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    Systems and Methods using Nucleic Acid Photoacoustic Nanosensors for Cytokine Detection
    1.
    发明申请
    Systems and Methods using Nucleic Acid Photoacoustic Nanosensors for Cytokine Detection 有权

    公开(公告)号：US20220183562A1

    公开(公告)日：2022-06-16

    申请号：US17549345

    申请日：2021-12-13

    Applicant: Northeastern University

    Inventor： Heather A. Clark ,  Kevin Bardon ,  Nicole Langlois

    IPC: A61B5/00

    Abstract: A DNA-based nanosensor system performs photoacoustic detection of cytokines. Cytokine receptors and a photoacoustic reporter dye are used in the nanosensor for cytokine detection, which can be reversible, and can be performed continuously, in vivo, in real time. Upon receptor binding to the cytokine, the DNA structure of the nanosensor closes to induce controlled dye stacking for photoacoustic application/interrogation, resulting in an increase in photoacoustic signal in the presence of the detected cytokine. The open or closed state of the sensor can be determined through differential signals as detected with photoacoustic imaging. A system using the nanosensor performs simultaneous multiplexed cytokine imaging, in the form of an inline and removable system paired with a clinical photoacoustic instrument. Cytokines can be detected in animal research use and in human point-of-care use.

    Enzymatic Nanosensor Compositions and Methods
    3.
    发明申请
    Enzymatic Nanosensor Compositions and Methods 审中-公开
    酶学纳米传感器组合物和方法

    公开(公告)号：US20150030544A1

    公开(公告)日：2015-01-29

    申请号：US14383036

    申请日：2013-03-06

    Applicant: Northeastern University

    Inventor： Heather A. Clark ,  Kevin Joseph Cash

    IPC: C12Q1/26 ,  A61K49/00 ,  G01N33/58 ,  C12Q1/32 ,  C12Q1/54

    CPC classification number: C12Q1/26 ,  A61K49/005 ,  C12Q1/32 ,  C12Q1/44 ,  C12Q1/54 ,  G01N33/543 ,  G01N33/582

    Abstract: Disclosed herein are compositions including a nanosensor that is sensitive to an analyte such that the nanosensor emits a fluorescent signal upon detecting the analyte, and a catalytic agent that catalyzes a reaction in which a target substrate is converted into one or more products, such that at least one of the one or more products is the analyte. In addition, methods of using the nanosensor-catalytic agent compositions to detect a target substrate are disclosed.

    Abstract translation: 本文公开了包括对分析物敏感的纳米传感器的组合物，使得在检测到分析物时纳米传感器发射荧光信号，以及催化剂，其催化将靶基质转化成一种或多种产物的反应，使得在 一种或多种产物中的至少一种是分析物。 此外，公开了使用纳米传感器 - 催化剂组合物来检测目标衬底的方法。

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