公开(公告)号：US20140064324A1

公开(公告)日：2014-03-06

申请号：US14073126

申请日：2013-11-06

Applicant: National Institute of Standards and Technology

Inventor： JOHN J. KASIANOWICZ ,  Joseph E. Reiner ,  Arvind K. Balijepalli ,  Joseph W. Robertson ,  Daniel L. Burden ,  Lisa Burden

IPC: G01N25/00

CPC classification number: G01N25/00 ,  G01K7/16 ,  G01K2211/00

Abstract: Systems and methods for controlling the temperature of small volumes such as yoctoliter volumes, are described. The systems include one or more plasmonic nanostructures attached at or near a nanopore. Upon excitation of the plasmonic nanostructures, such as for example by exposure to laser light, the nanoparticles are rapidly heated thereby causing a change in the ionic conductance along the nanopore. The temperature change is determined from the ionic conductance. These temperature changes can be used to control rapid thermodynamic changes in molecular analytes as they interact with the nanopore.

Abstract translation: 描述了用于控制小容积（诸如yoctoliter体积）的温度的系统和方法。 该系统包括在纳米孔附近附近的一个或多个等离子体激元纳米结构。 在激发等离子体激元纳米结构时，例如通过暴露于激光，纳米颗粒被快速加热，从而导致沿纳米孔的离子电导的变化。 温度变化由离子电导确定。 这些温度变化可用于控制分子分析物与纳米孔相互作用时的快速热力学变化。

公开(公告)号：US09500610B2

公开(公告)日：2016-11-22

申请号：US14073126

申请日：2013-11-06

Applicant: National Institute of Standards and Technology

Inventor： John J. Kasianowicz ,  Joseph E. Reiner ,  Arvind K. Balijepalli ,  Joseph W. Robertson ,  Daniel L. Burden ,  Lisa Burden

IPC: G01N25/20 ,  G01K7/00 ,  G01K1/00 ,  G01N25/00 ,  G01K7/16

CPC classification number: G01N25/00 ,  G01K7/16 ,  G01K2211/00

Abstract: Systems and methods for controlling the temperature of small volumes such as yoctoliter volumes, are described. The systems include one or more plasmonic nanostructures attached at or near a nanopore. Upon excitation of the plasmonic nanostructures, such as for example by exposure to laser light, the nanoparticles are rapidly heated thereby causing a change in the ionic conductance along the nanopore. The temperature change is determined from the ionic conductance. These temperature changes can be used to control rapid thermodynamic changes in molecular analytes as they interact with the nanopore.

Abstract translation: 描述了用于控制小容积（诸如yoctoliter体积）的温度的系统和方法。 该系统包括在纳米孔附近附近的一个或多个等离子体激元纳米结构。 在激发等离子体激元纳米结构时，例如通过暴露于激光，纳米颗粒被快速加热，从而导致沿着纳米孔的离子电导的变化。 温度变化由离子电导确定。 这些温度变化可用于控制分子分析物与纳米孔相互作用时的快速热力学变化。