公开(公告)号：US20240041758A1

公开(公告)日：2024-02-08

申请号：US18227463

申请日：2023-07-28

Applicant: Ocular Therapeutix, Inc.

Inventor： Charles D. Blizzard ,  Rami El-Hayek ,  Michael Goldstein ,  Peter Jarrett ,  Andrew Vanslette

IPC: A61K9/00 ,  A61K38/13 ,  A61K47/10 ,  A61K47/22 ,  A61P27/02

CPC classification number: A61K9/0051 ,  A61K38/13 ,  A61K47/10 ,  A61K47/22 ,  A61P27/02

Abstract: Provided herein are sustained release biodegradable intracanalicular insert comprising a hydrogel and cyclosporine, methods of treating or preventing an ocular disease in a subject in need thereof by administering such inserts as well as methods of manufacturing such inserts.

公开(公告)号：US11779536B2

公开(公告)日：2023-10-10

申请号：US17681238

申请日：2022-02-25

Applicant: Ocular Therapeutix, Inc.

Inventor： Charles D. Blizzard ,  Rami El-Hayek ,  Michael Goldstein ,  Peter Jarrett ,  Andrew Vanslette

IPC: A61K9/00 ,  A61K38/13 ,  A61K47/10 ,  A61K47/22 ,  A61P27/02

CPC classification number: A61K9/0051 ,  A61K38/13 ,  A61K47/10 ,  A61K47/22 ,  A61P27/02

Abstract: Provided herein are sustained release biodegradable intracanalicular insert comprising a hydrogel and cyclosporine, methods of treating or preventing an ocular disease in a subject in need thereof by administering such inserts as well as methods of manufacturing such inserts.

公开(公告)号：US20210308043A1

公开(公告)日：2021-10-07

申请号：US17210696

申请日：2021-03-24

Applicant: Ocular Therapeutix, Inc.

Inventor： Charles D. Blizzard ,  Arthur Driscoll ,  Rami El-Hayek ,  Michael Goldstein ,  Joseph Iacona ,  Peter Jarrett ,  Timothy S. Jarrett ,  Erica Kahn ,  Zachary Lattrell

IPC: A61K9/00 ,  A61K9/06 ,  A61K31/4439 ,  A61K47/34

Abstract: The invention relates to a sustained release biodegradable ocular implant containing a tyrosine kinase inhibitor dispersed in a hydrogel for the treatment of a retinal disease for an extended period of time.

公开(公告)号：US20250120906A1

公开(公告)日：2025-04-17

申请号：US18928908

申请日：2024-10-28

Applicant: OCULAR THERAPEUTIX, INC.

Inventor： Charles D. Blizzard ,  Rami El-Hayek ,  Michael Goldstein ,  Peter Jarrett ,  Andrew Vanslette

IPC: A61K9/00 ,  A61K9/06 ,  A61K38/13 ,  A61K49/00 ,  A61P27/02

Abstract: Provided herein are sustained release biodegradable intracanalicular inserts comprising a hydrogel and an active agent, methods of treating or preventing an ocular disease in a subject in need thereof by administering such inserts as well as methods of manufacturing such inserts.

公开(公告)号：US12023276B2

公开(公告)日：2024-07-02

申请号：US18278538

申请日：2022-02-23

Applicant: OCULAR THERAPEUTIX, INC.

Inventor： Peter Jarrett ,  Erik Wong

IPC: A61F9/007 ,  A61F9/00

CPC classification number: A61F9/0017

Abstract: Disclosed in certain embodiments is an intracanalicular injectable applicator device includes a body forming a cavity and a cannula coupled to a first distal end of the body. The cannula forms a channel that is aligned with the cavity of the body. The cannula is configured to store an intracanalicular injectable in the channel. The intracanalicular injectable applicator device further includes a tip structure coupled to the body. The tip structure is disposed around at least a portion of the cannula. A distal end of the tip structure is configured to dilate a lacrimal punctum by inserting the distal end of the tip structure into the canaliculus via the lacrimal punctum. The intracanalicular injectable applicator device further includes an actuating structure configured to push the intracanalicular injectable through the channel and the distal end of the tip structure into a canaliculus via a lacrimal punctum.

