公开(公告)号：US20180105619A1

公开(公告)日：2018-04-19

申请号：US15730780

申请日：2017-10-12

Applicant: Novartis AG

Inventor： Frank Chang ,  Troy Vernon Holland ,  Thomas M. Moy

IPC: C08F28/02 ,  C08F22/38 ,  C08F20/56

CPC classification number: C08F28/02 ,  C08F2/38 ,  C08F8/34 ,  C08F20/56 ,  C08F22/38 ,  C08F220/56 ,  C08F230/02 ,  C08F2810/20 ,  G02B1/04 ,  C08L43/02

Abstract: The invention is related to a class of hydrophilic polymers each comprising one sole thiol-containing terminal group. The hydrophilic polymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses.

公开(公告)号：US10287370B2

公开(公告)日：2019-05-14

申请号：US15730780

申请日：2017-10-12

Applicant: Novartis AG

Inventor： Frank Chang ,  Troy Vernon Holland ,  Thomas M. Moy

IPC: C08F28/02 ,  C08F20/56 ,  C08F22/38 ,  C08F2/38 ,  C08F220/56 ,  C08F230/02 ,  C08F8/34 ,  G02B1/04

Abstract: The invention is related to a class of hydrophilic polymers each comprising one sole thiol-containing terminal group. The hydrophilic polymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses.

公开(公告)号：US10962803B2

公开(公告)日：2021-03-30

申请号：US16260544

申请日：2019-01-29

Applicant: Novartis AG

Inventor： Steve Yun Zhang ,  Daqing Wu ,  Richard Charles Breitkopf ,  Weihong Lang ,  Junhao Ge ,  Maria F. Gubitosi Raspino ,  Frank Chang ,  Thomas M. Moy ,  Troy Vernon Holland

IPC: G02B1/04 ,  G02C7/04 ,  C09D143/00 ,  C08F230/00 ,  C08J7/04

Abstract: The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating of a hydrophilic copolymer thereon and to a method for producing the same. The hydrogel lens body comprises or is made of a polymeric material having 1,2- and/or 1,3-diol moieties, and the hydrophilic copolymer comprises arylborono-containing repeating units each having a boronic acid group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one boronic acid group and one 1,2-diol or 1,3-diol group. The soft contact lens has a surface lubricity higher than the surface lubricity of the lens body.

公开(公告)号：US20190235277A1

公开(公告)日：2019-08-01

申请号：US16260544

申请日：2019-01-29

Applicant: Novartis AG

Inventor： Steve Yun Zhang ,  Daqing Wu ,  Richard Charles Breitkopf ,  Weihong Lang ,  Junhao Ge ,  Maria F. Gubitosi Raspino ,  Frank Chang ,  Thomas M. Moy ,  Troy Vernon Holland

IPC: G02C7/04 ,  C09D143/00 ,  C08J7/04 ,  C08F230/00

CPC classification number: G02C7/049 ,  C08F230/00 ,  C08J7/047 ,  C08J2329/14 ,  C08J2443/00 ,  C09D143/00 ,  G02B1/043

Abstract: The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating of a hydrophilic copolymer thereon and to a method for producing the same. The hydrogel lens body comprises or is made of a polymeric material having 1,2- and/or 1,3-diol moieties, and the hydrophilic copolymer comprises arylborono-containing repeating units each having a boronic acid group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one boronic acid group and one 1,2-diol or 1,3-diol group. The soft contact lens has a surface lubricity higher than the surface lubricity of the lens body.