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    MONITORING AND ABLATION OF AUTONOMIC NERVES
    1.
    发明申请
    MONITORING AND ABLATION OF AUTONOMIC NERVES 有权
    自动神经的监测与消除

    公开(公告)号：US20150289931A1

    公开(公告)日：2015-10-15

    申请号：US14683966

    申请日：2015-04-10

    Applicant: NeuroMedic, Inc.

    Inventor： Harry A. Puryear ,  Jin Shimada

    IPC: A61B18/14

    CPC classification number: A61B18/1492 ,  A61B5/04001 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00702 ,  A61B2018/00839

    Abstract: Systems and methods provide interface to a patient's autonomic nerves via an interior lumen wall of a blood vessel. Systems can include a probe having at least one electrode for receiving electrical signals from the interior of the lumen wall. The system can include processing components for extracting the signals from noise within the patient's body. Systems can include stimulation electrodes for providing stimulation and eliciting action potentials within the patient and destructive processes for destroying nervous function. The effect of nerve destruction on the propagation of action potentials can be effectively used as a feedback mechanism for determining the amount of nervous function destruction in the patient.

    Abstract translation: 系统和方法通过血管的内腔壁为患者的自主神经提供界面。 系统可以包括具有至少一个电极的探针，用于从腔壁的内部接收电信号。 该系统可以包括用于从患者体内的噪声中提取信号的处理组件。 系统可以包括用于在患者内提供刺激和引发动作电位的刺激电极以及破坏神经功能的破坏性过程。 神经破坏对动作电位传播的影响可以有效地用作确定患者神经功能破坏量的反馈机制。

    INTRALUMINAL MICRONEUROGRAPHY DENERVATION PROBE WITH RADIO FREQUENCY ABLATION
    2.
    发明申请
    INTRALUMINAL MICRONEUROGRAPHY DENERVATION PROBE WITH RADIO FREQUENCY ABLATION 审中-公开
    具有无线电频率消除的腹腔微波消融探针

    公开(公告)号：US20170035310A1

    公开(公告)日：2017-02-09

    申请号：US15299694

    申请日：2016-10-21

    Applicant: NeuroMedic, Inc.

    Inventor： Jin Shimada ,  Harry A. Puryear

    IPC: A61B5/04 ,  A61B18/14

    CPC classification number: A61B5/04001 ,  A61B5/201 ,  A61B5/4035 ,  A61B5/4836 ,  A61B5/6876 ,  A61B5/725 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2018/00023 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1407 ,  A61B2018/1467 ,  A61B2018/162 ,  A61B2018/1861 ,  A61B2562/0209 ,  A61B2562/028 ,  A61B2562/043

    Abstract: An intraluminal microneurography probe has a probe body configured to be introduced into an artery near an organ of a body without preventing the flow of blood through the artery. An expandable sense electrode and an expandable stimulation electrode are fixed to the probe body at one end of each electrode such that movement of the other end toward the fixed end causes the sense electrode to expand from the probe body toward a wall of the artery. A ground electrode is configured to couple to the body, and a plurality of electrical connections are operable to electrically couple the electrodes to electrical circuitry. The sense electrode is operable to measure sympathetic nerve activity in response to excitation of the stimulation electrode. A radio frequency ablation element is located between the expandable sense electrode and expandable stimulation electrode, and is operable to ablate nerves proximate to the artery.

    Abstract translation: 管腔内微量测微探针具有探针体，该探针体被配置成被引入身体器官附近的动脉，而不会阻止血液通过动脉流动。 可扩展感测电极和可膨胀的刺激电极在每个电极的一端固定到探针主体，使得另一端朝向固定端的运动导致感测电极从探针体朝向动脉的壁膨胀。 接地电极被配置为耦合到主体，并且多个电连接可操作以将电极电耦合到电路。 感测电极可操作以响应于刺激电极的激发来测量交感神经活动。 射频消融元件位于可扩展感测电极和可膨胀的刺激电极之间，并且可操作以消融靠近动脉的神经。

    INTRALUMINAL MICRONEUROGRAPHY DENERVATION PROBE WITH RADIO FREQUENCY ABLATION
    4.
    发明申请
    INTRALUMINAL MICRONEUROGRAPHY DENERVATION PROBE WITH RADIO FREQUENCY ABLATION 审中-公开

    公开(公告)号：US20200077907A1

    公开(公告)日：2020-03-12

    申请号：US16517180

    申请日：2019-07-19

    Applicant: NeuroMedic, Inc.

    Inventor： Jin Shimada ,  Harry A. Puryear

    IPC: A61B5/04 ,  A61B5/00 ,  A61B18/14 ,  A61B5/20 ,  A61B18/18

    Abstract: An intraluminal microneurography probe has a probe body configured to be introduced into an artery near an organ of a body without preventing the flow of blood through the artery. An expandable sense electrode and an expandable stimulation electrode are fixed to the probe body at one end of each electrode such that movement of the other end toward the fixed end causes the sense electrode to expand from the probe body toward a wall of the artery. A ground electrode is configured to couple to the body, and a plurality of electrical connections are operable to electrically couple the electrodes to electrical circuitry. The sense electrode is operable to measure sympathetic nerve activity in response to excitation of the stimulation electrode. A radio frequency ablation element is located between the expandable sense electrode and expandable stimulation electrode, and is operable to ablate nerves proximate to the artery.

    MONITORING NERVE ACTIVITY
    6.
    发明申请
    MONITORING NERVE ACTIVITY 审中-公开

    公开(公告)号：US20180280082A1

    公开(公告)日：2018-10-04

    申请号：US15996978

    申请日：2018-06-04

    Applicant: NeuroMedic, Inc.

    Inventor： Harry A. Puryear ,  Jin Shimada

    IPC: A61B18/14

    Abstract: Systems and methods provide interface to a patient's autonomic nerves via an interior lumen wall of a blood vessel. Systems can include a probe having at least one electrode for receiving electrical signals from the interior of the lumen wall. The system can include processing components for extracting the signals from noise within the patient's body. Systems can include stimulation electrodes for providing stimulation and eliciting action potentials within the patient and destructive processes for destroying nervous function. The effect of nerve destruction on the propagation of action potentials can be effectively used as a feedback mechanism for determining the amount of nervous function destruction in the patient.

    NERVE PROBE
    7.
    发明申请
    NERVE PROBE 审中-公开

    公开(公告)号：US20180221087A1

    公开(公告)日：2018-08-09

    申请号：US15943354

    申请日：2018-04-02

    Applicant: NeuroMedic, Inc.

    Inventor： Harry A. Puryear ,  Jin Shimada

    IPC: A61B18/14 ,  A61B18/00 ,  A61B5/04

    CPC classification number: A61B18/1492 ,  A61B5/04001 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00702 ,  A61B2018/00839

    Abstract: Systems and methods provide interface to a patient's autonomic nerves via an interior lumen wall of a blood vessel. Systems can include a probe having at least one electrode for receiving electrical signals from the interior of the lumen wall. The system can include processing components for extracting the signals from noise within the patient's body. Systems can include stimulation electrodes for providing stimulation and eliciting action potentials within the patient and destructive processes for destroying nervous function. The effect of nerve destruction on the propagation of action potentials can be effectively used as a feedback mechanism for determining the amount of nervous function destruction in the patient.

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