公开(公告)号：US20150353996A1

公开(公告)日：2015-12-10

申请号：US14708292

申请日：2015-05-10

Applicant: Nano and Advanced Materials Institute Limited

Inventor： Yeuk Lai HOO ,  Haifeng XUAN ,  Ka Lok WU ,  Xin SHI ,  Tik Ho LAU ,  Peter Wai Man LEE

IPC: C12Q1/68 ,  G01N21/41 ,  B23K26/00 ,  G02B6/02

CPC classification number: C12Q1/6816 ,  B23K26/352 ,  G01N21/41 ,  G01N21/774 ,  G01N2021/4126 ,  G01N2021/7776 ,  G02B6/02066 ,  G02B6/02095 ,  G02B6/02147 ,  G02B6/02295 ,  Y10T29/49828

Abstract: A label free, reusable and high sensitivity viral fiber sensor is provided in the present invention. The label free, high sensitivity and reusability are the advantages of this sensor. Long Period Microfiber Grating (LPMFG) is used for the sensing device. It allows optically detecting the change in refractive index at the grating surface with an extra high sensitivity. This provides an optical detection method to monitor DNA Hybridization. The single stranded DNA (ssDNA) probe is immobilized onto the LPMFG's surface for hybridizing with a DNA sample in order to identify the viral strain in the sample. This LPMFG-based viral sensor functions by inducing a refractive index change on the grating surface through the bio-molecule binding between the target viral ssDNA and the immobilized probe ssDNA. Regeneration of a surface-immobilized probe without a significant loss of hybridization activity retains at least 10 successive assays without any significant loss of performance (less than 10% decrease).

Abstract translation: 在本发明中提供了无标记，可重复使用和高灵敏度的病毒纤维传感器。 无标签，高灵敏度和可重用性是该传感器的优点。 长周期超细纤维光栅（LPMFG）用于传感器件。 它允许以极高的灵敏度光学地检测光栅表面的折射率变化。 这提供了一种监测DNA杂交的光学检测方法。 将单链DNA（ssDNA）探针固定在LPMFG表面上用于与DNA样品杂交，以鉴定样品中的病毒株。 该基于LPMFG的病毒传感器通过在目标病毒ssDNA和固定化探针ssDNA之间的生物分子结合诱导光栅表面上的折射率变化而起作用。 表面固定化探针的再生没有杂交活性的显着损失保留至少10次连续测定，而没有任何显着的性能损失（小于10％的降低）。

公开(公告)号：US20190309141A1

公开(公告)日：2019-10-10

申请号：US16368893

申请日：2019-03-29

Applicant: Nano and Advanced Materials Institute Limited

Inventor： Kai LI ,  Tik Ho LAU ,  Ho Yin FONG

IPC: C08J11/08

Abstract: The present invention relates to a method of continuously recycling thermoset plastic waste. The method includes crushing the thermoset plastic waste into pieces with a diameter size suitable for being fed into an extruder. The method also includes purifying the thermoset plastic waste by cleaning the thermoset plastic waste using a cleaning agent to remove contaminants from the thermoset plastic waste. The method also includes extruding the thermoset plastic waste by using supercritical solvent.