公开(公告)号：US20190185575A1

公开(公告)日：2019-06-20

申请号：US16328259

申请日：2017-08-25

Applicant: ONCOTHERAPY SCIENCE, INC.

Inventor： Yosuke HARADA ,  Suyoun CHUNG ,  Yusuke NAKAMURA

IPC: C07K16/30 ,  C12N15/85 ,  G01N33/573 ,  G01N33/574

CPC classification number: C07K16/30 ,  C07K16/18 ,  C12N15/85 ,  C12N2015/8518 ,  G01N33/573 ,  G01N33/57492 ,  G01N2800/364 ,  G01N2800/50 ,  G01N2800/52

Abstract: The present invention relates to monoclonal antibodies against MELK. Furthermore, the present invention provides methods for diagnosing MELK-associated diseases using the antibodies, methods for detecting the MELK protein, methods for determining the drug efficacy following treatment with a MELK inhibitor, methods of screening for subjects to whom a MELK inhibitor has a high therapeutic effect, and diagnostic reagents containing the antibodies.