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    SERINE PROTEASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
    4.
    发明公开
    SERINE PROTEASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME 审中-公开

    公开(公告)号：US20230193327A1

    公开(公告)日：2023-06-22

    申请号：US16318509

    申请日：2017-07-14

    Applicant: NOVOZYMES A/S

    Inventor： Dorte M.K. Klitgaard ,  Roland Alexander Pache ,  Martin Gudman ,  Anders G. Sandström

    IPC: C12P7/10 ,  C12N9/58

    CPC classification number: C12P7/10 ,  C12N9/58 ,  C12Y304/21

    Abstract: The present invention relates to serine protease variants, having improved properties compared to the parent protease, in particular variants of a serine protease derived from a strain of Meripilus giganteus belonging to the S53 family. The varinats according to the invention have in particular increased stability, e.g., increased thermo-stability, increased specific activity, and/or increased expression levels, compared to the parent protease. The present invention also relates to polynucleotides encoding the variants; nucleic N acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

    Serine protease variants and polynucleotides encoding same
    8.
    发明授权
    Serine protease variants and polynucleotides encoding same 有权

    公开(公告)号：US11447763B2

    公开(公告)日：2022-09-20

    申请号：US17148790

    申请日：2021-01-14

    Applicant: NOVOZYMES A/S

    Inventor： Keiichi Ayabe ,  Tomoko Matsui ,  Aki Tomiki ,  Yuma Kurakata ,  Esben P. Friis ,  Jens E. Nielsen ,  Roland Alexander Pache

    IPC: C12N9/58 ,  C12P7/06

    Abstract: The present invention relates to protease variants, having improved properties compared to the parent protease, in particular variants of a serine protease belonging to family 53 derived from a strain of Meripilus giganteus. The variants according to the invention have in particular increased thermo-stability, e.g., increased residual activity after 30 min at a temperature in the range from 55 to 60° C. and/or increased thermal denaturation temperature, compared to the parent Meripilus giganteus protease. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

    SERINE PROTEASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
    9.
    发明申请
    SERINE PROTEASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME 有权

    公开(公告)号：US20210139876A1

    公开(公告)日：2021-05-13

    申请号：US17148790

    申请日：2021-01-14

    Applicant: NOVOZYMES A/S

    Inventor： Keiichi Ayabe ,  Tomoko Matsui ,  Aki Tomiki ,  Yuma Kurakata ,  Esben P. Friis ,  Jens E. Nielsen ,  Roland Alexander Pache

    IPC: C12N9/58 ,  C12P7/06

    Abstract: The present invention relates to protease variants, having improved properties compared to the parent protease, in particular variants of a serine protease belonging to family 53 derived from a strain of Meripilus giganteus. The variants according to the invention have in particular increased thermo-stability, e.g., increased residual activity after 30 min at a temperature in the range from 55 to 60° C. and/or increased thermal denaturation temperature, compared to the parent Meripilus giganteus protease. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

    SERINE PROTEASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
    10.
    发明申请
    SERINE PROTEASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME 审中-公开

    公开(公告)号：US20190352629A1

    公开(公告)日：2019-11-21

    申请号：US16318496

    申请日：2017-07-14

    Applicant: NOVOZYMES A/S

    Inventor： Keiichi Ayabe ,  Tomoko Matsui ,  Aki Tomiki ,  Yuma Kurakata ,  Esben Peter Friis ,  Jens Erik Nielsen ,  Roland Alexander Pache

    IPC: C12N9/58 ,  C12P7/06

    Abstract: The present invention relates to protease variants, having improved properties compared to the parent protease, in particular variants of a serine protease belonging to family 53 derived from a strain of Meripilus giganteus. The variants according to the invention have in particular increased thermo-stability, e.g., increased residual activity after 30 min at a temperature in the range from 55 to 60° C. and/or increased thermal denaturation temperature, compared to the parent Meripilus giganteus protease. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

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