公开(公告)号：US11737982B2

公开(公告)日：2023-08-29

申请号：US16377032

申请日：2019-04-05

Applicant: Nitto Denko Corporation

Inventor： Roger Adami ,  Yuwei Wang ,  Haiqing Yin ,  Liping Wang ,  Dong Liu ,  Wenbin Ying

IPC: A61K9/19 ,  C12N15/11 ,  A61K47/26 ,  A61K47/36 ,  A61K47/40 ,  A61K9/127 ,  A61K9/51 ,  A61K31/713 ,  A61K9/14 ,  C12N15/113

CPC classification number: A61K9/19 ,  A61K9/1271 ,  A61K9/145 ,  A61K9/146 ,  A61K9/5123 ,  A61K31/713 ,  A61K47/26 ,  A61K47/36 ,  A61K47/40 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32

Abstract: This invention provides compositions for making a solid lyophile of one or more nucleic acid active agents, which can be reconstituted as a drug product. The composition can include an aqueous suspension of lipid nanoparticles in a pharmaceutically acceptable solution, wherein the lipid nanoparticles encapsulate one or more nucleic acid active agents, a dextrin compound, and a saccharide compound. The nucleic acid active agents can be RNAi molecules capable of mediating RNA interference, as well as other RNAs and oligonucleotides.

公开(公告)号：US20190231695A1

公开(公告)日：2019-08-01

申请号：US16377032

申请日：2019-04-05

Applicant: Nitto Denko Corporation

Inventor： Roger Adami ,  Yuwei Wang ,  Haiqing Yin ,  Liping Wang ,  Dong Liu ,  Wenbin Ying

IPC: A61K9/19 ,  A61K31/713 ,  A61K9/51 ,  A61K9/127 ,  A61K47/40 ,  A61K47/36 ,  A61K9/14 ,  C12N15/11 ,  A61K47/26 ,  C12N15/113

CPC classification number: A61K9/19 ,  A61K9/1271 ,  A61K9/145 ,  A61K9/146 ,  A61K9/5123 ,  A61K31/713 ,  A61K47/26 ,  A61K47/36 ,  A61K47/40 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32

Abstract: This invention provides compositions for making a solid lyophile of one or more nucleic acid active agents, which can be reconstituted as a drug product. The composition can include an aqueous suspension of lipid nanoparticles in a pharmaceutically acceptable solution, wherein the lipid nanoparticles encapsulate one or more nucleic acid active agents, a dextrin compound, and a saccharide compound. The nucleic acid active agents can be RNAi molecules capable of mediating RNA interference, as well as other RNAs and oligonucleotides.

公开(公告)号：US20170020819A1

公开(公告)日：2017-01-26

申请号：US15217098

申请日：2016-07-22

Applicant: Nitto Denko Corporation

Inventor： Roger Adami ,  Yuwei Wang ,  Haiqing Ying ,  Liping Wang ,  Dong Liu ,  Wenbin Ying

IPC: A61K9/19 ,  C12N15/113 ,  A61K9/14

CPC classification number: A61K9/19 ,  A61K9/145 ,  A61K9/146 ,  A61K47/26 ,  A61K47/36 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32

Abstract: This invention provides compositions for making a solid lyophile of one or more nucleic acid active agents, which can be reconstituted as a drug product. The composition can include an aqueous suspension of lipid nanoparticles in a pharmaceutically acceptable solution, wherein the lipid nanoparticles encapsulate one or more nucleic acid active agents, a dextrin compound, and a saccharide compound. The nucleic acid active agents can be RNAi molecules capable of mediating RNA interference, as well as other RNAs and oligonucleotides.

Abstract translation: 本发明提供用于制备一种或多种核酸活性剂的固体冻干物的组合物，其可以重构为药物产品。 所述组合物可以包括在药学上可接受的溶液中的脂质纳米颗粒的水性悬浮液，其中所述脂质纳米颗粒包封一种或多种核酸活性剂，糊精化合物和糖类化合物。 核酸活性剂可以是能够介导RNA干扰的RNAi分子，以及其它RNA和寡核苷酸。

公开(公告)号：US20240000710A1

公开(公告)日：2024-01-04

申请号：US18346115

申请日：2023-06-30

Applicant: Nitto Denko Corporation

Inventor： Roger Adami ,  Yuwei Wang ,  Haiqing Yin ,  Liping Wang ,  Dong Liu ,  Wenbin Ying

IPC: A61K9/19 ,  C12N15/11 ,  A61K47/26 ,  A61K47/36 ,  A61K47/40 ,  A61K9/127 ,  A61K9/51 ,  A61K31/713 ,  A61K9/14 ,  C12N15/113

CPC classification number: A61K9/19 ,  C12N15/111 ,  A61K47/26 ,  A61K47/36 ,  A61K47/40 ,  A61K9/1271 ,  A61K9/5123 ,  A61K31/713 ,  A61K9/145 ,  A61K9/146 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32

Abstract: Compositions for making a solid lyophile of one or more nucleic acid active agents, which can be reconstituted as a drug product. The composition can include an aqueous suspension of lipid nanoparticles in a pharmaceutically acceptable solution, wherein the lipid nanoparticles encapsulate one or more nucleic acid active agents, a dextrin compound, and a saccharide compound. The nucleic acid active agents can be RNAi molecules capable of mediating RNA interference, as well as other RNAs and oligonucleotides.

公开(公告)号：US10300018B2

公开(公告)日：2019-05-28

申请号：US15217098

申请日：2016-07-22

Applicant: Nitto Denko Corporation

Inventor： Roger Adami ,  Yuwei Wang ,  Haiqing Yin ,  Liping Wang ,  Dong Liu ,  Wenbin Ying

IPC: A61K9/19 ,  A61K9/14 ,  C12N15/113 ,  C12N15/11 ,  A61K47/26 ,  A61K47/36

Abstract: This invention provides compositions for making a solid lyophile of one or more nucleic acid active agents, which can be reconstituted as a drug product. The composition can include an aqueous suspension of lipid nanoparticles in a pharmaceutically acceptable solution, wherein the lipid nanoparticles encapsulate one or more nucleic acid active agents, a dextrin compound, and a saccharide compound. The nucleic acid active agents can be RNAi molecules capable of mediating RNA interference, as well as other RNAs and oligonucleotides.