公开(公告)号：US11652981B2

公开(公告)日：2023-05-16

申请号：US16808300

申请日：2020-03-03

Applicant: NIKON CORPORATION

Inventor： Wan Qin ,  Brian Stamper

IPC: H04N17/00 ,  A61B3/00 ,  G06V40/18

CPC classification number: H04N17/002 ,  A61B3/0025 ,  G06V40/193

Abstract: An assessment assembly (10) for assessing a fundus imaging system (12) includes at least one, curved, flexible resolution test chart (40). Each of the resolution test charts (40) can include a chart body (342), and a plurality of spaced apart chart features (344). Moreover, each of the resolution test charts (40) can be fixedly coupled to an artificial retina region (36) of an artificial eye (14). The artificial retina region (36) can be shaped and sized similar to a retina region (19E) of a human eye (19), and the artificial retina region (36) can have scattering and depolarization properties that are similar to the scattering and depolarization properties of the retina region (19E) of the human eye (19). The fundus imaging system (12) can capture one or more images (20) of the resolution test charts (40) that are evaluated to determine a resolution of the fundus imaging system (12).

公开(公告)号：US20220347685A1

公开(公告)日：2022-11-03

申请号：US17661733

申请日：2022-05-02

Applicant: Nikon Corporation

Inventor： Wan Qin ,  Fardad Ali Hashemi

IPC: B01L3/00

Abstract: Microchannels include membranes operable with magnets or other actuators to deliver samples to one or more reaction zones defined in the microchannels. Membrane flexing can direct samples to selected reaction zones and each reaction zone can be independently temperature controlled to implement a PCR-based sample analysis.

公开(公告)号：US11248901B2

公开(公告)日：2022-02-15

申请号：US17262656

申请日：2019-07-22

Applicant: Nikon Corporation

Inventor： Eric Peter Goodwin ,  Wan Qin

IPC: G01B9/02 ,  G01B9/04 ,  G01N21/45 ,  G02B21/34 ,  G03H1/00 ,  G03H1/04

Abstract: Object interference in biological samples generated by lateral shearing interference microscopes is addressed by a shearing microscope slide comprising a periodic structure having alternating reference and sample regions. In some embodiments, the reference regions are configured to provide references that remove sample overlap in a sheared microscopic measurement. A system for generating sheared microscopic measurements is also provided that comprises an inlet configured to receive a sample material, an outlet configured to release a portion of the sample material, and a periodic structure having a plurality of interleaved reference and sample channels. In some cases, the sample channels are configured to accommodate a flow of sample material from the inlet to the outlet and the reference channels are configured to provide references that remove sample overlap in a sheared microscopic measurement.

公开(公告)号：US20210302150A1

公开(公告)日：2021-09-30

申请号：US17262656

申请日：2019-07-22

Applicant: Nikon Corporation

Inventor： Eric Peter Goodwin ,  Wan Qin

IPC: G01B9/02 ,  G01B9/04 ,  G01N21/45 ,  G02B21/34 ,  G03H1/00 ,  G03H1/04

Abstract: Object interference in biological samples generated by lateral shearing interference microscopes is addressed by a shearing microscope slide comprising a periodic structure having alternating reference and sample regions. In some embodiments, the reference regions are configured to provide references that remove sample overlap in a sheared microscopic measurement. A system for generating sheared microscopic measurements is also provided that comprises an inlet configured to receive a sample material, an outlet configured to release a portion of the sample material, and a periodic structure having a plurality of interleaved reference and sample channels. In some cases, the sample channels are configured to accommodate a flow of sample material from the inlet to the outlet and the reference channels are configured to provide references that remove sample overlap in a sheared microscopic measurement.

公开(公告)号：US20200288117A1

公开(公告)日：2020-09-10

申请号：US16808300

申请日：2020-03-03

Applicant: NIKON CORPORATION

Inventor： Wan Qin ,  Brian Stamper

IPC: H04N17/00

Abstract: An assessment assembly (10) for assessing a fundus imaging system (12) includes at least one, curved, flexible resolution test chart (40). Each of the resolution test charts (40) can include a chart body (342), and a plurality of spaced apart chart features (344). Moreover, each of the resolution test charts (40) can be fixedly coupled to an artificial retina region (36) of an artificial eye (14). The artificial retina region (36) can be shaped and sized similar to a retina region (19E) of a human eye (19), and the artificial retina region (36) can have scattering and depolarization properties that are similar to the scattering and depolarization properties of the retina region (19E) of the human eye (19). The fundus imaging system (12) can capture one or more images (20) of the resolution test charts (40) that are evaluated to determine a resolution of the fundus imaging system (12).