公开(公告)号：US20230295551A1

公开(公告)日：2023-09-21

申请号：US18021447

申请日：2021-08-17

Applicant: Northeastern University

Inventor： Linh TRUONG ,  David Medina CRUZ ,  Thomas WEBSTER

IPC: C12M1/00 ,  C12M1/12 ,  C12M1/04 ,  C12N1/20

CPC classification number: C12M29/10 ,  C12M23/04 ,  C12M23/34 ,  C12M25/02 ,  C12M23/24 ,  C12N1/20

Abstract: A continuous perfusion bioreactor for microbial synthesis of metallic nanoparticles provides synthesis of nanoparticles without washout of the microbial cells. The perfusion bioreactor includes an inlet fluidically coupled to a holding compartment with a first flow barrier, which disperses the medium into a reaction compartment suitable for culture of microbial cells which synthesize nanoparticles. A second flow barrier in the reaction compartment prevents washout of the microbial cells but enables collection of the nanoparticles suspended in depleted nutrient medium.