公开(公告)号：US11648211B2

公开(公告)日：2023-05-16

申请号：US17030286

申请日：2020-09-23

Applicant: Northeastern University

Inventor： Paige Baldwin ,  Srinivas Sridhar ,  Bijay Singh

IPC: A61K9/51 ,  A61K9/10 ,  A61K45/06 ,  B82Y5/00

CPC classification number: A61K9/5184 ,  A61K9/10 ,  A61K45/06 ,  B82Y5/00

Abstract: Pharmaceutical formulations (nanococktails) include two or more nanoparticulate delivery vehicles each including an active agent. The nanococktails can be formulated at any ratio of active agents by changing the ratio of nanoparticulate delivery vehicles in the nanococktail. The nanoparticulate delivery vehicles can have matched surface potential to prevent aggregation. The nanoparticulate delivery vehicles of the combined formulation are designed to provide each active agent with desired, preferably overlapping therapeutic windows and a specifically selected pharmacokinetic and pharmacodynamic profile when the nanococktail is administered to a subject. Each of the nanoparticulate delivery vehicles can be designed to enhance solubility, duration of action, targeting, stability, and to program release while preventing degradation of an active agent and preventing side effects, toxicity, and tolerability issues in a subject.

公开(公告)号：US09921226B2

公开(公告)日：2018-03-20

申请号：US14778779

申请日：2014-04-08

Applicant: Northeastern University

Inventor： Samira Faegh ,  Nader Jalili ,  Srinivas Sridhar

IPC: G01N29/036 ,  G01N29/02 ,  G01G3/16 ,  G01N33/66 ,  G01N33/543

CPC classification number: G01N33/66 ,  G01G3/16 ,  G01N29/022 ,  G01N29/036 ,  G01N33/5438 ,  G01N2291/0257

Abstract: An interchangeable sensor system is described, including: a microcantilever including a beam anchored at a first end, the beam being free to vibrate on another end, wherein a piezoelectric layer is deposited on a surface of the beam; an input configured to receive a voltage from a voltage source for applying voltage to the piezoelectric layer; and a resonating circuit including: the piezoelectric layer, configured as a capacitor of the resonant circuit; and one or more additional electrical elements; wherein the voltage source is configured to apply a first AC voltage under a first condition for actuating the microcantilever at a first mechanical resonating frequency of the microcantilever and a second AC voltage under a second condition for actuating the microcantilever at a second electrical resonating frequency of the resonating circuit. Method of using the sensor system is also described.

公开(公告)号：US11701046B2

公开(公告)日：2023-07-18

申请号：US16347049

申请日：2017-11-02

Applicant: Northeastern University

Inventor： Srinivas Sridhar ,  Craig Versek ,  Peter Bex

IPC: A61B5/291 ,  A61B5/378 ,  A61B3/10 ,  A61B5/00 ,  A61B5/16

CPC classification number: A61B5/291 ,  A61B5/378 ,  A61B5/4082 ,  A61B5/4088 ,  A61B5/6803 ,  A61B3/10 ,  A61B5/162 ,  A61B5/6831 ,  A61B5/7264 ,  A61B5/742 ,  A61B2562/0209 ,  A61B2562/14

Abstract: A portable wireless neuromonitoring device can be used to diagnose and/or treat conditions of the brain and vision system. The device includes a sensor unit mountable on the head of a human subject and capable of recording signals from the brain in EEG and/or EFEG (electric field encephalography) mode, and the device can be used for simultaneous stimulus display and recording with latency of less than 1 millisecond. The device also includes electrodes that allow rapid set-up and measurement with low impedance contact with the scalp. The device can also be used in conjunction with virtual reality or alternate reality environments.

公开(公告)号：US20180271978A1

公开(公告)日：2018-09-27

申请号：US15752099

申请日：2016-08-15

Applicant: Northeastern University ,  Dana-Farber Cancer Institute, Inc. ,  The Brigham and Women's Hospital, Inc.

Inventor： Wilfred Ngwa ,  Rajiv Kumar ,  Gerassimos Makrigiorgos ,  Srinivas Sridhar ,  Stephanie Dougan

IPC: A61K41/00 ,  C07K16/28 ,  A61K47/69 ,  A61N5/10

CPC classification number: A61K41/0038 ,  A61K39/00 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/0428 ,  A61N5/062 ,  A61N5/1007 ,  A61N7/00 ,  A61N2005/1019 ,  A61N2005/1089 ,  A61N2005/1098 ,  C07K16/2878

Abstract: Compositions and methods for the radiological and immunotherapeutic treatment of cancer are provided. Metallic nanoparticles conjugated with an immunoadjuvant are dispersed within a biodegradable polymer matrix that can be implanted in a patient and released gradually. The implant may be configured as, or be a component of, brachytherapy spacers and applicators, or radiotherapy fiducial markers. The composition may be combined with marginless radiotherapy, allowing for lower doses of radiation and enhancing the immune response against cancer, including at non-irradiated sites.