公开(公告)号：US11439592B2

公开(公告)日：2022-09-13

申请号：US17210696

申请日：2021-03-24

Applicant: Ocular Therapeutix, Inc.

Inventor： Charles D. Blizzard ,  Arthur Driscoll ,  Rami El-Hayek ,  Michael Goldstein ,  Joseph Iacona ,  Peter Jarrett ,  Timothy S. Jarrett ,  Erica Kahn ,  Zachary Lattrell

IPC: A61K9/00 ,  A61K9/06 ,  A61K31/4439 ,  A61K47/34 ,  A61P27/02 ,  A61K31/4427 ,  A61K45/06

Abstract: The invention relates to a sustained release biodegradable ocular implant containing a tyrosine kinase inhibitor dispersed in a hydrogel for the treatment of a retinal disease for an extended period of time.

公开(公告)号：US11291627B1

公开(公告)日：2022-04-05

申请号：US17483250

申请日：2021-09-23

Applicant: Ocular Therapeutix, Inc.

Inventor： Charles D. Blizzard ,  Rami El-Hayek ,  Michael Goldstein ,  Peter Jarrett ,  Andrew Vanslette

IPC: A61K38/13 ,  A61K9/00 ,  A61P27/02

Abstract: Provided herein are sustained release biodegradable intracanalicular insert comprising a hydrogel and cyclosporine, methods of treating or preventing an ocular disease in a subject in need thereof by administering such inserts as well as methods of manufacturing such inserts.

公开(公告)号：US12226341B2

公开(公告)日：2025-02-18

申请号：US18282124

申请日：2022-03-24

Applicant: OCULAR THERAPEUTIX, INC.

Inventor： Peter Jarrett ,  Erik Wong ,  Eric Dickinson

IPC: A61F9/00 ,  A61M5/158

Abstract: A system (100) includes a first assembly (110A) and a second assembly (110B). The first assembly (110A) includes a body (120) forming a first interior volume, a plunger (130) comprising a first distal end disposed within the first interior volume, a wire comprising a first distal end secured to the first distal end of the plunger (130), and a plunger clip (140) configured to interface with the plunger (130) and the body (120) to prevent actuation of the plunger (130). The second assembly (110B) includes a cowl (150) forming a second interior volume, a needle comprising a hub and a shaft, and a cowl cap disposed partially within the hub to secure the implant in the shaft. A first distal end of the shaft is connected to the hub. The hub is disposed within the second interior volume. The shaft is configured to receive an implant.

公开(公告)号：US12161753B2

公开(公告)日：2024-12-10

申请号：US18020544

申请日：2021-09-23

Applicant: OCULAR THERAPEUTIX, INC.

Inventor： Charles D. Blizzard ,  Rami El-Hayek ,  Michael Goldstein ,  Peter Jarrett ,  Andrew Vanslette

IPC: A61K9/00 ,  A61K9/06 ,  A61K38/13 ,  A61K49/00 ,  A61P27/02

Abstract: Provided herein are sustained release biodegradable intracanalicular inserts comprising a hydrogel and an active agent, methods of treating or preventing an ocular disease in a subject in need thereof by administering such inserts as well as methods of manufacturing such inserts.

公开(公告)号：US12109302B2

公开(公告)日：2024-10-08

申请号：US18227463

申请日：2023-07-28

Applicant: Ocular Therapeutix, Inc.

Inventor： Charles D. Blizzard ,  Rami El-Hayek ,  Michael Goldstein ,  Peter Jarrett ,  Andrew Vanslette

IPC: A61K9/00 ,  A61K38/13 ,  A61K47/10 ,  A61K47/22 ,  A61P27/02

CPC classification number: A61K9/0051 ,  A61K38/13 ,  A61K47/10 ,  A61K47/22 ,  A61P27/02

Abstract: Provided herein are sustained release biodegradable intracanalicular insert comprising a hydrogel and cyclosporine, methods of treating or preventing an ocular disease in a subject in need thereof by administering such inserts as well as methods of manufacturing such inserts.