 包含这些化合物的组合。
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公开(公告)号：US20130225574A1
公开(公告)日：2013-08-29
申请号：US13773947
申请日：2013-02-22
Applicant: Novartis AG
Inventor： Giorgio CARAVATTI , Robin Alec FAIRHURST , Pascal FURET , Frederic STAUFFER , Frank Hans SEILER , Clive MCCARTHY , Heinrich RUEEGER
IPC: C07D413/14 , A61K31/5377 , A61K45/06
CPC classification number: C07D498/04 , A61K31/5377 , A61K45/06 , C07D413/14
Abstract: The present invention relates to oxazolidin-2-one substituted pyrimidine compounds that act as PI3K (phosphatidylinositol-3-kinase) inhibitors, as well as pharmaceutical compositions thereof, methods for their manufacture and uses for the treatment of conditions, diseases and disorders dependent on PI3K.
Abstract translation: 本发明涉及作为PI3K（磷脂酰肌醇-3-激酶）抑制剂的恶唑烷-2-酮取代的嘧啶化合物及其药物组合物，其制备方法和用于治疗依赖于 PI3K。
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