公开(公告)号：US12121339B2

公开(公告)日：2024-10-22

申请号：US15747202

申请日：2016-06-09

Applicant: Northeastern University

Inventor： Codi Gharagouzloo ,  Srinivas Sridhar

IPC: A61B5/055 ,  A61B5/00 ,  G01R33/48 ,  G01R33/56 ,  G01R33/563

CPC classification number: A61B5/055 ,  A61B5/4064 ,  G01R33/4816 ,  G01R33/5601 ,  G01R33/5635 ,  G01R33/56366 ,  A61B5/4088 ,  A61B5/4244 ,  A61B5/425 ,  A61B5/4866 ,  A61B2576/026

Abstract: A quantitative, ultrashort time to echo, contrast-enhanced magnetic resonance imaging technique is provided. The technique can be used to accurately measure contrast agent concentration in the blood, to provide clear, high-definition angiograms, and to measure absolute quantities of cerebral blood volume on a voxel-by-voxel basis.

公开(公告)号：US10912480B2

公开(公告)日：2021-02-09

申请号：US14896511

申请日：2014-06-20

Applicant: Northeastern University

Inventor： Srinivas Sridhar ,  Yury Petrov ,  Ozgur Yavuzcetin ,  Kaushik Chowdhury

IPC: A61B5/0478 ,  A61B5/00 ,  A61B5/04 ,  A61B5/11

Abstract: A sensor system and process for measuring electromagnetic activity of a brain are provided. The system and process employ a sensor assembly having a plurality of electrodes arranged in a closely spaced arrangement and a processor to determine a weighted average of the signals indicative of an electric field generated by electromagnetic activity of the brain. The system provides a medical body area network of a subject including one or more of the sensor assemblies and one or more additional sensors, which may be within a smartphone or other wearable device.

公开(公告)号：US10799604B2

公开(公告)日：2020-10-13

申请号：US15328711

申请日：2015-07-27

Applicant: Northeastern University ,  The Brigham and Women's Hospital, Inc. ,  Dana-Farber Cancer Institute, Inc.

Inventor： Rajiv Kumar ,  Srinivas Sridhar ,  Wilfred Ngwa ,  Robert Cormack ,  Gerassimos Makrigiorgos

IPC: A61K49/00 ,  A61L31/14 ,  A61K49/04 ,  A61K45/06 ,  A61L31/04 ,  A61P35/04 ,  A61K9/00 ,  A61K9/20 ,  A61B90/00 ,  A61B5/00 ,  A61K31/337 ,  A61L31/06 ,  A61L31/16 ,  A61L31/18 ,  A61N5/10

Abstract: A method of detecting migration of tumor cells is provided by implanting in a region of tumor cells one or more implants having a matrix material of a biocompatible and biodegradable polymer, and a plurality of nanoparticles dispersed within the matrix material and functionalized to bind tumor cells. Nanoparticles bound to the tumor cells that have migrated out of the region can be detected by various imaging modalities. The implant can be in the shape of a brachytherapy spacer or radiotherapy fiducial maker or can be a coating on a brachytherapy spacer or fiducial marker. A method of treating cancer is provided by implanting one or more brachytherapy spacers or fiducial markers including the matrix material and an anti-cancer therapeutic agent dispersed within the matrix material.

公开(公告)号：US10111871B2

公开(公告)日：2018-10-30

申请号：US14914932

申请日：2014-08-27

Applicant: Northeastern University

Inventor： Shifalika Tangutoori ,  Srinivas Sridhar

IPC: A61K9/127 ,  A61K31/502 ,  A61K45/06 ,  A61K31/4188 ,  A61K31/5025 ,  A61K31/704 ,  A61K31/7068 ,  A61K33/24

Abstract: The invention provides pharmaceutical formulations of inhibitors for poly (ADP-ribose) polymerase (PARP) enzyme. The formulations can be used in the treatment and prevention of cancer as well as the treatment of neurotrauma and neurodegenerative diseases. The PARP inhibitor is delivered in the form of nanoparticles that provide efficient delivery of the inhibitor into cancer cells or other cells and release of the inhibitor within the cells. In treating cancer, the result is killing of tumor cells, whereas in treatment of neurotrauma and neurodegenerative disease, the result is preservation of cell function.